Format

Send to:

Choose Destination

C21orf91 chromosome 21 open reading frame 91 [ Homo sapiens (human) ]

Gene ID: 54149, updated on 24-Nov-2020

Summary

Official Symbol
C21orf91provided by HGNC
Official Full Name
chromosome 21 open reading frame 91provided by HGNC
Primary source
HGNC:HGNC:16459
See related
Ensembl:ENSG00000154642
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EURL; YG81; CSSG1; C21orf14; C21orf38
Expression
Ubiquitous expression in testis (RPKM 14.4), lymph node (RPKM 10.5) and 24 other tissues See more
Orthologs

Genomic context

See C21orf91 in Genome Data Viewer
Location:
21q21.1
Exon count:
5
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 21 NC_000021.9 (17788974..17819356, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (19161284..19191703, complement)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene CXADR Ig-like cell adhesion molecule Neighboring gene BTG3 antisense RNA 1 Neighboring gene BTG anti-proliferation factor 3 Neighboring gene uncharacterized LOC105372741 Neighboring gene C21orf91 overlapping transcript 1 Neighboring gene CHODL antisense RNA 1 Neighboring gene chondrolectin Neighboring gene ribosomal protein L37 pseudogene 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp781D1223

Gene Ontology Provided by GOA

Process Evidence Code Pubs
cerebral cortex neuron differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of dendritic spine development ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
protein EURL homolog
Names
cold sore susceptibility gene 1
early undifferentiated retina and lens

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100420.2NP_001093890.1  protein EURL homolog isoform 1

    See identical proteins and their annotated locations for NP_001093890.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AK023825, AL109761, BF739854, CR749496, DA215855, DB066982
    Consensus CDS
    CCDS42907.1
    UniProtKB/Swiss-Prot
    Q9NYK6
    UniProtKB/TrEMBL
    Q68DA1
    Related
    ENSP00000284881.4, ENST00000284881.9
    Conserved Domains (1) summary
    pfam06937
    Location:1291
    EURL; EURL protein
  2. NM_001100421.2NP_001093891.1  protein EURL homolog isoform 3

    See identical proteins and their annotated locations for NP_001093891.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an exon in the 3' coding region, compared to variant 1. The resulting isoform (3) is C-terminal truncated, compared to isoform 1.
    Source sequence(s)
    AF239726, AL109761, BF739854, CR749496, DA215855
    Consensus CDS
    CCDS42909.1
    UniProtKB/Swiss-Prot
    Q9NYK6
    UniProtKB/TrEMBL
    Q68DA1
    Related
    ENSP00000383403.3, ENST00000400558.7
    Conserved Domains (1) summary
    pfam06937
    Location:1221
    EURL; EURL protein
  3. NM_017447.4NP_059143.3  protein EURL homolog isoform 2

    See identical proteins and their annotated locations for NP_059143.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate in-frame splice site in the 3' coding region, compared to variant 1. The resulting isoform (2) lacks an internal aa, compared to isoform 1.
    Source sequence(s)
    AL109761, BC015468, BF739854, CR749496, DA215855
    Consensus CDS
    CCDS42908.1
    UniProtKB/Swiss-Prot
    Q9NYK6
    UniProtKB/TrEMBL
    Q68DA1
    Related
    ENSP00000383404.3, ENST00000400559.7
    Conserved Domains (1) summary
    pfam06937
    Location:1290
    EURL; EURL protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p13 Primary Assembly

    Range
    17788974..17819356 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center