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Kat6b K(lysine) acetyltransferase 6B [ Mus musculus (house mouse) ]

Gene ID: 54169, updated on 8-Dec-2022

Summary

Official Symbol
Kat6bprovided by MGI
Official Full Name
K(lysine) acetyltransferase 6Bprovided by MGI
Primary source
MGI:MGI:1858746
See related
Ensembl:ENSMUSG00000021767 AllianceGenome:MGI:1858746
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
qkf; Morf; Myst4; MYST-4; querkopf; mKIAA0383; B130044K16Rik
Summary
Enables histone acetyltransferase activity. Acts upstream of or within cellular response to leukemia inhibitory factor and histone acetylation. Predicted to be located in nucleus. Predicted to be part of MOZ/MORF histone acetyltransferase complex. Is expressed in several structures, including brain; early conceptus; facial prominence; genitourinary system; and limb mesenchyme. Used to study Noonan syndrome. Human ortholog(s) of this gene implicated in bipolar disorder; blepharophimosis-intellectual disability syndrome, SBBYS type; breast cancer; and leiomyoma. Orthologous to human KAT6B (lysine acetyltransferase 6B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in limb E14.5 (RPKM 5.4), frontal lobe adult (RPKM 5.1) and 28 other tissues See more
Orthologs
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Genomic context

See Kat6b in Genome Data Viewer
Location:
14; 14 A3
Exon count:
22
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (21549284..21722546)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (21499216..21672478)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene adenosine kinase Neighboring gene VISTA enhancer mm1738 Neighboring gene predicted gene, 30363 Neighboring gene VISTA enhancer mm1600 Neighboring gene dual specificity phosphatase 29

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1)  1 citation
  • Targeted (1) 
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3K14 acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables histone acetyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables histone acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables peptide-lysine-N-acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of MOZ/MORF histone acetyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of MOZ/MORF histone acetyltransferase complex ISO
Inferred from Sequence Orthology
more info
 
part_of nucleosome IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
histone acetyltransferase KAT6B
Names
MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4
MYST histone acetyltransferase monocytic leukemia 4
histone acetyltransferase MYST4
histone acetyltransferase querkopf
monocytic leukemia
protein querkopf
NP_001192170.1
NP_059507.2
XP_006519326.1
XP_006519327.1
XP_006519328.1
XP_006519331.1
XP_006519332.1
XP_017171571.1
XP_017171572.1
XP_017171573.1
XP_030103747.1
XP_030103748.1
XP_036014649.1
XP_036014650.1
XP_036014651.1
XP_036014652.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001205241.2NP_001192170.1  histone acetyltransferase KAT6B isoform 1

    See identical proteins and their annotated locations for NP_001192170.1

    Status: VALIDATED

    Source sequence(s)
    AC115122, AC148978
    Consensus CDS
    CCDS59615.1
    UniProtKB/TrEMBL
    Q3UH94
    Related
    ENSMUSP00000138511.2, ENSMUST00000182855.8
    Conserved Domains (4) summary
    smart00526
    Location:94168
    H15; Domain in histone families 1 and 5
    PLN00104
    Location:430698
    PLN00104; MYST -like histone acetyltransferase; Provisional
    cd15527
    Location:272318
    PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
    cd15689
    Location:213271
    PHD1_MORF; PHD finger 1 found in monocytic leukemia zinc finger protein-related factor (MORF)
  2. NM_001408695.1NP_001395624.1  histone acetyltransferase KAT6B isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC115122, AC148978
  3. NM_001408696.1NP_001395625.1  histone acetyltransferase KAT6B isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC115122, AC148978
    UniProtKB/Swiss-Prot
    Q9JKX5
  4. NM_017479.4NP_059507.2  histone acetyltransferase KAT6B isoform 1

