Format

Send to:

Choose Destination

Maf MAF bZIP transcription factor [ Rattus norvegicus (Norway rat) ]

Gene ID: 54267, updated on 25-Nov-2021

Summary

Symbol
Mafprovided by RGD
Full Name
MAF bZIP transcription factorprovided by RGD
Primary source
RGD:3034
See related
EnsemblRapid:ENSRNOG00000012428
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Maf2; cMaf
Summary
transcription factor containing a bZip DNA binding domain; may play a role in morphogenic processes and cellular differentiation [RGD, Feb 2006]
Expression
Biased expression in Kidney (RPKM 250.2), Muscle (RPKM 110.1) and 8 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Maf in Genome Data Viewer
Location:
19q12
Exon count:
5
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (43353867..43713162, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (48179826..48200995, complement)

Chromosome 19 - NC_051354.1Genomic Context describing neighboring genes Neighboring gene WW domain-containing oxidoreductase Neighboring gene uncharacterized LOC120098538 Neighboring gene uncharacterized LOC108348984 Neighboring gene uncharacterized LOC102547452 Neighboring gene uncharacterized LOC108348942

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription activator activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables double-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding IDA
Inferred from Direct Assay
more info
PubMed 
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables sequence-specific double-stranded DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in cell development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell development ISO
Inferred from Sequence Orthology
more info
 
involved_in inner ear development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within inner ear development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lens development in camera-type eye ISO
Inferred from Sequence Orthology
more info
 
involved_in lens fiber cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in lens fiber cell differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within lens fiber cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of chondrocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of chondrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
transcription factor Maf
Names
C-Maf
bZip transcription factor c-maf
proto-oncogene c-maf
transcription factor Maf-2
v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019318.2NP_062191.2  transcription factor Maf

    Status: PROVISIONAL

    Source sequence(s)
    JACYVU010000313
    Conserved Domains (2) summary
    cd14718
    Location:279347
    bZIP_Maf_large; Basic leucine zipper (bZIP) domain of large musculoaponeurotic fibrosarcoma (Maf) proteins: a DNA-binding and dimerization domain
    pfam08383
    Location:86119
    Maf_N; Maf N-terminal region

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051354.1 Reference mRatBN7.2 Primary Assembly

    Range
    43353867..43713162 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039097958.1XP_038953886.1  transcription factor Maf isoform X2

    Related
    ENSRNOP00000016577.4, ENSRNOT00000016577.6
    Conserved Domains (2) summary
    cd14718
    Location:279347
    bZIP_Maf_large; Basic leucine zipper (bZIP) domain of large musculoaponeurotic fibrosarcoma (Maf) proteins: a DNA-binding and dimerization domain
    pfam08383
    Location:86119
    Maf_N; Maf N-terminal region
  2. XM_039097956.1XP_038953884.1  transcription factor Maf isoform X1

    Conserved Domains (2) summary
    cd14718
    Location:279347
    bZIP_Maf_large; Basic leucine zipper (bZIP) domain of large musculoaponeurotic fibrosarcoma (Maf) proteins: a DNA-binding and dimerization domain
    pfam08383
    Location:86119
    Maf_N; Maf N-terminal region
  3. XM_039097957.1XP_038953885.1  transcription factor Maf isoform X2

    Conserved Domains (2) summary
    cd14718
    Location:279347
    bZIP_Maf_large; Basic leucine zipper (bZIP) domain of large musculoaponeurotic fibrosarcoma (Maf) proteins: a DNA-binding and dimerization domain
    pfam08383
    Location:86119
    Maf_N; Maf N-terminal region
  4. XM_006255696.4XP_006255758.1  transcription factor Maf isoform X3

    Related
    ENSRNOP00000097791.1, ENSRNOT00000095407.1
    Conserved Domains (2) summary
    cd14718
    Location:279347
    bZIP_Maf_large; Basic leucine zipper (bZIP) domain of large musculoaponeurotic fibrosarcoma (Maf) proteins: a DNA-binding and dimerization domain
    pfam08383
    Location:86119
    Maf_N; Maf N-terminal region
Support Center