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GPR173 G protein-coupled receptor 173 [ Homo sapiens (human) ]

Gene ID: 54328, updated on 25-Nov-2021

Summary

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Official Symbol
GPR173provided by HGNC
Official Full Name
G protein-coupled receptor 173provided by HGNC
Primary source
HGNC:HGNC:18186
See related
Ensembl:ENSG00000184194 MIM:300253
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SREB3
Summary
This gene encodes a member of the G-protein coupled receptor 1 family. This protein contains 7 transmembrane domains and conserved cysteine residues. [provided by RefSeq, Nov 2009]
Expression
Broad expression in brain (RPKM 6.2), ovary (RPKM 2.6) and 14 other tissues See more
Orthologs
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Genomic context

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See GPR173 in Genome Data Viewer
Location:
Xp11.22
Exon count:
3
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (53048789..53080615)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (53077971..53109797)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 156 member B Neighboring gene family with sequence similarity 156 member A Neighboring gene TSPY like 2 Neighboring gene KANTR integral membrane protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. GPR173 agonist phoenixin 20 promotes osteoblastic differentiation of MC3T3-E1 cells. Gu Z, et al. Aging (Albany NY), 2020 Nov 10. PMID 33196456, Free PMC Article
  2. Meta-analysis of GWAS on both Chinese and European populations identifies GPR173 as a novel X chromosome susceptibility gene for SLE. Zhang H, et al. Arthritis Res Ther, 2018 May 3. PMID 29724251, Free PMC Article
  3. Identification and molecular docking studies for novel inverse agonists of SREB, super conserved receptor expressed in brain. Yanai T, et al. Genes Cells, 2016 Jul. PMID 27184081
  4. An evolutionarily conserved G-protein coupled receptor family, SREB, expressed in the central nervous system. Matsumoto M, et al. Biochem Biophys Res Commun, 2000 Jun 7. PMID 10833454
  5. A systematic, large-scale resequencing screen of X-chromosome coding exons in mental retardation. Tarpey PS, et al. Nat Genet, 2009 May. PMID 19377476, Free PMC Article

See all (13) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. GPR173 agonist phoenixin 20 promotes osteoblastic differentiation of MC3T3-E1 cells.
    Title: GPR173 agonist phoenixin 20 promotes osteoblastic differentiation of MC3T3-E1 cells.
  2. Single-nucleotide polymorphism rs13440883 in GPR173 was found to be significantly associated with systemic lupus erythematous
    Title: Meta-analysis of GWAS on both Chinese and European populations identifies GPR173 as a novel X chromosome susceptibility gene for SLE.
  3. a molecular model of GPR173 was constructed using the screening results. The combination of computational and biological methods will provide a unique approach to ligand identification for orphan GPCRs and brain research.
    Title: Identification and molecular docking studies for novel inverse agonists of SREB, super conserved receptor expressed in brain.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables gonadotropin-releasing hormone receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to gonadotropin-releasing hormone IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of neuron migration IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 

General protein information

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Preferred Names
probable G-protein coupled receptor 173
Names
super conserved receptor expressed in brain 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_015966.1 RefSeqGene

    Range
    5001..36292
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_018969.6 → NP_061842.1  probable G-protein coupled receptor 173

    See identical proteins and their annotated locations for NP_061842.1

    Status: REVIEWED

    Source sequence(s)
    BX322635
    Consensus CDS
    CCDS14349.1
    UniProtKB/Swiss-Prot
    Q9NS66
    Related
    ENSP00000331600.5, ENST00000332582.5
    Conserved Domains (1) summary
    cd15217
    Location:23 → 351
    7tmA_SREB3_GPR173; super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    53048789..53080615
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011530798.2 → XP_011529100.1  probable G-protein coupled receptor 173 isoform X1

    See identical proteins and their annotated locations for XP_011529100.1

    UniProtKB/Swiss-Prot
    Q9NS66
    Conserved Domains (1) summary
    cd15217
    Location:23 → 351
    7tmA_SREB3_GPR173; super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of seven-transmembrane G protein-coupled receptors
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NS66.1 GenPept UniProtKB/Swiss-Prot:Q9NS66

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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