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Cd160 CD160 antigen [ Mus musculus (house mouse) ]

Gene ID: 54215, updated on 8-Feb-2024

Summary

Official Symbol
Cd160provided by MGI
Official Full Name
CD160 antigenprovided by MGI
Primary source
MGI:MGI:1860383
See related
Ensembl:ENSMUSG00000038304 AllianceGenome:MGI:1860383
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
By55
Summary
Enables MHC class I protein complex binding activity. Involved in mucosal immune response; positive regulation of interferon-gamma production; and positive regulation of natural killer cell mediated immune response to tumor cell. Acts upstream of or within defense response to Gram-negative bacterium. Located in plasma membrane. Orthologous to human CD160 (CD160 molecule). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See Cd160 in Genome Data Viewer
Location:
3 F2.1; 3 41.99 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (96706079..96736667, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (96798763..96829351, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6085 Neighboring gene polymerase (RNA) III (DNA directed) polypeptide C Neighboring gene predicted gene, 22581 Neighboring gene ring finger protein 115 Neighboring gene RIKEN cDNA 4930442L01 gene Neighboring gene PDZ domain containing 1 Neighboring gene G protein-coupled receptor 89

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables MHC class I protein complex binding IDA
Inferred from Direct Assay
more info
PubMed 
enables MHC class I receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables MHC class Ib receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables activating MHC class I receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in T cell costimulation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within adaptive immune response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within defense response to Gram-negative bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in mucosal immune response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of CD4-positive, alpha-beta T cell costimulation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of T cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of adaptive immune memory response ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of endothelial cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of natural killer cell cytokine production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of natural killer cell degranulation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of natural killer cell mediated cytotoxicity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of natural killer cell mediated immune response to tumor cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of type II interferon production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of adaptive immune response IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in side of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
CD160 antigen
Names
natural killer cell BY55
natural killer cell receptor BY55

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163496.1NP_001156968.1  CD160 antigen isoform a precursor

    See identical proteins and their annotated locations for NP_001156968.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 both encode isoform a.
    Source sequence(s)
    AK139789
    Consensus CDS
    CCDS17648.1
    UniProtKB/Swiss-Prot
    O88875, Q8C9H4
    UniProtKB/TrEMBL
    Q8VC80
    Related
    ENSMUSP00000102689.2, ENSMUST00000107074.8
    Conserved Domains (2) summary
    smart00410
    Location:40125
    IG_like; Immunoglobulin like
    cl11960
    Location:38115
    Ig; Immunoglobulin domain
  2. NM_001163497.1NP_001156969.1  CD160 antigen isoform b precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AK139789, DV660330
    Consensus CDS
    CCDS51011.1
    UniProtKB/TrEMBL
    E9Q0X3
    Related
    ENSMUSP00000132363.2, ENSMUST00000165991.8
    Conserved Domains (2) summary
    smart00410
    Location:40125
    IG_like; Immunoglobulin like
    cl11960
    Location:38115
    Ig; Immunoglobulin domain
  3. NM_018767.3NP_061237.3  CD160 antigen isoform a precursor

    See identical proteins and their annotated locations for NP_061237.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode isoform a.
    Source sequence(s)
    AK042093, AK139789
    Consensus CDS
    CCDS17648.1
    UniProtKB/Swiss-Prot
    O88875, Q8C9H4
    UniProtKB/TrEMBL
    Q8VC80
    Related
    ENSMUSP00000037466.8, ENSMUST00000047702.8
    Conserved Domains (2) summary
    smart00410
    Location:40125
    IG_like; Immunoglobulin like
    cl11960
    Location:38115
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    96706079..96736667 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)