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Gata4 GATA binding protein 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 54254, updated on 8-Jul-2018
Official Symbol
Gata4provided by RGD
Official Full Name
GATA binding protein 4provided by RGD
Primary source
RGD:2665
See related
Ensembl:ENSRNOG00000010708
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
plays a role in regulation of cardiac-myocyte specific gene expression; interacts with dHAND (HAND2) to activate transcription of several cardiac-specific genes [RGD, Feb 2006]
Expression
Biased expression in Heart (RPKM 136.0), Testes (RPKM 66.9) and 1 other tissue See more
Orthologs
See Gata4 in Genome Data Viewer
Location:
15p12
Exon count:
9
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (46386703..46458679, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 15 NC_005114.3 (50151497..50197708, complement)

Chromosome 15 - NC_005114.4Genomic Context describing neighboring genes Neighboring gene farnesyl diphosphate farnesyl transferase 1 Neighboring gene nei-like DNA glycosylase 2 Neighboring gene uncharacterized LOC102548615 Neighboring gene BLK proto-oncogene, Src family tyrosine kinase Neighboring gene family with sequence similarity 167, member A

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Adipogenesis, organism-specific biosystem (from WikiPathways)
    Adipogenesis, organism-specific biosystemThe different classess of factors involved in adipogenesis are shown. Adipogenesis is the process by which fat cells differentiate from predadipocytes to adipocytes (fat cells). Adipose tissue, compo...
  • Factors involved in megakaryocyte development and platelet production, organism-specific biosystem (from REACTOME)
    Factors involved in megakaryocyte development and platelet production, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Hemostasis, organism-specific biosystem (from REACTOME)
    Hemostasis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Thyroid hormone signaling pathway, organism-specific biosystem (from KEGG)
    Thyroid hormone signaling pathway, organism-specific biosystemThe thyroid hormones (THs) are important regulators of growth, development and metabolism. The action of TH is mainly mediated by T3 (3,5,3'-triiodo-L-thyronine). Thyroid hormones, L-thyroxine (T4) a...
  • Tight junction, organism-specific biosystem (from KEGG)
    Tight junction, organism-specific biosystemTight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of...
  • Tight junction, conserved biosystem (from KEGG)
    Tight junction, conserved biosystemTight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of...
  • cGMP-PKG signaling pathway, organism-specific biosystem (from KEGG)
    cGMP-PKG signaling pathway, organism-specific biosystemCyclic GMP (cGMP) is the intracellular second messenger that mediates the action of nitric oxide (NO) and natriuretic peptides (NPs), regulating a broad array of physiologic processes. The elevated i...
  • cGMP-PKG signaling pathway, conserved biosystem (from KEGG)
    cGMP-PKG signaling pathway, conserved biosystemCyclic GMP (cGMP) is the intracellular second messenger that mediates the action of nitric oxide (NO) and natriuretic peptides (NPs), regulating a broad array of physiologic processes. The elevated i...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
DNA binding ISO
Inferred from Sequence Orthology
more info
 
DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
contributes_to DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
NFAT protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
RNA polymerase II proximal promoter sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA polymerase II proximal promoter sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
RNA polymerase II regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
RNA polymerase II transcription factor activity, sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase II transcription factor activity, sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
activating transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
chromatin binding ISO
Inferred from Sequence Orthology
more info
 
co-SMAD binding IEA
Inferred from Electronic Annotation
more info
 
co-SMAD binding ISO
Inferred from Sequence Orthology
more info
 
enhancer sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
sequence-specific DNA binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
transcription coactivator activity IEA
Inferred from Electronic Annotation
more info
 
transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
 
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding ISO
Inferred from Sequence Orthology
more info
 
transcription factor activity, RNA polymerase II transcription factor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription factor activity, RNA polymerase II transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
transcription factor binding IDA
Inferred from Direct Assay
more info
PubMed 
transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
transcription regulatory region DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
transcription regulatory region DNA binding ISO
Inferred from Sequence Orthology
more info
 
transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
zinc ion binding TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
 
SMAD protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
Sertoli cell differentiation ISO
Inferred from Sequence Orthology
more info
 
anatomical structure formation involved in morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
animal organ morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
atrial septum morphogenesis ISO
Inferred from Sequence Orthology
more info
 
atrial septum primum morphogenesis ISO
Inferred from Sequence Orthology
more info
 
atrial septum secundum morphogenesis IEA
Inferred from Electronic Annotation
more info
 
atrial septum secundum morphogenesis ISO
Inferred from Sequence Orthology
more info
 
atrioventricular canal development ISO
Inferred from Sequence Orthology
more info
 
atrioventricular valve formation ISO
Inferred from Sequence Orthology
more info
 
atrioventricular valve morphogenesis ISO
Inferred from Sequence Orthology
more info
 
canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
cardiac muscle cell differentiation IEP
Inferred from Expression Pattern
more info
PubMed 
cardiac muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
 
cardiac muscle hypertrophy in response to stress ISO
Inferred from Sequence Orthology
more info
 
cardiac muscle tissue development ISO
Inferred from Sequence Orthology
more info
 
cardiac muscle tissue regeneration ISO
Inferred from Sequence Orthology
more info
 
cardiac right ventricle morphogenesis ISO
Inferred from Sequence Orthology
more info
 
cardiac septum development ISO
Inferred from Sequence Orthology
more info
 
cell development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell fate commitment IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell growth involved in cardiac muscle cell development IDA
Inferred from Direct Assay
more info
PubMed 
cell-cell signaling ISO
Inferred from Sequence Orthology
more info
 
