ccnh cyclin H [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ccnhprovided by ZNC
Official Full Name: cyclin Hprovided by ZNC
Primary source: ZFIN:ZDB-GENE-050320-13
See related: Ensembl:ENSDARG00000007657 AllianceGenome:ZFIN:ZDB-GENE-050320-13
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:114132
Summary: Predicted to enable cyclin-dependent protein serine/threonine kinase regulator activity. Predicted to be involved in phosphorylation of RNA polymerase II C-terminal domain and regulation of cyclin-dependent protein serine/threonine kinase activity. Predicted to act upstream of or within transcription, DNA-templated. Predicted to be part of transcription factor TFIIK complex. Predicted to be active in nucleus. Is expressed in several structures, including immature eye; liver; nervous system; neural tube; and pleuroperitoneal region. Orthologous to human CCNH (cyclin H). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 5

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (47963938..47975440, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	5	NC_007116.6 (47312429..47323954, complement)
103	previous assembly	Zv9 (GCF_000002035.4)	5	NC_007116.5 (49746728..49758231, complement)

Chromosome 5 - NC_007116.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cyclin H is implicated in the regulation of the transcriptional machinery during midblastula transition and is therefore an essential gene in early zebrafish larval development.
Title: Developmental expression of cyclin H and Cdk7 in zebrafish: the essential role of cyclin H during early embryo development.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables cyclin-dependent protein serine/threonine kinase regulator activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables cyclin-dependent protein serine/threonine kinase regulator activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of cyclin-dependent protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info	PubMed
part_of transcription factor TFIIK complex	IBA Inferred from Biological aspect of Ancestor more info	PubMed
part_of transcription factor TFIIK complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cyclin-H

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001013453.1 → NP_001013471.1 cyclin-H

See identical proteins and their annotated locations for NP_001013471.1

Status: PROVISIONAL

Source sequence(s)

BC091559

UniProtKB/TrEMBL

Q5BJA4

Related

ENSDARP00000004735.4, ENSDART00000007057.5

Conserved Domains (3) summary

TIGR00569
Location:2 → 302

ccl1; cyclin ccl1

smart00385
Location:62 → 152

CYCLIN; domain present in cyclins, TFIIB and Retinoblastoma

pfam16899
Location:162 → 262

Cyclin_C_2; Cyclin C-terminal domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007116.7 Reference GRCz11 Primary Assembly

Range

47963938..47975440 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005165512.4 → XP_005165569.1 cyclin-H isoform X2

UniProtKB/TrEMBL

A0A8M2BCT1, A2BGI0

Conserved Domains (3) summary

TIGR00569
Location:2 → 302

ccl1; cyclin ccl1

smart00385
Location:62 → 152

CYCLIN; domain present in cyclins, TFIIB and Retinoblastoma

pfam16899
Location:162 → 262

Cyclin_C_2; Cyclin C-terminal domain
XM_021476140.1 → XP_021331815.1 cyclin-H isoform X1

UniProtKB/TrEMBL

A0A8M9QDW3

Conserved Domains (1) summary

cl28538
Location:14 → 314

CCL1; Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, cyclin H subunit [Cell division and chromosome partitioning / Transcription / DNA replication, recombination, and repair]