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Ccrl2 chemokine (C-C motif) receptor-like 2 [ Mus musculus (house mouse) ]

Gene ID: 54199, updated on 8-Dec-2022

Summary

Official Symbol
Ccrl2provided by MGI
Official Full Name
chemokine (C-C motif) receptor-like 2provided by MGI
Primary source
MGI:MGI:1920904
See related
Ensembl:ENSMUSG00000043953 AllianceGenome:MGI:1920904
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
E01; Ackr5; CCR11; L-CCR; Cmkbr1l2; 1810047I05Rik
Summary
Enables chemokine receptor binding activity. Involved in inflammatory response. Predicted to be integral component of plasma membrane. Predicted to be active in cytoplasm and external side of plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; immune system; and liver and biliary system. Orthologous to human CCRL2 (C-C motif chemokine receptor like 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in lung adult (RPKM 16.6), placenta adult (RPKM 10.7) and 17 other tissues See more
Orthologs
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Genomic context

See Ccrl2 in Genome Data Viewer
Location:
9 F2; 9 60.92 cM
Exon count:
3
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (110883902..110886586, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (111054834..111057518, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene receptor transporter protein 3 Neighboring gene predicted gene 10030 Neighboring gene lactotransferrin Neighboring gene ribosomal protein L31, pseudogene 19 Neighboring gene predicted gene, 26409

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables C-C chemokine receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables CCR chemokine receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables chemokine receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables chemokine receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables chemokine receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
acts_upstream_of_or_within chemokine-mediated signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in chemotaxis IEA
Inferred from Electronic Annotation
more info
 
involved_in immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in inflammatory response IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
C-C chemokine receptor-like 2
Names
G-protein coupled beta chemokine receptor
chemokine (C-C) receptor 1-like 2
chemokine receptor CCR11
lipopolysaccharide inducible C-C chemokine receptor related
lipopolysaccharide-inducible C-C chemokine receptor
lipopolysacharide-inducible C-C chemokine receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001302376.1NP_001289305.1  C-C chemokine receptor-like 2

    See identical proteins and their annotated locations for NP_001289305.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AK007808, AK145946, BC038631, BY162594
    Consensus CDS
    CCDS23582.1
    UniProtKB/Swiss-Prot
    O35457, Q91YD7
    Related
    ENSMUSP00000143116.2, ENSMUST00000199839.5
    Conserved Domains (1) summary
    cd15171
    Location:38316
    7tmA_CCRL2; CC chemokine receptor-like 2, member of the class A family of seven-transmembrane G protein-coupled receptors
  2. NM_001302377.1NP_001289306.1  C-C chemokine receptor-like 2

    See identical proteins and their annotated locations for NP_001289306.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC118727, AK007808, AK145946, BC038631, BY162594
    Consensus CDS
    CCDS23582.1
    UniProtKB/Swiss-Prot
    O35457, Q91YD7
    Conserved Domains (1) summary
    cd15171
    Location:38316
    7tmA_CCRL2; CC chemokine receptor-like 2, member of the class A family of seven-transmembrane G protein-coupled receptors
  3. NM_017466.5NP_059494.2  C-C chemokine receptor-like 2

    See identical proteins and their annotated locations for NP_059494.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AK007808, AK145946, BC038631
    Consensus CDS
    CCDS23582.1
    UniProtKB/Swiss-Prot
    O35457, Q91YD7
    Related
    ENSMUSP00000107519.2, ENSMUST00000111888.3
    Conserved Domains (1) summary
    cd15171
    Location:38316
    7tmA_CCRL2; CC chemokine receptor-like 2, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    110883902..110886586 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)