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KCNK10 potassium two pore domain channel subfamily K member 10 [ Homo sapiens (human) ]

Gene ID: 54207, updated on 1-Jun-2020

Summary

Official Symbol
KCNK10provided by HGNC
Official Full Name
potassium two pore domain channel subfamily K member 10provided by HGNC
Primary source
HGNC:HGNC:6273
See related
Ensembl:ENSG00000100433 MIM:605873
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TREK2; TREK-2; K2p10.1; PPP1R97
Summary
The protein encoded by this gene belongs to the family of potassium channel proteins containing two pore-forming P domains. This channel is an open rectifier which primarily passes outward current under physiological K+ concentrations, and is stimulated strongly by arachidonic acid and to a lesser degree by membrane stretching, intracellular acidification, and general anaesthetics. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Sep 2008]
Expression
Biased expression in brain (RPKM 1.7), duodenum (RPKM 1.4) and 8 other tissues See more
Orthologs

Genomic context

See KCNK10 in Genome Data Viewer
Location:
14q31.3
Exon count:
11
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (88180108..88326912, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (88646452..88793256, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984699 Neighboring gene uncharacterized LOC105370613 Neighboring gene uncharacterized LOC105370612 Neighboring gene spermatogenesis associated 7 Neighboring gene protein tyrosine phosphatase non-receptor type 21 Neighboring gene uncharacterized LOC105370614 Neighboring gene RNA, U4 small nuclear 22, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide genetic and transcriptomic investigation of variation in antibody response to dietary antigens.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ43399

Gene Ontology Provided by GOA

Function Evidence Code Pubs
potassium channel activity TAS
Traceable Author Statement
more info
PubMed 
potassium ion leak channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
voltage-gated ion channel activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
memory IEA
Inferred from Electronic Annotation
more info
 
potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
signal transduction NAS
Non-traceable Author Statement
more info
PubMed 
stabilization of membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
potassium channel subfamily K member 10
Names
2P domain potassium channel TREK2
TREK-2 K(+) channel subunit
TWIK-related K+ channel 2
outward rectifying potassium channel protein TREK-2
potassium channel TREK-2
potassium channel, subfamily K, member 10
potassium channel, two pore domain subfamily K, member 10
protein phosphatase 1, regulatory subunit 97

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021161.4NP_066984.1  potassium channel subfamily K member 10 isoform 1 precursor

    See identical proteins and their annotated locations for NP_066984.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1, also known as TREK2 splice variant a) encodes the shortest isoform (1).
    Source sequence(s)
    AF279890, AI693366, AL049834, AL133279, U79244
    Consensus CDS
    CCDS9880.1
    UniProtKB/Swiss-Prot
    P57789
    Related
    ENSP00000343104.5, ENST00000340700.9
    Conserved Domains (1) summary
    pfam07885
    Location:148206
    Ion_trans_2; Ion channel
  2. NM_138317.3NP_612190.1  potassium channel subfamily K member 10 isoform 2

    See identical proteins and their annotated locations for NP_612190.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2, also known as TREK2 splice variant c) has a different 5' terminal exon compared to transcript variant 1, and encodes a slightly longer isoform (2) with a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AF279890, AI693366, AK313499, AL049834, AL133279, EU978939, U79244
    Consensus CDS
    CCDS9881.1
    UniProtKB/Swiss-Prot
    P57789
    Related
    ENSP00000312811.5, ENST00000319231.9
    Conserved Domains (1) summary
    pfam07885
    Location:153211
    Ion_trans_2; Ion channel
  3. NM_138318.2NP_612191.1  potassium channel subfamily K member 10 isoform 3

    See identical proteins and their annotated locations for NP_612191.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3, also known as TREK2 splice variant b) has a different 5' terminal exon compared to transcript variant 1, and encodes a slightly longer isoform (3) with a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AF279890, AF385399, AI693366, AL133279, BC075021, EU978940, U79244
    Consensus CDS
    CCDS9882.1
    UniProtKB/Swiss-Prot
    P57789
    Related
    ENSP00000310568.5, ENST00000312350.9
    Conserved Domains (1) summary
    pfam07885
    Location:153211
    Ion_trans_2; Ion channel

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    88180108..88326912 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024449628.1XP_024305396.1  potassium channel subfamily K member 10 isoform X1

    Conserved Domains (1) summary
    pfam07885
    Location:94152
    Ion_trans_2; Ion channel
  2. XM_011536840.2XP_011535142.1  potassium channel subfamily K member 10 isoform X2

    Conserved Domains (1) summary
    pfam07885
    Location:2078
    Ion_trans_2; Ion channel
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