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Snx3 sorting nexin 3 [ Mus musculus (house mouse) ]

Gene ID: 54198, updated on 12-May-2024

Summary

Official Symbol
Snx3provided by MGI
Official Full Name
sorting nexin 3provided by MGI
Primary source
MGI:MGI:1860188
See related
Ensembl:ENSMUSG00000019804 AllianceGenome:MGI:1860188
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SDP3
Summary
Enables phosphatidylinositol phosphate binding activity. Involved in positive regulation of neuron projection development. Acts upstream of or within several processes, including hemoglobin biosynthetic process; regulation of intracellular protein transport; and transferrin transport. Predicted to be located in cytoplasmic vesicle and cytosol. Predicted to be part of retromer complex. Predicted to be active in early endosome membrane. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in syndromic microphthalmia 8. Orthologous to human SNX3 (sorting nexin 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 150.6), testis adult (RPKM 118.9) and 28 other tissues See more
Orthologs
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Genomic context

See Snx3 in Genome Data Viewer
Location:
10 B2; 10 22.89 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (42378050..42411365)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (42502054..42535369)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene forkhead box O3 Neighboring gene STARR-seq mESC enhancer starr_26482 Neighboring gene STARR-seq mESC enhancer starr_26483 Neighboring gene STARR-seq mESC enhancer starr_26484 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:41989470-41989671 Neighboring gene predicted gene, 38485 Neighboring gene STARR-positive B cell enhancer ABC_E5129 Neighboring gene AFG1 like ATPase Neighboring gene STARR-seq mESC enhancer starr_26488 Neighboring gene STARR-positive B cell enhancer ABC_E2322 Neighboring gene STARR-seq mESC enhancer starr_26490 Neighboring gene nuclear receptor subfamily 2, group E, member 1 Neighboring gene predicted gene, 38491

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC151262, MGC151266

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables lipid binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidylinositol binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidylinositol phosphate binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidylinositol-3,5-bisphosphate binding IDA
Inferred from Direct Assay
more info
PubMed 
enables phosphatidylinositol-3-phosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables phosphatidylinositol-3-phosphate binding IDA
Inferred from Direct Assay
more info
PubMed 
enables phosphatidylinositol-3-phosphate binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphatidylinositol-4-phosphate binding IDA
Inferred from Direct Assay
more info
PubMed 
enables phosphatidylinositol-5-phosphate binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
 
enables retromer complex binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in endocytic recycling IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within heme biosynthetic process ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within hemoglobin biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intralumenal vesicle formation ISO
Inferred from Sequence Orthology
more info
 
involved_in late endosome to Golgi transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in membrane invagination ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of early endosome to late endosome transport ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of phagocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein transport ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of viral entry into host cell ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neuron projection development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein to membrane docking ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of intracellular protein transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of protein metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to bacterium ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within transferrin transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in clathrin-coated vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in early endosome ISO
Inferred from Sequence Orthology
more info
 
is_active_in early endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in early endosome membrane ISO
Inferred from Sequence Orthology
more info
 
located_in early phagosome ISO
Inferred from Sequence Orthology
more info
 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
located_in endosome membrane ISO
Inferred from Sequence Orthology
more info
 
part_of retromer complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of retromer complex ISO
Inferred from Sequence Orthology
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017472.4NP_059500.2  sorting nexin-3

    See identical proteins and their annotated locations for NP_059500.2

    Status: VALIDATED

    Source sequence(s)
    AK007798, AK013183, DN176987
    Consensus CDS
    CCDS23812.1
    UniProtKB/Swiss-Prot
    O70492
    UniProtKB/TrEMBL
    Q78ZM0
    Related
    ENSMUSP00000019939.6, ENSMUST00000019939.12
    Conserved Domains (1) summary
    cd07293
    Location:28150
    PX_SNX3; The phosphoinositide binding Phox Homology domain of Sorting Nexin 3

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    42378050..42411365
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)