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Pabpn1 poly(A) binding protein, nuclear 1 [ Mus musculus (house mouse) ]

Gene ID: 54196, updated on 27-Nov-2024

Summary

Official Symbol
Pabpn1provided by MGI
Official Full Name
poly(A) binding protein, nuclear 1provided by MGI
Primary source
MGI:MGI:1859158
See related
Ensembl:ENSMUSG00000022194 AllianceGenome:MGI:1859158
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PAB2; Pabp3; mPABII
Summary
Enables RNA polymerase binding activity. Involved in MAPK cascade; cellular response to lipopolysaccharide; and positive regulation of polynucleotide adenylyltransferase activity. Located in nucleus. Part of ribonucleoprotein complex. Is expressed in central nervous system; sensory organ; and thymus. Used to study oculopharyngeal muscular dystrophy. Human ortholog(s) of this gene implicated in oculopharyngeal muscular dystrophy. Orthologous to human PABPN1 (poly(A) binding protein nuclear 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in whole brain E14.5 (RPKM 169.0), CNS E14 (RPKM 167.7) and 28 other tissues See more
Orthologs
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Genomic context

See Pabpn1 in Genome Data Viewer
Location:
14 C3; 14 27.98 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (55131600..55136384)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (54894143..54898927)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene protein phosphatase 1, regulatory subunit 3E Neighboring gene BCL2-like 2 Neighboring gene STARR-positive B cell enhancer ABC_E754 Neighboring gene solute carrier family 22 (organic cation transporter), member 17 Neighboring gene embryonal Fyn-associated substrate Neighboring gene STARR-seq mESC enhancer starr_36750 Neighboring gene interleukin 25

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA polymerase binding IDA
Inferred from Direct Assay
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
PubMed 
enables poly(A) binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables poly(A) binding TAS
Traceable Author Statement
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in nuclear inclusion body ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear inclusion body ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
part_of ribonucleoprotein complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of ribonucleoprotein complex ISO
Inferred from Sequence Orthology
more info
 
part_of ribonucleoprotein complex ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
polyadenylate-binding protein 2
Names
PABII
PABP-2
nuclear poly(A)-binding protein 1
poly(A) binding protein II
poly(A)-binding protein 2
polyadenylate-binding nuclear protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019402.2NP_062275.1  polyadenylate-binding protein 2

    See identical proteins and their annotated locations for NP_062275.1

    Status: VALIDATED

    Source sequence(s)
    AC116591, AK032172, BY266376
    Consensus CDS
    CCDS27104.1
    UniProtKB/Swiss-Prot
    O35935, Q8CCS6
    UniProtKB/TrEMBL
    G3UY42
    Related
    ENSMUSP00000022808.8, ENSMUST00000022808.14
    Conserved Domains (2) summary
    COG0724
    Location:109285
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12550
    Location:169244
    RRM_II_PABPN1; RNA recognition motif in type II polyadenylate-binding protein 2 (PABP-2) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    55131600..55136384
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)