    See identical proteins and their annotated locations for NP_059507.2

    Status: VALIDATED

    Source sequence(s)
    AC115122, AC148978
    Consensus CDS
    CCDS59615.1
    UniProtKB/Swiss-Prot
    Q8BRB7
    UniProtKB/TrEMBL
    Q501M5
    Related
    ENSMUSP00000138377.2, ENSMUST00000182405.9
    Conserved Domains (4) summary
    smart00526
    Location:94168
    H15; Domain in histone families 1 and 5
    PLN00104
    Location:430698
    PLN00104; MYST -like histone acetyltransferase; Provisional
    cd15527
    Location:272318
    PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
    cd15689
    Location:213271
    PHD1_MORF; PHD finger 1 found in monocytic leukemia zinc finger protein-related factor (MORF)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    21549284..21722546
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006519265.5XP_006519328.1  histone acetyltransferase KAT6B isoform X1

    See identical proteins and their annotated locations for XP_006519328.1

    UniProtKB/TrEMBL
    A0A5F8MQ39
    Conserved Domains (4) summary
    smart00526
    Location:94168
    H15; Domain in histone families 1 and 5
    PLN00104
    Location:721989
    PLN00104; MYST -like histone acetyltransferase; Provisional
    cd15527
    Location:272318
    PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
    cd15618
    Location:213270
    PHD1_MOZ_MORF; PHD finger 1 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
  2. XM_036158758.1XP_036014651.1  histone acetyltransferase KAT6B isoform X6

    Conserved Domains (4) summary
    smart00526
    Location:94168
    H15; Domain in histone families 1 and 5
    PLN00104
    Location:430698
    PLN00104; MYST -like histone acetyltransferase; Provisional
    cd15527
    Location:272318
    PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
    cd15689
    Location:213271
    PHD1_MORF; PHD finger 1 found in monocytic leukemia zinc finger protein-related factor (MORF)
  3. XM_006519264.5XP_006519327.1  histone acetyltransferase KAT6B isoform X1

    See identical proteins and their annotated locations for XP_006519327.1

    UniProtKB/TrEMBL
    A0A5F8MQ39
    Conserved Domains (4) summary
    smart00526
    Location:94168
    H15; Domain in histone families 1 and 5
    PLN00104
    Location:721989
    PLN00104; MYST -like histone acetyltransferase; Provisional
    cd15527
    Location:272318
    PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
    cd15618
    Location:213270
    PHD1_MOZ_MORF; PHD finger 1 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
  4. XM_036158756.1XP_036014649.1  histone acetyltransferase KAT6B isoform X1

    UniProtKB/TrEMBL
    A0A5F8MQ39
    Related
    ENSMUSP00000159058.2, ENSMUST00000238837.2
    Conserved Domains (4) summary
    smart00526
    Location:94168
    H15; Domain in histone families 1 and 5
    PLN00104
    Location:721989
    PLN00104; MYST -like histone acetyltransferase; Provisional
    cd15527
    Location:272318
    PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
    cd15618
    Location:213270
    PHD1_MOZ_MORF; PHD finger 1 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
  5. XM_036158759.1XP_036014652.1  histone acetyltransferase KAT6B isoform X7

    Conserved Domains (4) summary
    smart00526
    Location:94168
    H15; Domain in histone families 1 and 5
    PLN00104
    Location:367635
    PLN00104; MYST -like histone acetyltransferase; Provisional
    cd15527
    Location:272310
    PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
    cd15689
    Location:213271
    PHD1_MORF; PHD finger 1 found in monocytic leukemia zinc finger protein-related factor (MORF)
  6. XM_030247887.2XP_030103747.1  histone acetyltransferase KAT6B isoform X1

    UniProtKB/TrEMBL
    A0A5F8MQ39
    Conserved Domains (4) summary
    smart00526
    Location:94168
    H15; Domain in histone families 1 and 5
    PLN00104
    Location:721989
    PLN00104; MYST -like histone acetyltransferase; Provisional
    cd15527
    Location:272318
    PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
    cd15618
    Location:213270
    PHD1_MOZ_MORF; PHD finger 1 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
  7. XM_017316082.3XP_017171571.1  histone acetyltransferase KAT6B isoform X2

