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GPR173 G protein-coupled receptor 173 [ Homo sapiens (human) ]

Gene ID: 54328, updated on 5-Jul-2025
Official Symbol
GPR173provided by HGNC
Official Full Name
G protein-coupled receptor 173provided by HGNC
Primary source
HGNC:HGNC:18186
See related
Ensembl:ENSG00000184194 MIM:300253; AllianceGenome:HGNC:18186
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SREB3
Summary
This gene encodes a member of the G-protein coupled receptor 1 family. This protein contains 7 transmembrane domains and conserved cysteine residues. [provided by RefSeq, Nov 2009]
Expression
Broad expression in brain (RPKM 6.2), ovary (RPKM 2.6) and 14 other tissues See more
Orthologs
mouse all
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See GPR173 in Genome Data Viewer
Location:
Xp11.22
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (53048789..53080615)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (52333387..52366851)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (53077971..53109797)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124905190 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29648 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29649 Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:52963212-52964184 Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:52964185-52965156 Neighboring gene family with sequence similarity 156 member A Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:53018839-53019418 Neighboring gene ReSE screen-validated silencer GRCh37_chrX:53045322-53045423 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:53100667-53101168 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29651 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20852 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20853 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20854 Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:53122416-53123240 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29653 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20855 Neighboring gene TSPY like 2 Neighboring gene KANTR integral membrane protein Neighboring gene RNA, U7 small nuclear 37 pseudogene

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. GPR173 agonist phoenixin 20 promotes osteoblastic differentiation of MC3T3-E1 cells. Gu Z, et al. Aging (Albany NY), 2020 Nov 10. PMID 33196456, Free PMC Article
  2. Meta-analysis of GWAS on both Chinese and European populations identifies GPR173 as a novel X chromosome susceptibility gene for SLE. Zhang H, et al. Arthritis Res Ther, 2018 May 3. PMID 29724251, Free PMC Article
  3. Identification and molecular docking studies for novel inverse agonists of SREB, super conserved receptor expressed in brain. Yanai T, et al. Genes Cells, 2016 Jul. PMID 27184081
  4. An evolutionarily conserved G-protein coupled receptor family, SREB, expressed in the central nervous system. Matsumoto M, et al. Biochem Biophys Res Commun, 2000 Jun 7. PMID 10833454
  5. A systematic, large-scale resequencing screen of X-chromosome coding exons in mental retardation. Tarpey PS, et al. Nat Genet, 2009 May. PMID 19377476, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. GPR173 agonist phoenixin 20 promotes osteoblastic differentiation of MC3T3-E1 cells.
    Title: GPR173 agonist phoenixin 20 promotes osteoblastic differentiation of MC3T3-E1 cells.
  2. Single-nucleotide polymorphism rs13440883 in GPR173 was found to be significantly associated with systemic lupus erythematous
    Title: Meta-analysis of GWAS on both Chinese and European populations identifies GPR173 as a novel X chromosome susceptibility gene for SLE.
  3. a molecular model of GPR173 was constructed using the screening results. The combination of computational and biological methods will provide a unique approach to ligand identification for orphan GPCRs and brain research.
    Title: Identification and molecular docking studies for novel inverse agonists of SREB, super conserved receptor expressed in brain.
Submit: New GeneRIF Correction

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables G protein-coupled receptor activity TAS
Traceable Author Statement
more info
 PubMed 
enables gonadotropin-releasing hormone receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables gonadotropin-releasing hormone receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to gonadotropin-releasing hormone IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of neuron migration IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
probable G-protein coupled receptor 173
Names
super conserved receptor expressed in brain 3

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_015966.1 RefSeqGene

    Range
    4466..36292
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_018969.6 → NP_061842.1  probable G-protein coupled receptor 173

    See identical proteins and their annotated locations for NP_061842.1

    Status: REVIEWED

    Source sequence(s)
    BX322635
    Consensus CDS
    CCDS14349.1
    UniProtKB/Swiss-Prot
    B1B0A5, Q9NS66
    Related
    ENSP00000331600.5, ENST00000332582.5
    Conserved Domains (1) summary
    cd15217
    Location:23 → 351
    7tmA_SREB3_GPR173; super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    53048789..53080615
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047442184.1 → XP_047298140.1  probable G-protein coupled receptor 173 isoform X1

    UniProtKB/Swiss-Prot
    B1B0A5, Q9NS66

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    52333387..52366851
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054327255.1 → XP_054183230.1  probable G-protein coupled receptor 173 isoform X1

    UniProtKB/Swiss-Prot
    B1B0A5, Q9NS66
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NS66.1 GenPept UniProtKB/Swiss-Prot:Q9NS66

Gene LinkOut

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