cellular response to follicle-stimulating hormone stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular response to glucose stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to gonadotropin stimulus ISO
Inferred from Sequence Orthology
more info
 
digestive tract development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
embryonic digestive tract morphogenesis ISO
Inferred from Sequence Orthology
more info
 
embryonic foregut morphogenesis ISO
Inferred from Sequence Orthology
more info
 
embryonic heart tube anterior/posterior pattern specification ISO
Inferred from Sequence Orthology
more info
 
embryonic heart tube development ISO
Inferred from Sequence Orthology
more info
 
embryonic morphogenesis ISO
Inferred from Sequence Orthology
more info
 
endocardial cushion development IEA
Inferred from Electronic Annotation
more info
 
endocardial cushion development ISO
Inferred from Sequence Orthology
more info
 
endoderm formation ISO
Inferred from Sequence Orthology
more info
 
epithelial cell fate commitment ISO
Inferred from Sequence Orthology
more info
 
gastrulation with mouth forming second ISO
Inferred from Sequence Orthology
more info
 
heart development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
heart development ISO
Inferred from Sequence Orthology
more info
 
heart development TAS
Traceable Author Statement
more info
PubMed 
heart looping ISO
Inferred from Sequence Orthology
more info
 
heart morphogenesis ISO
Inferred from Sequence Orthology
more info
 
in utero embryonic development ISO
Inferred from Sequence Orthology
more info
 
intestinal epithelial cell differentiation IEA
Inferred from Electronic Annotation
more info
 
intestinal epithelial cell differentiation ISO
Inferred from Sequence Orthology
more info
 
lung lobe formation ISO
Inferred from Sequence Orthology
more info
 
male gonad development IEA
Inferred from Electronic Annotation
more info
 
male gonad development ISO
Inferred from Sequence Orthology
more info
 
negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of autophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cardiac muscle cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of connective tissue replacement ISO
Inferred from Sequence Orthology
more info
 
negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
negative regulation of oxidative stress-induced cell death ISO
Inferred from Sequence Orthology
more info
 
positive regulation of BMP signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cardiac muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cardioblast differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
 
positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of vascular endothelial growth factor production ISO
Inferred from Sequence Orthology
more info
 
regulation of cardiac muscle cell contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cardiac muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
regulation of protein kinase B signaling ISO
Inferred from Sequence Orthology
more info
 
regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
response to drug IEA
Inferred from Electronic Annotation
more info
 
response to drug ISO
Inferred from Sequence Orthology
more info
 
response to estrogen ISO
Inferred from Sequence Orthology
more info
 
response to mechanical stimulus IDA
Inferred from Direct Assay
more info
PubMed 
response to retinoic acid ISO
Inferred from Sequence Orthology
more info
 
response to vitamin A IEP
Inferred from Expression Pattern
more info
PubMed 
seminiferous tubule development ISO
Inferred from Sequence Orthology
more info
 
signal transduction involved in regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
spermatogenesis ISO
Inferred from Sequence Orthology
more info
 
tissue development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
transdifferentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
tube morphogenesis ISO
Inferred from Sequence Orthology
more info
 
ventricular cardiac muscle tissue development ISO
Inferred from Sequence Orthology
more info
 
ventricular septum development ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
RNA polymerase II transcription factor complex IEA
Inferred from Electronic Annotation
more info
 
RNA polymerase II transcription factor complex ISO
Inferred from Sequence Orthology
more info
 
nuclear body IEA
Inferred from Electronic Annotation
more info
 
nuclear body ISO
Inferred from Sequence Orthology
more info
 
nuclear chromatin ISO
Inferred from Sequence Orthology
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
transcription factor GATA-4
Names
DNA-binding protein GATA-GT2
GATA-binding factor 4

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_144730.1NP_653331.1  transcription factor GATA-4

    See identical proteins and their annotated locations for NP_653331.1

    Status: PROVISIONAL

    Source sequence(s)
    L22761
    UniProtKB/Swiss-Prot
    P46152
    Related
    ENSRNOP00000014320.3, ENSRNOT00000014320.5
    Conserved Domains (3) summary
    smart00401
    Location:267314
    ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
    cd00202
    Location:269320
    ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
    pfam05349
    Location:1204
    GATA-N; GATA-type transcription activator, N-terminal

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005114.4 Reference Rnor_6.0 Primary Assembly

    Range
    46386703..46458679 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017599788.1XP_017455277.1  transcription factor GATA-4 isoform X1

    Conserved Domains (3) summary
    smart00401
    Location:268315
    ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
    cd00202
    Location:270321
    ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
    pfam05349
    Location:1204
    GATA-N; GATA-type transcription activator, N-terminal
  2. XM_006252189.3XP_006252251.1  transcription factor GATA-4 isoform X1

    Conserved Domains (3) summary
    smart00401
    Location:268315
    ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
    cd00202
    Location:270321
    ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
    pfam05349
    Location:1204
    GATA-N; GATA-type transcription activator, N-terminal
  3. XM_017599789.1XP_017455278.1  transcription factor GATA-4 isoform X1

    Conserved Domains (3) summary
    smart00401
    Location:268315
    ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
    cd00202
    Location:270321
    ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
    pfam05349
    Location:1204
    GATA-N; GATA-type transcription activator, N-terminal

Alternate Rn_Celera

Genomic

  1. AC_000083.1 Alternate Rn_Celera

    Range
    37143928..37189874 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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