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Furin furin (paired basic amino acid cleaving enzyme) [ Rattus norvegicus (Norway rat) ]

Gene ID: 54281, updated on 18-Nov-2018

Summary

Official Symbol
Furinprovided by RGD
Official Full Name
furin (paired basic amino acid cleaving enzyme)provided by RGD
Primary source
RGD:3274
See related
Ensembl:ENSRNOG00000011352
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Pace; Pcsk3
Summary
may be one of several enzymes involved in the proteolytic processing of extracellular superoxide dismutase (EC-SOD) [RGD, Feb 2006]
Expression
Biased expression in Kidney (RPKM 322.8), Liver (RPKM 310.4) and 9 other tissues See more
Orthologs

Genomic context

See Furin in Genome Data Viewer
Location:
1q31
Exon count:
17
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (142185092..142198167, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 1 NC_005100.3 (143137721..143153628, complement)

Chromosome 1 - NC_005100.4Genomic Context describing neighboring genes Neighboring gene mannosidase, alpha, class 2A, member 2 Neighboring gene uncharacterized LOC102553801 Neighboring gene FES proto-oncogene, tyrosine kinase Neighboring gene uncharacterized LOC102553864 Neighboring gene uncharacterized LOC108349447 Neighboring gene BLM RecQ like helicase

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
nerve growth factor binding IEA
Inferred from Electronic Annotation
more info
 
nerve growth factor binding ISO
Inferred from Sequence Orthology
more info
 
peptidase activity ISO
Inferred from Sequence Orthology
more info
 
peptide binding IEA
Inferred from Electronic Annotation
more info
 
peptide binding ISO
Inferred from Sequence Orthology
more info
 
protease binding IEA
Inferred from Electronic Annotation
more info
 
protease binding ISO
Inferred from Sequence Orthology
more info
 
serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
serine-type endopeptidase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
serine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
serine-type endopeptidase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
serine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
serine-type endopeptidase inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
aging IEP
Inferred from Expression Pattern
more info
PubMed 
cell proliferation IEA
Inferred from Electronic Annotation
more info
 
cell proliferation ISO
Inferred from Sequence Orthology
more info
 
dibasic protein processing IEA
Inferred from Electronic Annotation
more info
 
dibasic protein processing ISO
Inferred from Sequence Orthology
more info
 
negative regulation of endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
negative regulation of low-density lipoprotein particle receptor catabolic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of low-density lipoprotein particle receptor catabolic process ISO
Inferred from Sequence Orthology
more info
 
NOT negative regulation of nerve growth factor production ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transforming growth factor beta1 production IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transforming growth factor beta1 production ISO
Inferred from Sequence Orthology
more info
 
nerve growth factor production IEA
Inferred from Electronic Annotation
more info
 
nerve growth factor production ISO
Inferred from Sequence Orthology
more info
 
peptide biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
peptide biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
peptide hormone processing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptide hormone processing IEA
Inferred from Electronic Annotation
more info
 
peptide hormone processing ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transforming growth factor beta receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transforming growth factor beta1 activation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transforming growth factor beta1 activation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transforming growth factor beta1 activation ISS
Inferred from Sequence or Structural Similarity
more info
 
protein processing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein processing IDA
Inferred from Direct Assay
more info
PubMed 
protein processing IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein processing ISO
Inferred from Sequence Orthology
more info
 
regulation of endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
regulation of low-density lipoprotein particle receptor biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
regulation of low-density lipoprotein particle receptor biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
regulation of protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
 
regulation of signal transduction ISO
Inferred from Sequence Orthology
more info
 
secretion by cell IEA
Inferred from Electronic Annotation
more info
 
secretion by cell ISO
Inferred from Sequence Orthology
more info
 
signal peptide processing IEA
Inferred from Electronic Annotation
more info
 
signal peptide processing ISO
Inferred from Sequence Orthology
more info
 
viral life cycle IEA
Inferred from Electronic Annotation
more info
 
viral life cycle ISO
Inferred from Sequence Orthology
more info
 
zymogen activation IEA
Inferred from Electronic Annotation
more info
 
zymogen activation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
Golgi cisterna IDA
Inferred from Direct Assay
more info
PubMed 
Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
Golgi membrane ISO
Inferred from Sequence Orthology
more info
 
