U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Furin furin (paired basic amino acid cleaving enzyme) [ Rattus norvegicus (Norway rat) ]

Gene ID: 54281, updated on 10-Oct-2024

Summary

Official Symbol
Furinprovided by RGD
Official Full Name
furin (paired basic amino acid cleaving enzyme)provided by RGD
Primary source
RGD:3274
See related
EnsemblRapid:ENSRNOG00000011352 AllianceGenome:RGD:3274
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Pace; Pcsk3
Summary
Enables serine-type endopeptidase activity. Involved in several processes, including positive regulation of cell migration; positive regulation of transforming growth factor beta receptor signaling pathway; and protein processing. Located in Golgi cisterna; endoplasmic reticulum membrane; and plasma membrane. Orthologous to human FURIN (furin, paired basic amino acid cleaving enzyme). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 322.8), Liver (RPKM 310.4) and 9 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Furin in Genome Data Viewer
Location:
1q31
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (143757389..143770430, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (134348142..134361182, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (142185092..142198167, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L35A like 7 Neighboring gene mannosidase, alpha, class 2A, member 2 Neighboring gene uncharacterized LOC102553801 Neighboring gene FES proto-oncogene, tyrosine kinase Neighboring gene uncharacterized LOC134483745 Neighboring gene uncharacterized LOC108349447 Neighboring gene BLM RecQ like helicase

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables heparan sulfate binding IEA
Inferred from Electronic Annotation
more info
 
enables heparan sulfate binding ISO
Inferred from Sequence Orthology
more info
 
enables heparan sulfate binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables heparin binding IEA
Inferred from Electronic Annotation
more info
 
enables heparin binding ISO
Inferred from Sequence Orthology
more info
 
enables heparin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nerve growth factor binding IEA
Inferred from Electronic Annotation
more info
 
enables nerve growth factor binding ISO
Inferred from Sequence Orthology
more info
 
enables peptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables peptide binding IEA
Inferred from Electronic Annotation
more info
 
enables peptide binding ISO
Inferred from Sequence Orthology
more info
 
enables protease binding IEA
Inferred from Electronic Annotation
more info
 
enables protease binding ISO
Inferred from Sequence Orthology
more info
 
enables serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables serine-type endopeptidase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables serine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables serine-type endopeptidase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables serine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
enables serine-type endopeptidase inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
enables serine-type peptidase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in blastocyst formation IEA
Inferred from Electronic Annotation
more info
 
involved_in blastocyst formation ISO
Inferred from Sequence Orthology
more info
 
involved_in cytokine precursor processing IEA
Inferred from Electronic Annotation
more info
 
involved_in cytokine precursor processing ISO
Inferred from Sequence Orthology
more info
 
involved_in cytokine precursor processing ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in dibasic protein processing IEA
Inferred from Electronic Annotation
more info
 
involved_in dibasic protein processing ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of low-density lipoprotein particle receptor catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of low-density lipoprotein particle receptor catabolic process ISO
Inferred from Sequence Orthology
more info
 
NOT involved_in negative regulation of nerve growth factor production ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transforming growth factor beta1 production IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of transforming growth factor beta1 production ISO
Inferred from Sequence Orthology
more info
 
involved_in nerve growth factor production IEA
Inferred from Electronic Annotation
more info
 
involved_in nerve growth factor production ISO
Inferred from Sequence Orthology
more info
 
involved_in peptide biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in peptide biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in peptide hormone processing IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in peptide hormone processing IEA
Inferred from Electronic Annotation
more info
 
involved_in peptide hormone processing ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transforming growth factor beta receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of viral entry into host cell IEA
Inferred from Electronic Annotation
more info
 
involved_in protein maturation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein processing IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein processing IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within protein processing ISO
Inferred from Sequence Orthology
more info
 
involved_in protein processing ISO
Inferred from Sequence Orthology
more info
 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cholesterol transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of cholesterol transport ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in secretion by cell IEA
Inferred from Electronic Annotation
more info
 
involved_in secretion by cell ISO
Inferred from Sequence Orthology
more info
 
involved_in signal peptide processing IEA
Inferred from Electronic Annotation
more info
 
involved_in signal peptide processing ISO
Inferred from Sequence Orthology
more info
 
involved_in viral life cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in viral life cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in zymogen activation IEA
Inferred from Electronic Annotation
more info
 
involved_in zymogen activation ISO
Inferred from Sequence Orthology
more info
 
involved_in zymogen inhibition ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
located_in Golgi cisterna IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
located_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface IEA
Inferred from Electronic Annotation
more info
 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in endosome membrane IEA
Inferred from Electronic Annotation
more info
 
NOT located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in membrane raft IEA
Inferred from Electronic Annotation
more info
 
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in trans-Golgi network IEA
Inferred from Electronic Annotation
more info
 
located_in trans-Golgi network ISO
Inferred from Sequence Orthology
more info
 
located_in trans-Golgi network transport vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in trans-Golgi network transport vesicle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
furin
Names
Paired basic amino acid cleaving enzyme (furin)
Proprotein convertase subtilisin/kexin type 3 (paired basic amino acid cleaving enzyme, furin, membrane associated receptor protein)
dibasic-processing enzyme
paired basic amino acid residue-cleaving enzyme
prohormone convertase 3
proprotein convertase subtilisin/kexin type3
NP_062204.2
XP_008757777.1
XP_063128016.1
XP_063128021.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019331.2NP_062204.2  furin precursor

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/Swiss-Prot
    P23377
    UniProtKB/TrEMBL
    A6JCC0, G3V7I9
    Related
    ENSRNOP00000015521.1, ENSRNOT00000015521.4
    Conserved Domains (4) summary
    cd04059
    Location:113402
    Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
    smart00261
    Location:638675
    FU; Furin-like repeats
    pfam01483
    Location:484570
    P_proprotein; Proprotein convertase P-domain
    pfam16470
    Location:33107
    S8_pro-domain; Peptidase S8 pro-domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    143757389..143770430 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008759555.4XP_008757777.1  furin isoform X1

    See identical proteins and their annotated locations for XP_008757777.1

    UniProtKB/Swiss-Prot
    P23377
    UniProtKB/TrEMBL
    A6JCC0, G3V7I9
    Related
    ENSRNOP00000088247.1, ENSRNOT00000116325.2
    Conserved Domains (4) summary
    cd04059
    Location:113402
    Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
    smart00261
    Location:638675
    FU; Furin-like repeats
    pfam01483
    Location:484570
    P_proprotein; Proprotein convertase P-domain
    pfam16470
    Location:33107
    S8_pro-domain; Peptidase S8 pro-domain
  2. XM_063271951.1XP_063128021.1  furin isoform X1

    UniProtKB/TrEMBL
    A6JCC0, G3V7I9
  3. XM_063271946.1XP_063128016.1  furin isoform X1

    UniProtKB/TrEMBL
    A6JCC0, G3V7I9