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Septin1 septin 1 [ Mus musculus (house mouse) ]

Gene ID: 54204, updated on 11-Jan-2023

Summary

Official Symbol
Septin1provided by MGI
Official Full Name
septin 1provided by MGI
Primary source
MGI:MGI:1858916
See related
Ensembl:ENSMUSG00000000486 AllianceGenome:MGI:1858916
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Diff6; Sept1; Pnutl3
Summary
Predicted to enable GTPase activity; identical protein binding activity; and molecular adaptor activity. Acts upstream of or within meiotic metaphase plate congression and spindle assembly involved in female meiosis. Located in meiotic spindle and midbody. Is expressed in thymus primordium. Orthologous to human SEPTIN1 (septin 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in thymus adult (RPKM 117.3), spleen adult (RPKM 47.0) and 1 other tissue See more
Orthologs
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Genomic context

See Septin1 in Genome Data Viewer
Location:
7; 7 F3
Exon count:
12
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (126811881..126832157, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (127212709..127232985, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene CD2 cytoplasmic tail binding protein 2 Neighboring gene TBC1 domain family, member 10b Neighboring gene myosin light chain, phosphorylatable, fast skeletal muscle Neighboring gene predicted gene 4532 Neighboring gene zinc finger protein 553 Neighboring gene zinc finger protein 771

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables molecular adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in cytoskeleton-dependent cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within meiotic metaphase plate congression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within spindle assembly involved in female meiosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in cell division site IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in meiotic spindle IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in microtubule cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in midbody IDA
Inferred from Direct Assay
more info
PubMed 
located_in midbody ISO
Inferred from Sequence Orthology
more info
 
part_of septin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in septin ring IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in synaptic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
septin-1
Names
differentiation 6 (deoxyguanosine triphosphate triphosphohydrolase)
differentiation protein 6
peanut-like protein 3
protein Diff6
NP_059489.2
XP_006508092.1
XP_006508093.1
XP_006508094.1
XP_011240164.1
XP_036009143.1
XP_036009144.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017461.3NP_059489.2  septin-1

    See identical proteins and their annotated locations for NP_059489.2

    Status: VALIDATED

    Source sequence(s)
    AC122537
    Consensus CDS
    CCDS40141.1
    UniProtKB/Swiss-Prot
    B2RU74, P42209
    UniProtKB/TrEMBL
    A0A8C6IHN5
    Related
    ENSMUSP00000101921.2, ENSMUST00000106314.8
    Conserved Domains (2) summary
    COG5019
    Location:5348
    CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    pfam00735
    Location:22295
    Septin; Septin

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    126811881..126832157 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006508029.5XP_006508092.1  septin-1 isoform X1

    See identical proteins and their annotated locations for XP_006508092.1

    Conserved Domains (1) summary
    pfam00735
    Location:22378
    Septin
  2. XM_011241862.2XP_011240164.1  septin-1 isoform X1

    See identical proteins and their annotated locations for XP_011240164.1

    Conserved Domains (1) summary
    pfam00735
    Location:22378
    Septin
  3. XM_006508030.4XP_006508093.1  septin-1 isoform X2

    See identical proteins and their annotated locations for XP_006508093.1

    UniProtKB/TrEMBL
    A0A8C6IFL0, D3Z3V3
    Conserved Domains (1) summary
    pfam00735
    Location:1274
    Septin
  4. XM_036153251.1XP_036009144.1  septin-1 isoform X4

    Conserved Domains (1) summary
    cl40481
    Location:11119
    YlqF_related_GTPase; Circularly permuted YlqF-related GTPases
  5. XM_006508031.4XP_006508094.1  septin-1 isoform X2

    See identical proteins and their annotated locations for XP_006508094.1

    UniProtKB/TrEMBL
    A0A8C6IFL0, D3Z3V3
    Related
    ENSMUSP00000101920.2, ENSMUST00000106313.8
    Conserved Domains (1) summary
    pfam00735
    Location:1274
    Septin
  6. XM_036153250.1XP_036009143.1  septin-1 isoform X3

    Conserved Domains (1) summary
    cl40481
    Location:23296
    YlqF_related_GTPase; Circularly permuted YlqF-related GTPases

RNA

  1. XR_003946520.2 RNA Sequence