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EOLA2 endothelium and lymphocyte associated ASCH domain 2 [ Homo sapiens (human) ]

Gene ID: 541578, updated on 3-Mar-2026
Official Symbol
EOLA2provided by HGNC
Official Full Name
endothelium and lymphocyte associated ASCH domain 2provided by HGNC
Primary source
HGNC:HGNC:17402
See related
Ensembl:ENSG00000197021 AllianceGenome:HGNC:17402
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CXorf40B
Summary
Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]
Expression
Ubiquitous expression in adrenal (RPKM 9.8), placenta (RPKM 4.0) and 25 other tissues See more
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See EOLA2 in Genome Data Viewer
Location:
Xq28
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2025_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (149929532..149938491, complement)
RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (148191783..148206471, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (149100415..149106709, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 30017 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 30018 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 30019 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 30020 Neighboring gene long intergenic non-protein coding RNA 850 Neighboring gene MAGEA8 antisense RNA 1 Neighboring gene MAGE family member A8 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21046 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21047 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21048 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21049 Neighboring gene EOLA2 divergent transcript Neighboring gene heat shock transcription factor family, X-linked member 4 Neighboring gene NOL11 pseudogene 1

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. 130 kb of DNA sequence reveals two new genes and a regional duplication distal to the human iduronate-2-sulfate sulfatase locus. Timms KM, et al. Genome Res, 1995 Aug. PMID 8717057
  2. Molecular and phenotypic variation in patients with severe Hunter syndrome. Timms KM, et al. Hum Mol Genet, 1997 Mar. PMID 9147653
  3. The DNA sequence of the human X chromosome. Ross MT, et al. Nature, 2005 Mar 17. PMID 15772651, Free PMC Article
  4. Transcriptome analysis of human gastric cancer. Oh JH, et al. Mamm Genome, 2005 Dec. PMID 16341674
  5. Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Morgenstern M, et al. Cell Metab, 2021 Dec 7. PMID 34800366, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

Markers

Homology

Clone Names

  • FLJ16523

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in mitochondrion HTP PubMed 
Preferred Names
protein EOLA2
Names
protein CXorf40B

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013845.2 → NP_001013867.1  protein EOLA2 isoform 1

    See identical proteins and their annotated locations for NP_001013867.1

    Status: VALIDATED

    Source sequence(s)
    BC009523, BM847839, U66042
    Consensus CDS
    CCDS35426.1
    UniProtKB/Swiss-Prot
    Q96DE9
    UniProtKB/TrEMBL
    S4R3G8
    Related
    ENSP00000359434.3, ENST00000370406.8
    Conserved Domains (1) summary
    smart01022
    Location:6 → 108
    ASCH; The ASCH domain adopts a beta-barrel fold similar to that of the PUA domain

  2. NM_001437940.1 → NP_001424869.1  protein EOLA2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC244099
    UniProtKB/TrEMBL
    Q5HY62, S4R3G8
    Related
    ENSP00000417546.1, ENST00000462691.5

  3. NM_001438792.1 → NP_001425721.1  protein EOLA2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC244099
    UniProtKB/Swiss-Prot
    Q96DE9
    UniProtKB/TrEMBL
    S4R3G8
    Related
    ENSP00000359432.1, ENST00000370404.5

  4. NM_001438793.1 → NP_001425722.1  protein EOLA2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC244099
    UniProtKB/Swiss-Prot
    Q96DE9
    UniProtKB/TrEMBL
    S4R3G8
    Related
    ENSP00000554129.1, ENST00000884070.1

  5. NM_001438794.1 → NP_001425723.1  protein EOLA2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC244099
    UniProtKB/Swiss-Prot
    Q96DE9
    UniProtKB/TrEMBL
    S4R3G8
    Related
    ENSP00000474324.1, ENST00000370409.7

  6. NM_001438795.1 → NP_001425724.1  protein EOLA2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC244099
    UniProtKB/Swiss-Prot
    Q96DE9
    UniProtKB/TrEMBL
    S4R3G8
    Related
    ENSP00000554117.1, ENST00000884058.1

