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Avpr1a arginine vasopressin receptor 1A [ Mus musculus (house mouse) ]

Gene ID: 54140, updated on 22-Jan-2023

Summary

Official Symbol
Avpr1aprovided by MGI
Official Full Name
arginine vasopressin receptor 1Aprovided by MGI
Primary source
MGI:MGI:1859216
See related
Ensembl:ENSMUSG00000020123 AllianceGenome:MGI:1859216
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
V1a; AVPR; V1aR; Avpr1
Summary
This gene encodes a receptor for arginine vasopressin, a neurohypophyseal hormone involved in diuresis inhibition, smooth muscle contraction, liver glycogenolysis stimulation and regulation of adrenocorticotropic hormone release from the pituitary. This receptor represents one of three G protein-coupled arginine vasopressin receptors which functions through a phosphotidylinositol-calcium second messenger system in vascular and hepatic tissues [provided by RefSeq, Jul 2008]
Expression
Biased expression in liver adult (RPKM 15.9), bladder adult (RPKM 11.1) and 13 other tissues See more
Orthologs
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Genomic context

See Avpr1a in Genome Data Viewer
Location:
10; 10 D2
Exon count:
2
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (122284404..122289358)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (122448499..122453453)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40790 Neighboring gene predicted gene, 36041 Neighboring gene predicted gene, 40791 Neighboring gene non-coding RNA suppressor of Stat1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (9)  1 citation
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (3) 

Pathways from PubChem

General gene information

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables V1A vasopressin receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables peptide binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables peptide hormone binding ISO
Inferred from Sequence Orthology
more info
 
enables vasopressin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables vasopressin receptor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in calcium-mediated signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to hormone stimulus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in grooming behavior ISO
Inferred from Sequence Orthology
more info
 
involved_in maternal aggressive behavior ISO
Inferred from Sequence Orthology
more info
 
involved_in maternal behavior ISO
Inferred from Sequence Orthology
more info
 
involved_in multicellular organism aging IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in multicellular organism aging IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of female receptivity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transmission of nerve impulse ISO
Inferred from Sequence Orthology
more info
 
involved_in penile erection ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of blood pressure ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cellular pH reduction ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of glutamate secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of heart rate ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of prostaglandin biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of renal sodium excretion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of systemic arterial blood pressure ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of vasoconstriction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of vasoconstriction ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of blood pressure IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of systemic arterial blood pressure by vasopressin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within regulation of systemic arterial blood pressure by vasopressin IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in response to inorganic substance ISO
Inferred from Sequence Orthology
more info
 
involved_in response to organic substance ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in social behavior ISO
Inferred from Sequence Orthology
more info
 
involved_in sperm ejaculation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in endocytic vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in endosome ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
vasopressin V1a receptor
Names
AVPR V1a
V1a arginine vasopressin receptor
antidiuretic hormone receptor 1a
vascular/hepatic-type arginine vasopressin receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016847.2NP_058543.2  vasopressin V1a receptor

    See identical proteins and their annotated locations for NP_058543.2

    Status: REVIEWED

    Source sequence(s)
    D49730
    Consensus CDS
    CCDS24215.1
    UniProtKB/Swiss-Prot
    Q62463, Q9QYH2
    UniProtKB/TrEMBL
    A0A8C6ICT3, Q3U1H9
    Related
    ENSMUSP00000020323.6, ENSMUST00000020323.7
    Conserved Domains (3) summary
    pfam00001
    Location:68353
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    pfam08983
    Location:377423
    DUF1856; Domain of unknown function (DUF1856)
    cl21561
    Location:62259
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    122284404..122289358
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)