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Cr1l complement C3b/C4b receptor 1 like [ Rattus norvegicus (Norway rat) ]

Gene ID: 54243, updated on 10-Feb-2026
Official Symbol
Cr1lprovided by RGD
Official Full Name
complement C3b/C4b receptor 1 likeprovided by RGD
Primary source
RGD:2399
See related
Ensembl:ENSRNOG00000008193 AllianceGenome:RGD:2399
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Cr1; Crry
Summary
This gene encodes a membrane-bound inhibitor of complement activation, which contains several tandemly arranged short consensus repeats (SCRs) of approximately 60 amino acids. The encoded protein may play a role in tumor immune surveillance, which is unrelated to complement inhibition. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Biased expression in Lung (RPKM 634.4), Thymus (RPKM 461.6) and 9 other tissues See more
Orthologs
all
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Try the new Transcripts and proteins table
See Cr1l in Genome Data Viewer
Location:
13q27
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (109138132..109189068, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (106606952..106660442, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (113824886..113872097, complement)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102550527 Neighboring gene microRNA 3556b Neighboring gene microRNA 29c Neighboring gene CD46 molecule Neighboring gene uncharacterized LOC108352604 Neighboring gene complement C3d receptor 2 Neighboring gene small nucleolar RNA SNORA17

Go to nucleotide: Graphics FASTA GenBank

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Related articles in PubMed

  1. Crry and CD59 regulate complement in rat glomerular epithelial cells and are inhibited by the nephritogenic antibody of passive Heymann nephritis. Quigg RJ, et al. J Immunol, 1995 Apr 1. PMID 7534798
  2. Molecular characterization of rat Crry: widespread distribution of two alternative forms of Crry mRNA. Quigg RJ, et al. Immunogenetics, 1995. PMID 7590969
  3. Molecular characterization of rat glomerular epithelial cell complement receptors. Quigg RJ, et al. J Am Soc Nephrol, 1994 May. PMID 7919144
  4. Structures of the rat complement regulator CrrY. Roversi P, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2011 Jul 1. PMID 21795784, Free PMC Article
  5. Molecular cloning of the rat complement regulatory protein, 5I2 antigen. Sakurada C, et al. Biochem Biophys Res Commun, 1994 Feb 15. PMID 8117286

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Hemopexin Modulates Expression of Complement Regulatory Proteins in Rat Glomeruli.
    Title: Hemopexin Modulates Expression of Complement Regulatory Proteins in Rat Glomeruli.
  2. structure of rat CrrY domains 1-4 has been determined in two distinct crystal forms and reveals a 70 degrees bend between domains 3 and 4
    Title: Structures of the rat complement regulator CrrY.
  3. X-ray and neutron scattering was performed on recombinant rat Crry containing the first five SCR domains (rCrry) and mouse Crry with five SCR domains conjugated to the Fc fragment of mouse IgG1 (mCrry-Ig)
    Title: The extended multidomain solution structures of the complement protein Crry and its chimeric conjugate Crry-Ig by scattering, analytical ultracentrifugation and constrained modelling: implications for function and therapy.
  4. Crry is involved in the LFA-1 dependent proliferation of thymocytes, a phenomenon that has not been recognized so far.
    Title: The role of rat Crry, a complement regulatory protein, in proliferation of thymocytes.
  5. Rat Crry on the surface of human tumor cell lines inhibited rat NK-cell-mediated ADCC. Anti-Crry enhanced NK-mediated ADCC in the absence of complement, suggesting a novel function for rat Crry in immune surveillance unrelated to complement inhibition.
    Title: Expression of rat complement control protein Crry on tumor cells inhibits rat natural killer cell-mediated cytotoxicity.
Submit: New GeneRIF Correction

Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in T cell mediated immunity IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cellular response to hypoxia ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within complement activation ISO
Inferred from Sequence Orthology
more info
  
involved_in complement activation, classical pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in female pregnancy IEA
Inferred from Electronic Annotation
more info
  
involved_in immune system process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within in utero embryonic development ISO
Inferred from Sequence Orthology
more info
  