    Conserved Domains (4) summary
    smart00526
    Location:94168
    H15; Domain in histone families 1 and 5
    PLN00104
    Location:721989
    PLN00104; MYST -like histone acetyltransferase; Provisional
    cd15527
    Location:272318
    PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
    cd15618
    Location:213270
    PHD1_MOZ_MORF; PHD finger 1 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
  8. XM_006519263.5XP_006519326.1  histone acetyltransferase KAT6B isoform X1

    See identical proteins and their annotated locations for XP_006519326.1

    UniProtKB/TrEMBL
    A0A5F8MQ39
    Conserved Domains (4) summary
    smart00526
    Location:94168
    H15; Domain in histone families 1 and 5
    PLN00104
    Location:721989
    PLN00104; MYST -like histone acetyltransferase; Provisional
    cd15527
    Location:272318
    PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
    cd15618
    Location:213270
    PHD1_MOZ_MORF; PHD finger 1 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
  9. XM_036158757.1XP_036014650.1  histone acetyltransferase KAT6B isoform X3

    Conserved Domains (4) summary
    smart00526
    Location:94168
    H15; Domain in histone families 1 and 5
    PLN00104
    Location:584852
    PLN00104; MYST -like histone acetyltransferase; Provisional
    cd15527
    Location:272318
    PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
    cd15618
    Location:213270
    PHD1_MOZ_MORF; PHD finger 1 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
  10. XM_006519268.5XP_006519331.1  histone acetyltransferase KAT6B isoform X4

    UniProtKB/Swiss-Prot
    Q8BRB7
    Related
    ENSMUSP00000138421.2, ENSMUST00000182964.3
    Conserved Domains (4) summary
    smart00526
    Location:94168
    H15; Domain in histone families 1 and 5
    PLN00104
    Location:539807
    PLN00104; MYST -like histone acetyltransferase; Provisional
    cd15527
    Location:272318
    PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
    cd15689
    Location:213271
    PHD1_MORF; PHD finger 1 found in monocytic leukemia zinc finger protein-related factor (MORF)
  11. XM_017316083.3XP_017171572.1  histone acetyltransferase KAT6B isoform X6

    UniProtKB/Swiss-Prot
    Q8BRB7
    Conserved Domains (4) summary
    smart00526
    Location:94168
    H15; Domain in histone families 1 and 5
    PLN00104
    Location:430698
    PLN00104; MYST -like histone acetyltransferase; Provisional
    cd15527
    Location:272318
    PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
    cd15689
    Location:213271
    PHD1_MORF; PHD finger 1 found in monocytic leukemia zinc finger protein-related factor (MORF)
  12. XM_017316084.3XP_017171573.1  histone acetyltransferase KAT6B isoform X7

    Conserved Domains (4) summary
    smart00526
    Location:94168
    H15; Domain in histone families 1 and 5
    PLN00104
    Location:367635
    PLN00104; MYST -like histone acetyltransferase; Provisional
    cd15527
    Location:272310
    PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
    cd15689
    Location:213271
    PHD1_MORF; PHD finger 1 found in monocytic leukemia zinc finger protein-related factor (MORF)
  13. XM_006519269.5XP_006519332.1  histone acetyltransferase KAT6B isoform X5

    Conserved Domains (2) summary
    PLN00104
    Location:436704
    PLN00104; MYST -like histone acetyltransferase; Provisional
    cd15527
    Location:133
    PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
  14. XM_030247888.2XP_030103748.1  histone acetyltransferase KAT6B isoform X8

    Conserved Domains (1) summary
    PLN00104
    Location:557
    PLN00104; MYST -like histone acetyltransferase; Provisional