sptssa serine palmitoyltransferase, small subunit A [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: sptssaprovided by ZNC
Official Full Name: serine palmitoyltransferase, small subunit Aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-050320-26
See related: Ensembl:ENSDARG00000071203 AllianceGenome:ZFIN:ZDB-GENE-050320-26
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: wu:fb60h11; zgc:112487
Summary: Predicted to contribute to serine C-palmitoyltransferase activity. Predicted to be involved in ceramide biosynthetic process. Predicted to act upstream of or within sphingolipid metabolic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be part of serine palmitoyltransferase complex. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 90A and hereditary spastic paraplegia 90B. Orthologous to human SPTSSA (serine palmitoyltransferase small subunit A). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs: all
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Genomic context

Location:: chromosome: 17

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2025_04	current	GRCz12tu (GCF_049306965.1)	17	NC_133192.1 (11127348..11133181, complement)
RS_2024_08	previous assembly	GRCz11 (GCF_000002035.6)	17	NC_007128.7 (9944495..9950328, complement)

Chromosome 17 - NC_133192.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fd21g02.x1 (e-PCR)
- UniSTS:204293

fb60h11.y1 (e-PCR)
- UniSTS:190863

AI497507 (e-PCR)
- UniSTS:206334

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
contributes_to serine C-palmitoyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to serine C-palmitoyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in ceramide biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within sphingolipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in sphingolipid metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
part_of serine palmitoyltransferase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of serine palmitoyltransferase complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: serine palmitoyltransferase small subunit A

Names: small subunit of serine palmitoyltransferase A; ssSPTa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.