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parla presenilin associated, rhomboid-like a [ Danio rerio (zebrafish) ]

Gene ID: 541485, updated on 3-Oct-2019

Summary

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Official Symbol
parlaprovided by ZNC
Official Full Name
presenilin associated, rhomboid-like aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-050327-8
See related
Ensembl:ENSDARG00000039310
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Cyprinidae; Danio
Also known as
parl; zgc:112986

Genomic context

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See parla in Genome Data Viewer
Location:
chromosome: 2
Exon count:
11
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (5543894..5561026, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (5631910..5649141, complement)
103 previous assembly Zv9 (GCF_000002035.4) 2 NC_007113.5 (5186285..5203413, complement)

Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene claudin 15-like a Neighboring gene cytokine receptor family member B16 Neighboring gene uncharacterized LOC110437956 Neighboring gene Mab-21 domain containing 2 Neighboring gene fibroblast growth factor 12a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Zebrafish Parla- and Parlb-deficiency affects dopaminergic neuron patterning and embryonic survival. Noble S, et al. J Neurochem, 2012 Jul. PMID 22506991
  2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. This study demonistrated that Zebrafish Parla- and Parlb-deficiency affects dopaminergic neuron patterning and embryonic survival.
    Title: Zebrafish Parla- and Parlb-deficiency affects dopaminergic neuron patterning and embryonic survival.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
peptidase activity IEA
Inferred from Electronic Annotation
more info
  
serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
serine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
proteolysis IEA
Inferred from Electronic Annotation
more info
  
regulation of mitochondrion organization IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
  
membrane IEA
Inferred from Electronic Annotation
more info
  
mitochondrial inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
presenilins-associated rhomboid-like protein, mitochondrial
Names
parlb
NP_001014320.1
XP_009295364.1
XP_009295371.1
XP_009295376.1
XP_021335847.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001014298.1 → NP_001014320.1  presenilins-associated rhomboid-like protein, mitochondrial precursor

    See identical proteins and their annotated locations for NP_001014320.1

    Status: PROVISIONAL

    Source sequence(s)
    BC091865
    UniProtKB/Swiss-Prot
    Q58EK4
    UniProtKB/TrEMBL
    B2GQL1
    Related
    ENSDARP00000057438.4, ENSDART00000057439.5
    Conserved Domains (1) summary
    pfam01694
    Location:210 → 347
    Rhomboid; Rhomboid family

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007113.7 Reference GRCz11 Primary Assembly

    Range
    5543894..5561026 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021480172.1 → XP_021335847.1  presenilins-associated rhomboid-like protein, mitochondrial isoform X1

    Conserved Domains (1) summary
    cl21536
    Location:210 → 305
    Rhomboid; Rhomboid family

  2. XM_009297096.3 → XP_009295371.1  presenilins-associated rhomboid-like protein, mitochondrial isoform X3

    See identical proteins and their annotated locations for XP_009295371.1

    Conserved Domains (1) summary
    pfam01694
    Location:22 → 159
    Rhomboid; Rhomboid family

  3. XM_009297101.3 → XP_009295376.1  presenilins-associated rhomboid-like protein, mitochondrial isoform X3

    See identical proteins and their annotated locations for XP_009295376.1

    Conserved Domains (1) summary
    pfam01694
    Location:22 → 159
    Rhomboid; Rhomboid family

  4. XM_009297089.2 → XP_009295364.1  presenilins-associated rhomboid-like protein, mitochondrial isoform X2

    Conserved Domains (1) summary
    cl21536
    Location:210 → 277
    Rhomboid; Rhomboid family

RNA

  1. XR_002459727.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q58EK4.1 GenPept UniProtKB/Swiss-Prot:Q58EK4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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