cell surface IEA
Inferred from Electronic Annotation
more info
 
cell surface ISO
Inferred from Sequence Orthology
more info
 
endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
endosome membrane IEA
Inferred from Electronic Annotation
more info
 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
NOT extracellular space ISO
Inferred from Sequence Orthology
more info
 
integral component of Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
membrane raft IEA
Inferred from Electronic Annotation
more info
 
membrane raft ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
trans-Golgi network IEA
Inferred from Electronic Annotation
more info
 
trans-Golgi network ISO
Inferred from Sequence Orthology
more info
 
trans-Golgi network transport vesicle IEA
Inferred from Electronic Annotation
more info
 
trans-Golgi network transport vesicle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
furin
Names
Paired basic amino acid cleaving enzyme (furin)
Proprotein convertase subtilisin/kexin type 3 (paired basic amino acid cleaving enzyme, furin, membrane associated receptor protein)
dibasic-processing enzyme
paired basic amino acid residue-cleaving enzyme
prohormone convertase 3
proprotein convertase subtilisin/kexin type3
NP_062204.1
XP_008757777.1
XP_008757778.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019331.1NP_062204.1  furin precursor

    See identical proteins and their annotated locations for NP_062204.1

    Status: PROVISIONAL

    Source sequence(s)
    X55660
    UniProtKB/Swiss-Prot
    P23377
    Related
    ENSRNOP00000015521.1, ENSRNOT00000015521.2
    Conserved Domains (5) summary
    cd04059
    Location:113402
    Peptidases_S8_Protein_convertases_Kexins_Furin-like; Peptidase S8 family domain in Protein convertases
    smart00261
    Location:638675
    FU; Furin-like repeats
    pfam00082
    Location:144427
    Peptidase_S8; Subtilase family
    pfam01483
    Location:484570
    P_proprotein; Proprotein convertase P-domain
    pfam16470
    Location:33107
    S8_pro-domain; Peptidase S8 pro-domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005100.4 Reference Rnor_6.0 Primary Assembly

    Range
    142185092..142198167 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008759555.2XP_008757777.1  furin isoform X1

    See identical proteins and their annotated locations for XP_008757777.1

    UniProtKB/TrEMBL
    G3V7I9
    Conserved Domains (5) summary
    cd04059
    Location:113402
    Peptidases_S8_Protein_convertases_Kexins_Furin-like; Peptidase S8 family domain in Protein convertases
    smart00261
    Location:638675
    FU; Furin-like repeats
    pfam00082
    Location:144427
    Peptidase_S8; Subtilase family
    pfam01483
    Location:484570
    P_proprotein; Proprotein convertase P-domain
    pfam16470
    Location:33107
    S8_pro-domain; Peptidase S8 pro-domain
  2. XM_008759556.1XP_008757778.1  furin isoform X1

    See identical proteins and their annotated locations for XP_008757778.1

    UniProtKB/TrEMBL
    G3V7I9
    Conserved Domains (5) summary
    cd04059
    Location:113402
    Peptidases_S8_Protein_convertases_Kexins_Furin-like; Peptidase S8 family domain in Protein convertases
    smart00261
    Location:638675
    FU; Furin-like repeats
    pfam00082
    Location:144427
    Peptidase_S8; Subtilase family
    pfam01483
    Location:484570
    P_proprotein; Proprotein convertase P-domain
    pfam16470
    Location:33107
    S8_pro-domain; Peptidase S8 pro-domain

Alternate Rn_Celera

Genomic

  1. AC_000069.1 Alternate Rn_Celera

    Range
    126407744..126419832 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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