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Spag5 sperm associated antigen 5 [ Mus musculus (house mouse) ]

Gene ID: 54141, updated on 26-Sep-2022

Summary

Official Symbol
Spag5provided by MGI
Official Full Name
sperm associated antigen 5provided by MGI
Primary source
MGI:MGI:1927470
See related
Ensembl:ENSMUSG00000002055 AllianceGenome:MGI:1927470
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
S17; MAP126; Deepest; Mastrin; D11Bhm180e
Summary
Predicted to enable microtubule binding activity. Acts upstream of or within establishment of spindle orientation. Located in ciliary basal body; ciliary rootlet; and mitotic spindle. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Orthologous to human SPAG5 (sperm associated antigen 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 16.1), testis adult (RPKM 15.3) and 17 other tissues See more
Orthologs
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Genomic context

See Spag5 in Genome Data Viewer
Location:
11 B5; 11 46.74 cM
Exon count:
24
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (78192412..78213283)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (78301470..78322457)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene bridge-like lipid transfer protein family member 2 Neighboring gene predicted gene 3948 Neighboring gene ribosomal protein S6 kinase related Neighboring gene aldolase C, fructose-bisphosphate Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class S

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables microtubule binding ISO
Inferred from Sequence Orthology
more info
PubMed 
Component Evidence Code Pubs
located_in centriolar satellite ISO
Inferred from Sequence Orthology
more info
 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
 
located_in ciliary basal body IDA
Inferred from Direct Assay
more info
PubMed 
located_in ciliary rootlet IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in kinetochore ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
 
located_in microtubule plus-end ISO
Inferred from Sequence Orthology
more info
 
located_in mitotic spindle IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitotic spindle ISO
Inferred from Sequence Orthology
more info
 
located_in mitotic spindle pole ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
 
located_in spindle ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
sperm-associated antigen 5
Names
astrin
microtubule-associated protein
mitotic spindle-associated protein p126

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017407.3NP_059103.1  sperm-associated antigen 5

    See identical proteins and their annotated locations for NP_059103.1

    Status: VALIDATED

    Source sequence(s)
    AL591070
    Consensus CDS
    CCDS25098.1
    UniProtKB/Swiss-Prot
    Q7TME2, Q8CH61
    Related
    ENSMUSP00000045286.4, ENSMUST00000045026.4
    Conserved Domains (1) summary
    COG1196
    Location:5241144
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

RNA

  1. NR_156178.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL591070

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    78192412..78213283
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036156853.1XP_036012746.1  sperm-associated antigen 5 isoform X1

    Conserved Domains (2) summary
    COG1196
    Location:1568
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:58313
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

RNA

  1. XR_001780027.2 RNA Sequence

  2. XR_001780026.2 RNA Sequence

  3. XR_004936991.1 RNA Sequence

  4. XR_004936992.1 RNA Sequence

  5. XR_003949480.2 RNA Sequence