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acss1 acyl-CoA synthetase short chain family member 1 [ Danio rerio (zebrafish) ]

Gene ID: 541435, updated on 9-Sep-2025
Official Symbol
acss1provided by ZNC
Official Full Name
acyl-CoA synthetase short chain family member 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-050320-139
See related
Ensembl:ENSDARG00000044142 AllianceGenome:ZFIN:ZDB-GENE-050320-139
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
cb395; sb:cb395; wu:fa05a10; wu:fc49f03; wu:fi28d10; zgc:113194; zgc:158738
Summary
Predicted to enable acetate-CoA ligase activity. Predicted to be involved in acetyl-CoA biosynthetic process. Predicted to act upstream of or within acetyl-CoA biosynthetic process from acetate and lipid metabolic process. Predicted to be active in mitochondrion. Is expressed in several structures, including blood; central nervous system; mesoderm; neural plate; and notochord. Orthologous to human ACSS1 (acyl-CoA synthetase short chain family member 1). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs
human mouse all
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See acss1 in Genome Data Viewer
Location:
chromosome: 17
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 17 NC_133192.1 (27244788..27264880)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 17 NC_007128.7 (25833947..25853915)

Chromosome 17 - NC_133192.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC141378471 Neighboring gene hedgehog acyltransferase Neighboring gene uncharacterized LOC141378572 Neighboring gene WAPL cohesin release factor a Neighboring gene glutamate receptor, ionotropic, delta 1a Neighboring gene uncharacterized LOC141378573

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. A novel Acetyl-CoA synthetase short-chain subfamily member 1 (Acss1) gene indicates a dynamic history of paralogue retention and loss in vertebrates. Castro LF, et al. Gene, 2012 Apr 15. PMID 22313524
  2. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Markers

Homology

Clone Names

  • MGC158738, MGC174587

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables AMP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables CoA-ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables acetate-CoA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables acetate-CoA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables acid-thiol ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in acetyl-CoA biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within acetyl-CoA biosynthetic process from acetate IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
acetyl-coenzyme A synthetase 2-like, mitochondrial
Names
ACSS1A
NP_001074125.3

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080656.3 → NP_001074125.3  acetyl-coenzyme A synthetase 2-like, mitochondrial

    Status: VALIDATED

    Source sequence(s)
    AL929023, BX000364, BX511070
    UniProtKB/TrEMBL
    A0A8M1ND09, F1QYS7
    Related
    ENSDARP00000044327.6, ENSDART00000044328.9
    Conserved Domains (2) summary
    cd05966
    Location:66 → 672
    ACS; Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme)
    TIGR02188
    Location:62 → 682
    Ac_CoA_lig_AcsA; acetate--CoA ligase

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133192.1 Reference GRCz12tu Primary Assembly

    Range
    27244788..27264880
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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