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Mapk4 mitogen-activated protein kinase 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 54268, updated on 12-Aug-2018

Summary

Official Symbol
Mapk4provided by RGD
Official Full Name
mitogen-activated protein kinase 4provided by RGD
Primary source
RGD:3047
See related
Ensembl:ENSRNOG00000015401
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
mitogen activated protein kinase found in brain; may be involved in manic-depressive illness [RGD, Feb 2006]
Expression
Biased expression in Kidney (RPKM 101.7), Brain (RPKM 100.5) and 1 other tissue See more
Orthologs

Genomic context

See Mapk4 in Genome Data Viewer
Location:
18q12.2
Exon count:
7
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (69894692..70043634, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 18 NC_005117.3 (69038436..69087394, complement)

Chromosome 18 - NC_005117.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102551811 Neighboring gene maestro Neighboring gene uncharacterized LOC102551934 Neighboring gene uncharacterized LOC108348860

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
MAP kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
MAP kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
 
protein kinase binding IEA
Inferred from Electronic Annotation
more info
 
protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
protein kinase binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
MAPK cascade IEA
Inferred from Electronic Annotation
more info
 
cellular response to organic substance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
mitogen-activated protein kinase 4
Names
ERK-4
MAP kinase 4
MAP kinase isoform p63
MAPK 4
MNK2
extracellular signal-regulated kinase 4
p63-MAPK
NP_062192.1
XP_008770388.1
XP_008770389.1
XP_017456503.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019319.1NP_062192.1  mitogen-activated protein kinase 4

    See identical proteins and their annotated locations for NP_062192.1

    Status: VALIDATED

    Source sequence(s)
    AABR07032520
    UniProtKB/TrEMBL
    G3V9J9
    Related
    ENSRNOP00000050164.3, ENSRNOT00000047271.5
    Conserved Domains (2) summary
    cd07854
    Location:14351
    STKc_MAPK4_6; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinases 4 (also called ERK4) and 6 (also called ERK3)
    pfam00069
    Location:20312
    Pkinase; Protein kinase domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005117.4 Reference Rnor_6.0 Primary Assembly

    Range
    69894692..70043634 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008772167.2XP_008770389.1  mitogen-activated protein kinase 4 isoform X1

    See identical proteins and their annotated locations for XP_008770389.1

    UniProtKB/TrEMBL
    G3V9J9
    Conserved Domains (2) summary
    cd07854
    Location:14351
    STKc_MAPK4_6; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinases 4 (also called ERK4) and 6 (also called ERK3)
    pfam00069
    Location:20312
    Pkinase; Protein kinase domain
  2. XM_008772166.2XP_008770388.1  mitogen-activated protein kinase 4 isoform X1

    See identical proteins and their annotated locations for XP_008770388.1

    UniProtKB/TrEMBL
    G3V9J9
    Conserved Domains (2) summary
    cd07854
    Location:14351
    STKc_MAPK4_6; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinases 4 (also called ERK4) and 6 (also called ERK3)
    pfam00069
    Location:20312
    Pkinase; Protein kinase domain
  3. XM_017601014.1XP_017456503.1  mitogen-activated protein kinase 4 isoform X1

    UniProtKB/TrEMBL
    G3V9J9
    Conserved Domains (2) summary
    cd07854
    Location:14351
    STKc_MAPK4_6; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinases 4 (also called ERK4) and 6 (also called ERK3)
    pfam00069
    Location:20312
    Pkinase; Protein kinase domain

Alternate Rn_Celera

Genomic

  1. AC_000086.1 Alternate Rn_Celera

    Range
    65696152..65744928 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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