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Rnase2b ribonuclease, RNase A family, 2B (liver, eosinophil-derived neurotoxin) [ Mus musculus (house mouse) ]

Gene ID: 54159, updated on 26-Sep-2022

Summary

Official Symbol
Rnase2bprovided by MGI
Official Full Name
ribonuclease, RNase A family, 2B (liver, eosinophil-derived neurotoxin)provided by MGI
Primary source
MGI:MGI:1858598
See related
Ensembl:ENSMUSG00000059606 AllianceGenome:MGI:1858598
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mR5; Ear5; Raf4
Summary
Predicted to enable ribonuclease activity. Predicted to be involved in chemotaxis and innate immune response in mucosa. Predicted to be active in extracellular space. Orthologous to human RNASE2 (ribonuclease A family member 2) and RNASE3 (ribonuclease A family member 3). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See Rnase2b in Genome Data Viewer
Location:
14; 14 C1
Exon count:
1
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (51399717..51400475)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (51162260..51163018)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene ribonuclease, RNase A family, 6 Neighboring gene ribonuclease, RNase A family, 1 (pancreatic) Neighboring gene eosinophil-associated, ribonuclease A family, pseudogene 1 Neighboring gene angiogenin, ribonuclease A family, member 2

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

Markers

Homology

Clone Names

  • MGC143624

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables endonuclease activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
 
enables nuclease activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables ribonuclease A activity IEA
Inferred from Electronic Annotation
more info
 
enables ribonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ribonuclease activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in defense response to Gram-positive bacterium IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in innate immune response in mucosa IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
ribonuclease 2B
Names
MR-5
eosinophil cationic-type ribonuclease 5
eosinophil-associated ribonuclease 5
eosinophil-associated, ribonuclease A family, member 5
murine ribonuclease 5
ribonuclease A f4
NP_062271.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019398.2NP_062271.2  ribonuclease 2B precursor

    See identical proteins and their annotated locations for NP_062271.2

    Status: VALIDATED

    Source sequence(s)
    AC163664
    Consensus CDS
    CCDS27039.1
    UniProtKB/Swiss-Prot
    O35292, Q8K416
    UniProtKB/TrEMBL
    A0A8C6HMV7, W0UVC5
    Related
    ENSMUSP00000075074.4, ENSMUST00000075648.4
    Conserved Domains (1) summary
    pfam00074
    Location:29152
    RnaseA; Pancreatic ribonuclease

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    51399717..51400475
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)