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MRPL39 mitochondrial ribosomal protein L39 [ Homo sapiens (human) ]

Gene ID: 54148, updated on 29-Jun-2024

Summary

Official Symbol
MRPL39provided by HGNC
Official Full Name
mitochondrial ribosomal protein L39provided by HGNC
Primary source
HGNC:HGNC:14027
See related
Ensembl:ENSG00000154719 MIM:611845; AllianceGenome:HGNC:14027
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
L5mt; mL39; L39mt; MRPL5; RPML5; MRP-L5; PRED22; PRED66; COXPD59; MSTP003; C21orf92
Summary
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Two transcript variants encoding distinct isoforms have been described. A pseudogene corresponding to this gene is found on chromosome 5q. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 23.0), adrenal (RPKM 13.9) and 25 other tissues See more
Orthologs
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Genomic context

See MRPL39 in Genome Data Viewer
Location:
21q21.3
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 21 NC_000021.9 (25585656..25607859, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 21 NC_060945.1 (23943220..23965426, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (26957968..26979793, complement)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene MIR155 host gene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13229 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18310 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18311 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18312 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18313 Neighboring gene microRNA 155 Neighboring gene long intergenic non-protein coding RNA 515 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18314 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13230 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18315 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13231 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:27012080-27012580 Neighboring gene uncharacterized LOC124905001 Neighboring gene RNA guanylyltransferase and 5'-phosphatase pseudogene 1 Neighboring gene junctional adhesion molecule 2 Neighboring gene ReSE screen-validated silencer GRCh37_chr21:27054065-27054224 Neighboring gene ferredoxin 1 pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
large ribosomal subunit protein mL39
Names
39S ribosomal protein L39, mitochondrial
39S ribosomal protein L5, mitochondrial
mitochondrial large ribosomal subunit protein mL39

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017446.4NP_059142.3  large ribosomal subunit protein mL39 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the predominant isoform (a).
    Source sequence(s)
    AP000223
    Consensus CDS
    CCDS13573.1
    UniProtKB/Swiss-Prot
    C9JYA5, Q32Q74, Q5QTR3, Q96Q65, Q9BSQ7, Q9BZV6, Q9NX44, Q9NYK5
    UniProtKB/TrEMBL
    C9JG87
    Related
    ENSP00000284967.7, ENST00000352957.9
    Conserved Domains (1) summary
    PLN02908
    Location:44303
    PLN02908; threonyl-tRNA synthetase
  2. NM_080794.4NP_542984.3  large ribosomal subunit protein mL39 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2), also known as MRP-L5V1 or the heart-specific transcript variant, includes an alternate segment, when compared to variant 1, that causes a frameshift. The encoded isoform (b) has a distinct and longer C-terminus, compared to isoform a.
    Source sequence(s)
    AP000223
    Consensus CDS
    CCDS33522.1
    UniProtKB/TrEMBL
    C9JG87
    Related
    ENSP00000305682.7, ENST00000307301.11
    Conserved Domains (1) summary
    PLN02908
    Location:44303
    PLN02908; threonyl-tRNA synthetase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p14 Primary Assembly

    Range
    25585656..25607859 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011529651.3XP_011527953.1  large ribosomal subunit protein mL39 isoform X1

    UniProtKB/TrEMBL
    C9JG87
    Conserved Domains (1) summary
    cd01667
    Location:3488
    TGS_ThrRS_N; TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and ...
  2. XM_006724026.5XP_006724089.1  large ribosomal subunit protein mL39 isoform X2

    UniProtKB/TrEMBL
    C9JG87
    Conserved Domains (1) summary
    PLN02908
    Location:44303
    PLN02908; threonyl-tRNA synthetase

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060945.1 Alternate T2T-CHM13v2.0

    Range
    23943220..23965426 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054324690.1XP_054180665.1  large ribosomal subunit protein mL39 isoform X1

    UniProtKB/TrEMBL
    C9JG87
  2. XM_054324691.1XP_054180666.1  large ribosomal subunit protein mL39 isoform X2

    UniProtKB/TrEMBL
    C9JG87