  7. NM_001438796.1 → NP_001425725.1  protein EOLA2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC244099
    UniProtKB/Swiss-Prot
    Q96DE9
    UniProtKB/TrEMBL
    S4R3G8
    Related
    ENSP00000554118.1, ENST00000884059.1

  8. NM_001438797.1 → NP_001425726.1  protein EOLA2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC244099
    UniProtKB/Swiss-Prot
    Q96DE9
    UniProtKB/TrEMBL
    S4R3G8
    Related
    ENSP00000554119.1, ENST00000884060.1

  9. NM_001438798.1 → NP_001425727.1  protein EOLA2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC244099
    UniProtKB/Swiss-Prot
    Q96DE9
    UniProtKB/TrEMBL
    S4R3G8
    Related
    ENSP00000554135.1, ENST00000884076.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    149929532..149938491 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024452391.2 → XP_024308159.1  protein EOLA2 isoform X2

    UniProtKB/TrEMBL
    Q5HY62, S4R3G8
    Conserved Domains (1) summary
    smart01022
    Location:6 → 108
    ASCH; The ASCH domain adopts a beta-barrel fold similar to that of the PUA domain

  2. XM_047442179.1 → XP_047298135.1  protein EOLA2 isoform X2

    UniProtKB/TrEMBL
    Q5HY62, S4R3G8

  3. XM_017029593.3 → XP_016885082.1  protein EOLA2 isoform X2

    UniProtKB/TrEMBL
    Q5HY62, S4R3G8
    Conserved Domains (1) summary
    smart01022
    Location:6 → 108
    ASCH; The ASCH domain adopts a beta-barrel fold similar to that of the PUA domain

  4. XM_017029592.3 → XP_016885081.1  protein EOLA2 isoform X2

    UniProtKB/TrEMBL
    Q5HY62, S4R3G8
    Conserved Domains (1) summary
    smart01022
    Location:6 → 108
    ASCH; The ASCH domain adopts a beta-barrel fold similar to that of the PUA domain

  5. XM_047442178.1 → XP_047298134.1  protein EOLA2 isoform X2

    UniProtKB/TrEMBL
    Q5HY62, S4R3G8

  6. XM_017029591.3 → XP_016885080.1  protein EOLA2 isoform X2

    UniProtKB/TrEMBL
    Q5HY62, S4R3G8
    Conserved Domains (1) summary
    smart01022
    Location:6 → 108
    ASCH; The ASCH domain adopts a beta-barrel fold similar to that of the PUA domain

  7. XM_047442177.1 → XP_047298133.1  protein EOLA2 isoform X2

    UniProtKB/TrEMBL
    Q5HY62, S4R3G8

  8. XM_047442174.1 → XP_047298130.1  protein EOLA2 isoform X1

    UniProtKB/Swiss-Prot
    Q96DE9
    UniProtKB/TrEMBL
    S4R3G8
    Related
    ENSP00000624056.1, ENST00000953997.1

  9. XM_017029585.3 → XP_016885074.1  protein EOLA2 isoform X1

    UniProtKB/Swiss-Prot
    Q96DE9
    UniProtKB/TrEMBL
    S4R3G8
    Conserved Domains (1) summary
    smart01022
    Location:6 → 108
    ASCH; The ASCH domain adopts a beta-barrel fold similar to that of the PUA domain

  10. XM_017029588.3 → XP_016885077.1  protein EOLA2 isoform X1

    UniProtKB/Swiss-Prot
    Q96DE9
    UniProtKB/TrEMBL
    S4R3G8
    Related
    ENSP00000554128.1, ENST00000884069.1
    Conserved Domains (1) summary
    smart01022
    Location:6 → 108
    ASCH; The ASCH domain adopts a beta-barrel fold similar to that of the PUA domain

