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MRPL39 mitochondrial ribosomal protein L39 [ Homo sapiens (human) ]

Gene ID: 54148, updated on 20-Dec-2019

Summary

Official Symbol
MRPL39provided by HGNC
Official Full Name
mitochondrial ribosomal protein L39provided by HGNC
Primary source
HGNC:HGNC:14027
See related
Ensembl:ENSG00000154719 MIM:611845
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
L39mt; MRPL5; RPML5; MRP-L5; PRED22; PRED66; MSTP003; C21orf92
Summary
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Two transcript variants encoding distinct isoforms have been described. A pseudogene corresponding to this gene is found on chromosome 5q. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 23.0), adrenal (RPKM 13.9) and 25 other tissues See more
Orthologs

Genomic context

See MRPL39 in Genome Data Viewer
Location:
21q21.3
Exon count:
12
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 21 NC_000021.9 (25585656..25607858, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (26957968..26979801, complement)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene MIR155 host gene Neighboring gene microRNA 155 Neighboring gene long intergenic non-protein coding RNA 515 Neighboring gene junctional adhesion molecule 2 Neighboring gene RNA guanylyltransferase and 5'-phosphatase pseudogene 1 Neighboring gene ferredoxin 1 pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC3400, FLJ20451, MGC104174

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
mitochondrial translational elongation TAS
Traceable Author Statement
more info
 
mitochondrial translational termination TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
mitochondrial inner membrane TAS
Traceable Author Statement
more info
 
mitochondrial large ribosomal subunit IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial ribosome NAS
Non-traceable Author Statement
more info
PubMed 
mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
39S ribosomal protein L39, mitochondrial
Names
39S ribosomal protein L5, mitochondrial
L5mt
MRP-L39
mitochondrial large ribosomal subunit protein mL39

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017446.4NP_059142.3  39S ribosomal protein L39, mitochondrial isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the predominant isoform (a).
    Source sequence(s)
    AP000223
    Consensus CDS
    CCDS13573.1
    Related
    ENSP00000284967.6, ENST00000352957.8
  2. NM_080794.4NP_542984.3  39S ribosomal protein L39, mitochondrial isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2), also known as MRP-L5V1 or the heart-specific transcript variant, includes an alternate segment, when compared to variant 1, that causes a frameshift. The encoded isoform (b) has a distinct and longer C-terminus, compared to isoform a.
    Source sequence(s)
    AP000223
    Consensus CDS
    CCDS33522.1
    Related
    ENSP00000305682.7, ENST00000307301.11

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p13 Primary Assembly

    Range
    25585656..25607858 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011529651.2XP_011527953.1  39S ribosomal protein L39, mitochondrial isoform X1

    Conserved Domains (1) summary
    cd01667
    Location:3488
    TGS_ThrRS_N; TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and ...
  2. XM_006724026.4XP_006724089.1  39S ribosomal protein L39, mitochondrial isoform X2

    UniProtKB/Swiss-Prot
    Q9NYK5
    Conserved Domains (1) summary
    cd01667
    Location:76130
    TGS_ThrRS_N; TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and ...
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