Format

Send to:

Choose Destination

GPR173 G protein-coupled receptor 173 [ Homo sapiens (human) ]

Gene ID: 54328, updated on 12-Oct-2019

Summary

Official Symbol
GPR173provided by HGNC
Official Full Name
G protein-coupled receptor 173provided by HGNC
Primary source
HGNC:HGNC:18186
See related
Ensembl:ENSG00000184194 MIM:300253
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SREB3
Summary
This gene encodes a member of the G-protein coupled receptor 1 family. This protein contains 7 transmembrane domains and conserved cysteine residues. [provided by RefSeq, Nov 2009]
Expression
Broad expression in brain (RPKM 6.2), ovary (RPKM 2.6) and 14 other tissues See more
Orthologs

Genomic context

See GPR173 in Genome Data Viewer
Location:
Xp11.22
Exon count:
3
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (53049324..53080615)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (53078506..53109797)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 156 member B Neighboring gene family with sequence similarity 156 member A Neighboring gene TSPY like 2 Neighboring gene KDM5C adjacent transcript Neighboring gene RNA, U7 small nuclear 37 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

  • GPCRs, Class A Rhodopsin-like, organism-specific biosystem (from WikiPathways)
    GPCRs, Class A Rhodopsin-like, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.gpcr.org/7tm/ (originally at http://www.cmbi.kun.nl/7tm/). The groupings are based on the GPCR phylogenetic tree available fr...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor activity TAS
Traceable Author Statement
more info
PubMed 
gonadotropin-releasing hormone receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
cellular response to gonadotropin-releasing hormone IEA
Inferred from Electronic Annotation
more info
 
negative regulation of neuron migration IEA
Inferred from Electronic Annotation
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
probable G-protein coupled receptor 173
Names
super conserved receptor expressed in brain 3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_015966.1 RefSeqGene

    Range
    5001..36292
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_018969.5NP_061842.1  probable G-protein coupled receptor 173

    See identical proteins and their annotated locations for NP_061842.1

    Status: REVIEWED

    Source sequence(s)
    BC009861, BX322635, CA445634
    Consensus CDS
    CCDS14349.1
    UniProtKB/Swiss-Prot
    Q9NS66
    Related
    ENSP00000331600.4, ENST00000332582.4
    Conserved Domains (1) summary
    cd15217
    Location:23351
    7tmA_SREB3_GPR173; super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    53049324..53080615
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011530798.2XP_011529100.1  probable G-protein coupled receptor 173 isoform X1

    See identical proteins and their annotated locations for XP_011529100.1

    UniProtKB/Swiss-Prot
    Q9NS66
    Conserved Domains (1) summary
    cd15217
    Location:23351
    7tmA_SREB3_GPR173; super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of seven-transmembrane G protein-coupled receptors
Support Center