  11. XM_017029589.2 → XP_016885078.1  protein EOLA2 isoform X1

    UniProtKB/Swiss-Prot
    Q96DE9
    UniProtKB/TrEMBL
    S4R3G8
    Related
    ENSP00000554122.1, ENST00000884063.1
    Conserved Domains (1) summary
    smart01022
    Location:6 → 108
    ASCH; The ASCH domain adopts a beta-barrel fold similar to that of the PUA domain

  12. XM_047442175.1 → XP_047298131.1  protein EOLA2 isoform X1

    UniProtKB/Swiss-Prot
    Q96DE9
    UniProtKB/TrEMBL
    S4R3G8
    Related
    ENSP00000554133.1, ENST00000884074.1

  13. XM_047442176.1 → XP_047298132.1  protein EOLA2 isoform X1

    UniProtKB/Swiss-Prot
    Q96DE9
    UniProtKB/TrEMBL
    S4R3G8
    Related
    ENSP00000554136.1, ENST00000884077.1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    148191783..148206471 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054327241.1 → XP_054183216.1  protein EOLA2 isoform X2

    UniProtKB/TrEMBL
    Q5HY62, S4R3G8

  2. XM_054327238.1 → XP_054183213.1  protein EOLA2 isoform X2

    UniProtKB/TrEMBL
    Q5HY62, S4R3G8

  3. XM_054327240.1 → XP_054183215.1  protein EOLA2 isoform X2

    UniProtKB/TrEMBL
    Q5HY62, S4R3G8

  4. XM_054327243.1 → XP_054183218.1  protein EOLA2 isoform X2

    UniProtKB/TrEMBL
    Q5HY62, S4R3G8

  5. XM_054327244.1 → XP_054183219.1  protein EOLA2 isoform X2

    UniProtKB/TrEMBL
    Q5HY62, S4R3G8

  6. XM_054327242.1 → XP_054183217.1  protein EOLA2 isoform X2

    UniProtKB/TrEMBL
    Q5HY62, S4R3G8

  7. XM_054327239.1 → XP_054183214.1  protein EOLA2 isoform X2

    UniProtKB/TrEMBL
    Q5HY62, S4R3G8

  8. XM_054327227.1 → XP_054183202.1  protein EOLA2 isoform X1

    UniProtKB/Swiss-Prot
    Q96DE9
    UniProtKB/TrEMBL
    S4R3G8

  9. XM_054327225.1 → XP_054183200.1  protein EOLA2 isoform X1

    UniProtKB/Swiss-Prot
    Q96DE9
    UniProtKB/TrEMBL
    S4R3G8

  10. XM_054327228.1 → XP_054183203.1  protein EOLA2 isoform X1

    UniProtKB/Swiss-Prot
    Q96DE9
    UniProtKB/TrEMBL
    S4R3G8

  11. XM_054327224.1 → XP_054183199.1  protein EOLA2 isoform X1

    UniProtKB/Swiss-Prot
    Q96DE9
    UniProtKB/TrEMBL
    S4R3G8

  12. XM_054327230.1 → XP_054183205.1  protein EOLA2 isoform X1

    UniProtKB/Swiss-Prot
    Q96DE9
    UniProtKB/TrEMBL
    S4R3G8

  13. XM_054327236.1 → XP_054183211.1  protein EOLA2 isoform X1

    UniProtKB/Swiss-Prot
    Q96DE9
    UniProtKB/TrEMBL
    S4R3G8

  14. XM_054327235.1 → XP_054183210.1  protein EOLA2 isoform X1

    UniProtKB/Swiss-Prot
    Q96DE9
    UniProtKB/TrEMBL
    S4R3G8

  15. XM_054327232.1 → XP_054183207.1  protein EOLA2 isoform X1

    UniProtKB/Swiss-Prot
    Q96DE9
    UniProtKB/TrEMBL
    S4R3G8

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001039761.2: Suppressed sequence

    Description
    NM_001039761.2: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96DE9.1 GenPept UniProtKB/Swiss-Prot:Q96DE9

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