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Sstr2 somatostatin receptor 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 54305, updated on 2-Aug-2021

Summary

Official Symbol
Sstr2provided by RGD
Official Full Name
somatostatin receptor 2provided by RGD
Primary source
RGD:3763
See related
Ensembl:ENSRNOG00000002793
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Smstr2
Summary
binds somatostatin; mediates signaling in response to thermal pain; may play a role in regulation of intestinal peristalsis [RGD, Feb 2006]
Expression
Biased expression in Adrenal (RPKM 48.4), Brain (RPKM 31.2) and 3 other tissues See more
Orthologs
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Genomic context

See Sstr2 in Genome Data Viewer
Location:
10q32.1
Exon count:
2
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (98664204..98671370)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (102136283..102143449)

Chromosome 10 - NC_051345.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 39, member 11 Neighboring gene uncharacterized LOC120095210 Neighboring gene transfer RNA alanine (anticodon UGC) Neighboring gene family with sequence similarity 104, member A Neighboring gene component of oligomeric golgi complex 1 Neighboring gene hypothetical LOC287798

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables PDZ domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables PDZ domain binding ISO
Inferred from Sequence Orthology
more info
 
enables neuropeptide binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables peptide binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables somatostatin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables somatostatin receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables somatostatin receptor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to estradiol stimulus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular response to estradiol stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to glucocorticoid stimulus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular response to glucocorticoid stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cerebellum development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in forebrain development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in neuropeptide signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within neuropeptide signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in peristalsis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of muscle contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to starvation IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in somatostatin signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in spermatogenesis IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
somatostatin receptor type 2
Names
SRIF-1
SS-2-R
SS2-R
SS2R
somatostatin receptor subtype 2
somatotropin release-inhibiting factor receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019348.2NP_062221.1  somatostatin receptor type 2

    See identical proteins and their annotated locations for NP_062221.1

    Status: PROVISIONAL

    Source sequence(s)
    JACYVU010000220
    UniProtKB/Swiss-Prot
    P30680
    Related
    ENSRNOP00000003735.2, ENSRNOT00000003735.3
    Conserved Domains (2) summary
    pfam00001
    Location:60312
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:54327
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051345.1 Reference mRatBN7.2 Primary Assembly

    Range
    98664204..98671370
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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