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TREM1 triggering receptor expressed on myeloid cells 1 [ Homo sapiens (human) ]

Gene ID: 54210, updated on 13-Jan-2019

Summary

Official Symbol
TREM1provided by HGNC
Official Full Name
triggering receptor expressed on myeloid cells 1provided by HGNC
Primary source
HGNC:HGNC:17760
See related
Ensembl:ENSG00000124731 MIM:605085
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CD354; TREM-1
Summary
This gene encodes a receptor belonging to the Ig superfamily that is expressed on myeloid cells. This protein amplifies neutrophil and monocyte-mediated inflammatory responses triggered by bacterial and fungal infections by stimulating release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jun 2011]
Expression
Biased expression in bone marrow (RPKM 10.0), appendix (RPKM 9.0) and 7 other tissues See more
Orthologs

Genomic context

See TREM1 in Genome Data Viewer
Location:
6p21.1
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 6 NC_000006.12 (41267385..41286745, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (41242999..41254457, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene RNA, 5S ribosomal pseudogene 207 Neighboring gene triggering receptor expressed on myeloid cells like 5, pseudogene Neighboring gene RNA, U6 small nuclear 643, pseudogene Neighboring gene ribosomal protein L32 pseudogene 15

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 upregulates the expression of triggering receptor expressed on myeloid cells 1 (TREM1) in peptide-treated PBMCs PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Adaptive Immune System, organism-specific biosystem (from REACTOME)
    Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
  • Cell surface interactions at the vascular wall, organism-specific biosystem (from REACTOME)
    Cell surface interactions at the vascular wall, organism-specific biosystemLeukocyte extravasation is a rigorously controlled process that guides white cell movement from the vascular lumen to sites of tissue inflammation. The powerful adhesive interactions that are require...
  • DAP12 interactions, organism-specific biosystem (from REACTOME)
    DAP12 interactions, organism-specific biosystemDNAX activation protein of 12kDa (DAP12) is an immunoreceptor tyrosine-based activation motif (ITAM)-bearing adapter molecule that transduces activating signals in natural killer (NK) and myeloid cel...
  • Hemostasis, organism-specific biosystem (from REACTOME)
    Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystem (from REACTOME)
    Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystemA number of receptors and cell adhesion molecules play a key role in modifying the response of cells of lymphoid origin (such as B-, T- and NK cells) to self and tumor antigens, as well as to pathoge...
  • Innate Immune System, organism-specific biosystem (from REACTOME)
    Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
  • Regulation of toll-like receptor signaling pathway, organism-specific biosystem (from WikiPathways)
    Regulation of toll-like receptor signaling pathway, organism-specific biosystem
    Regulation of toll-like receptor signaling pathway

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
scaffold protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acute inflammatory response IEA
Inferred from Electronic Annotation
more info
 
humoral immune response TAS
Traceable Author Statement
more info
PubMed 
innate immune response TAS
Traceable Author Statement
more info
 
intracellular signal transduction TAS
Traceable Author Statement
more info
PubMed 
leukocyte migration TAS
Traceable Author Statement
more info
 
regulation of immune response TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
extracellular region IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
triggering receptor expressed on myeloid cells 1
Names
triggering receptor expressed on monocytes 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029525.2 RefSeqGene

    Range
    4975..18115
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001242589.2NP_001229518.1  triggering receptor expressed on myeloid cells 1 isoform 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs at the 3' end compared to variant 1. This results in a shorter isoform (2) with a distinct C-terminus, lacking the transmembrane domain, compared to isoform 1.
    Source sequence(s)
    AF287008, AK223264, DC428714
    Consensus CDS
    CCDS59499.1
    UniProtKB/Swiss-Prot
    Q9NP99
    Related
    ENSP00000465345.1, ENST00000591620.1
    Conserved Domains (1) summary
    cl11960
    Location:33118
    Ig; Immunoglobulin domain
  2. NM_001242590.2NP_001229519.1  triggering receptor expressed on myeloid cells 1 isoform 3 precursor

    See identical proteins and their annotated locations for NP_001229519.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3; also known as TREM1-sv, PMID:11922939) is missing an internal coding exon compared to variant 1. This results in a frame-shift, and a shorter isoform (3) with a distinct C-terminus compared to isoform 1. This isoform, lacking the transmembrane domain, is likely secreted, and may function as a regulator of myeloid activation (PMID:11922939).
    Source sequence(s)
    AK301519, AL391903, CA417244, DA362458, DA938757, DC428714
    Consensus CDS
    CCDS56427.1
    UniProtKB/Swiss-Prot
    Q9NP99
    Related
    ENSP00000334284.5, ENST00000334475.10
    Conserved Domains (2) summary
    smart00410
    Location:27133
    IG_like; Immunoglobulin like
    cl11960
    Location:32134
    Ig; Immunoglobulin domain
  3. NM_018643.5NP_061113.1  triggering receptor expressed on myeloid cells 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_061113.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AF287008, AL391903, CA417244, DA362458, DA938757
    Consensus CDS
    CCDS4854.1
    UniProtKB/Swiss-Prot
    Q9NP99
    UniProtKB/TrEMBL
    Q38L15
    Related
    ENSP00000244709.3, ENST00000244709.8
    Conserved Domains (1) summary
    cl11960
    Location:33118
    Ig; Immunoglobulin domain

RNA

  1. NR_136332.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate 5' and 3' exon structure, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AF287008, AL391903, AW264786, BI910026, DA362458, DA938757, DC428714

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p12 Primary Assembly

    Range
    41267385..41286745 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011514696.2XP_011512998.1  triggering receptor expressed on myeloid cells 1 isoform X1

    See identical proteins and their annotated locations for XP_011512998.1

    UniProtKB/TrEMBL
    K7EKM5
    Related
    ENSP00000465688.1, ENST00000589614.5
    Conserved Domains (1) summary
    cl11960
    Location:33118
    Ig; Immunoglobulin domain
  2. XM_017010956.2XP_016866445.1  triggering receptor expressed on myeloid cells 1 isoform X2

    UniProtKB/Swiss-Prot
    Q9NP99
    UniProtKB/TrEMBL
    Q38L15
    Conserved Domains (1) summary
    cl11960
    Location:33118
    Ig; Immunoglobulin domain
  3. XM_017010957.1XP_016866446.1  triggering receptor expressed on myeloid cells 1 isoform X3

    UniProtKB/Swiss-Prot
    Q9NP99
    Conserved Domains (2) summary
    smart00410
    Location:27133
    IG_like; Immunoglobulin like
    cl11960
    Location:32134
    Ig; Immunoglobulin domain
  4. XM_006715117.3XP_006715180.1  triggering receptor expressed on myeloid cells 1 isoform X4

    Conserved Domains (2) summary
    smart00410
    Location:27133
    IG_like; Immunoglobulin like
    cl11960
    Location:32134
    Ig; Immunoglobulin domain
  5. XM_011514697.1XP_011512999.1  triggering receptor expressed on myeloid cells 1 isoform X5

    Conserved Domains (2) summary
    smart00410
    Location:27133
    IG_like; Immunoglobulin like
    cl11960
    Location:32134
    Ig; Immunoglobulin domain
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