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Elovl2 elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 2 [ Mus musculus (house mouse) ]

Gene ID: 54326, updated on 26-Sep-2022

Summary

Official Symbol
Elovl2provided by MGI
Official Full Name
elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 2provided by MGI
Primary source
MGI:MGI:1858960
See related
Ensembl:ENSMUSG00000021364 AllianceGenome:MGI:1858960
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ssc2
Summary
Enables fatty acid elongase activity. Involved in fatty acid elongation, polyunsaturated fatty acid and very long-chain fatty acid biosynthetic process. Acts upstream of or within very long-chain fatty acid metabolic process. Predicted to be located in endoplasmic reticulum. Predicted to be integral component of endoplasmic reticulum membrane. Is expressed in several structures, including brain; liver; paravertebral ganglion; sensory organ; and urinary system. Orthologous to human ELOVL2 (ELOVL fatty acid elongase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver E18 (RPKM 67.6), liver adult (RPKM 66.2) and 12 other tissues See more
Orthologs
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Genomic context

See Elovl2 in Genome Data Viewer
Location:
13; 13 A3.3
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (41335858..41373879, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (41182382..41220403, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene glial cells missing homolog 2 Neighboring gene synaptonemal complex protein 2-like Neighboring gene ribosomal protein S17, pseudogene 1 Neighboring gene predicted gene, 32063

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables acyltransferase activity, transferring groups other than amino-acyl groups IDA
Inferred from Direct Assay
more info
PubMed 
enables fatty acid elongase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables fatty acid elongase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables fatty acid elongase activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables very-long-chain 3-ketoacyl-CoA synthase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in fatty acid elongation, monounsaturated fatty acid IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in fatty acid elongation, polyunsaturated fatty acid IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in fatty acid elongation, polyunsaturated fatty acid IDA
Inferred from Direct Assay
more info
PubMed 
involved_in fatty acid elongation, polyunsaturated fatty acid IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in fatty acid elongation, polyunsaturated fatty acid ISO
Inferred from Sequence Orthology
more info
 
involved_in fatty acid elongation, saturated fatty acid IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in sphingolipid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in very long-chain fatty acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in very long-chain fatty acid biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in very long-chain fatty acid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in very long-chain fatty acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within very long-chain fatty acid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
elongation of very long chain fatty acids protein 2
Names
3-keto acyl-CoA synthase Elovl2
ELOVL FA elongase 2
ELOVL family member 2
ELOVL fatty acid elongase 2
sequence similarity to Cig30 2
very long chain 3-ketoacyl-CoA synthase 2
very long chain 3-oxoacyl-CoA synthase 2
NP_001298050.1
NP_062296.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001311121.1NP_001298050.1  elongation of very long chain fatty acids protein 2 isoform 2

    See identical proteins and their annotated locations for NP_001298050.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate 5' exon and includes an alternate 5' terminal exon compared to variant 1. These differences result in a distinct 5' UTR and cause translation initiation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC158538, AK014803
    Consensus CDS
    CCDS79180.1
    UniProtKB/Swiss-Prot
    Q9JLJ4
    UniProtKB/TrEMBL
    A0A0R4J1P7, A0A6P5QPC6
    Related
    ENSMUSP00000114112.2, ENSMUST00000117096.2
    Conserved Domains (1) summary
    pfam01151
    Location:13247
    ELO; GNS1/SUR4 family
  2. NM_019423.2NP_062296.1  elongation of very long chain fatty acids protein 2 isoform 1

    See identical proteins and their annotated locations for NP_062296.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    BB277808, BB279541, BC098215, BY126714
    Consensus CDS
    CCDS36639.1
    UniProtKB/Swiss-Prot
    Q9D5Z2, Q9JLJ4
    UniProtKB/TrEMBL
    A0A6P5QW61, Q543J1
    Related
    ENSMUSP00000021793.8, ENSMUST00000021793.15
    Conserved Domains (1) summary
    pfam01151
    Location:30264
    ELO; GNS1/SUR4 family

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    41335858..41373879 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)