GPR173 G protein-coupled receptor 173 [Homo sapiens (human)] - Gene

Summary

Official Symbol: GPR173provided by HGNC
Official Full Name: G protein-coupled receptor 173provided by HGNC
Primary source: HGNC:HGNC:18186
See related: Ensembl:ENSG00000184194 MIM:300253; AllianceGenome:HGNC:18186
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: SREB3
Summary: This gene encodes a member of the G-protein coupled receptor 1 family. This protein contains 7 transmembrane domains and conserved cysteine residues. [provided by RefSeq, Nov 2009]
Expression: Broad expression in brain (RPKM 6.2), ovary (RPKM 2.6) and 14 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: Xp11.22

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2023_03	current	GRCh38.p14 (GCF_000001405.40)	X	NC_000023.11 (53048789..53080615)
RS_2023_03	current	T2T-CHM13v2.0 (GCF_009914755.1)	X	NC_060947.1 (52333387..52366851)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	X	NC_000023.10 (53077971..53109797)

Chromosome X - NC_000023.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GPR173 agonist phoenixin 20 promotes osteoblastic differentiation of MC3T3-E1 cells.
Title: GPR173 agonist phoenixin 20 promotes osteoblastic differentiation of MC3T3-E1 cells.
Single-nucleotide polymorphism rs13440883 in GPR173 was found to be significantly associated with systemic lupus erythematous
Title: Meta-analysis of GWAS on both Chinese and European populations identifies GPR173 as a novel X chromosome susceptibility gene for SLE.
a molecular model of GPR173 was constructed using the screening results. The combination of computational and biological methods will provide a unique approach to ligand identification for orphan GPCRs and brain research.
Title: Identification and molecular docking studies for novel inverse agonists of SREB, super conserved receptor expressed in brain.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

DXS1008E (e-PCR)
- UniSTS:99636

DXS7563 (e-PCR)
- UniSTS:153986

RH99258 (e-PCR)
- UniSTS:86666

DXS8062 (e-PCR)
- UniSTS:20153

SE20-4_1202 (e-PCR)
- UniSTS:277692

GPR173_9777 (e-PCR)
- UniSTS:468446

STS-N33443 (e-PCR)
- UniSTS:30686

Homology

Homologs of the GPR173 gene: The GPR173 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 230 organisms have orthologs with human gene GPR173
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	TAS Traceable Author Statement more info	PubMed
enables gonadotropin-releasing hormone receptor activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cellular response to gonadotropin-releasing hormone	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of neuron migration	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info	PubMed

General protein information

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Preferred Names: probable G-protein coupled receptor 173

Names: super conserved receptor expressed in brain 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_015966.1 RefSeqGene

Range

4466..36292

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_018969.6 → NP_061842.1 probable G-protein coupled receptor 173

See identical proteins and their annotated locations for NP_061842.1

Status: REVIEWED

Source sequence(s)

BX322635

Consensus CDS

CCDS14349.1

UniProtKB/Swiss-Prot

B1B0A5, Q9NS66

Related

ENSP00000331600.5, ENST00000332582.5

Conserved Domains (1) summary

cd15217
Location:23 → 351

7tmA_SREB3_GPR173; super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of seven-transmembrane G protein-coupled receptors