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of complement activation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of complement activation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of complement activation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of complement activation, classical pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of complement activation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of complement-dependent cytotoxicity ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
located_in external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of receptor complex ISO
Inferred from Sequence Orthology
more info
  
Preferred Names
complement component receptor 1-like protein
Names
5I2 antigen
Complement receptor related protein
antigen 5I2
complement component (3b/4b) receptor 1-like
complement receptor type 1
complement regulatory protein Crry
complement regulatory protein Crry-like

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001005265.1 → NP_001005265.1  complement component receptor 1-like protein isoform 3 precursor

    See identical proteins and their annotated locations for NP_001005265.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an in-frame segment including two identical exons, as compared to variant 1. The encoded isoform 3 thus lacks an internal segment, which includes two short consensus repeats, as compared to isoform 1.
    Source sequence(s)
    CB707374, CB775511, D42114
    UniProtKB/TrEMBL
    A0A8L2UIA6
    Conserved Domains (3) summary
    cd00033
    Location:99 → 157
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    PHA02927
    Location:39 → 290
    PHA02927; secreted complement-binding protein; Provisional
    pfam00084
    Location:300 → 352
    Sushi; Sushi repeat (SCR repeat)

  2. NM_019301.2 → NP_062174.1  complement component receptor 1-like protein isoform 2 precursor

    See identical proteins and their annotated locations for NP_062174.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon, which is one of the three identical exons, as compared to variant 1. The encoded isoform 2 thus lacks an internal segment, or a short consensus repeat, as compared to isoform 1.
    Source sequence(s)
    CB707374, CB775511, D42114, L36532
    UniProtKB/Swiss-Prot
    Q63135, Q63612
    UniProtKB/TrEMBL
    A0A8I5ZT27
    Related
    ENSRNOP00000010798.8, ENSRNOT00000010799.8
    Conserved Domains (1) summary
    PHA02927
    Location:39 → 290
    PHA02927; secreted complement-binding protein; Provisional

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    109138132..109189068 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039091020.2 → XP_038946948.1  complement component receptor 1-like protein isoform X3

    UniProtKB/TrEMBL
    A0A0G2K7Y0, A0A8L2R7U2
    Related
    ENSRNOP00000074390.2, ENSRNOT00000079549.3
    Conserved Domains (1) summary
    PHA02927
    Location:39 → 290
    PHA02927; secreted complement-binding protein; Provisional

  2. XM_039091021.2 → XP_038946949.1  complement component receptor 1-like protein isoform X5

    UniProtKB/TrEMBL
    A0A8L2UIA6
    Conserved Domains (2) summary
    PHA02639
    Location:157 → 413
    PHA02639; EEV host range protein; Provisional
    PHA02927
    Location:39 → 290
    PHA02927; secreted complement-binding protein; Provisional

  3. XM_063272558.1 → XP_063128628.1  complement component receptor 1-like protein isoform X4

    UniProtKB/TrEMBL
    A0A8I5ZT27

  4. XM_039091019.2 → XP_038946947.1  complement component receptor 1-like protein isoform X2

    UniProtKB/TrEMBL
    A0A8I6GMN2, A0A8L2R7U2
    Related
    ENSRNOP00000097736.2, ENSRNOT00000120085.2
    Conserved Domains (1) summary
    PHA02927
    Location:39 → 290
    PHA02927; secreted complement-binding protein; Provisional

  5. XM_063272557.1 → XP_063128627.1  complement component receptor 1-like protein isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZT27
    Related
    ENSRNOP00000101783.1, ENSRNOT00000165602.1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001005330.1: Suppressed sequence

    Description
    NM_001005330.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q63135.1 GenPept UniProtKB/Swiss-Prot:Q63135

Gene LinkOut

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