xrcc3 X-ray repair complementing 3 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: xrcc3provided by ZNC
Official Full Name: X-ray repair complementing 3provided by ZNC
Primary source: ZFIN:ZDB-GENE-050320-116
See related: Ensembl:ENSDARG00000017928 AllianceGenome:ZFIN:ZDB-GENE-050320-116
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: im:7142103; zgc:101608; si:dkey-11b8.1
Summary: Predicted to enable ATP binding activity; ATP-dependent DNA damage sensor activity; and DNA binding activity. Predicted to contribute to four-way junction DNA binding activity. Predicted to be involved in DNA metabolic process. Predicted to act upstream of or within DNA repair. Predicted to be part of Rad51C-XRCC3 complex. Predicted to be active in replication fork. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); central nervous system cancer (multiple); familial melanoma; multiple myeloma; and pancreatic cancer. Orthologous to human XRCC3 (X-ray repair cross complementing 3). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs: all
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Genomic context

Location:: chromosome: 20

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2025_04	current	GRCz12tu (GCF_049306965.1)	20	NC_133195.1 (23441367..23446006, complement)
RS_2024_08	previous assembly	GRCz11 (GCF_000002035.6)	20	NC_007131.7 (20896690..20901329, complement)

Chromosome 20 - NC_133195.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP-dependent DNA damage sensor activity	IEA Inferred from Electronic Annotation more info
enables DNA binding	IEA Inferred from Electronic Annotation more info
contributes_to four-way junction DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in double-strand break repair via synthesis-dependent strand annealing	IBA Inferred from Biological aspect of Ancestor more info
involved_in resolution of mitotic recombination intermediates	IBA Inferred from Biological aspect of Ancestor more info
involved_in t-circle formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in telomere maintenance via recombination	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of Rad51C-XRCC3 complex	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
is_active_in replication fork	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: DNA repair protein XRCC3

Names: X-ray repair complementing defective repair in Chinese hamster cells 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001013541.1 → NP_001013559.1 DNA repair protein XRCC3

See identical proteins and their annotated locations for NP_001013559.1

Status: PROVISIONAL

Source sequence(s)

BC090820

UniProtKB/TrEMBL

A0A8M1N4R6, Q5BL30

Related

ENSDARP00000004619.5, ENSDART00000010564.8

Conserved Domains (2) summary

cd01123
Location:82 → 340

Rad51_DMC1_radA; Rad51_DMC1_radA,B. This group of recombinases includes the eukaryotic proteins RAD51, RAD55/57 and the meiosis-specific protein DMC1, and the archaeal proteins radA and radB. They are closely related to the bacterial RecA group. Rad51 proteins catalyze a ...

pfam08423
Location:81 → 339

Rad51; Rad51