ccnh cyclin H [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ccnhprovided by ZNC
Official Full Name: cyclin Hprovided by ZNC
Primary source: ZFIN:ZDB-GENE-050320-13
See related: Ensembl:ENSDARG00000007657 AllianceGenome:ZFIN:ZDB-GENE-050320-13
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:114132
Summary: Predicted to enable cyclin-dependent protein serine/threonine kinase regulator activity. Predicted to be involved in transcription initiation at RNA polymerase II promoter. Predicted to act upstream of or within DNA-templated transcription and regulation of transcription by RNA polymerase II. Predicted to be part of transcription factor TFIIK complex. Predicted to be active in nucleus. Is expressed in several structures, including immature eye; liver; nervous system; neural tube; and pleuroperitoneal region. Orthologous to human CCNH (cyclin H). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 5

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2025_04	current	GRCz12tu (GCF_049306965.1)	5	NC_133180.1 (52019818..52031318, complement)
RS_2024_08	previous assembly	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (47963940..47975440, complement)

Chromosome 5 - NC_133180.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cyclin H is implicated in the regulation of the transcriptional machinery during midblastula transition and is therefore an essential gene in early zebrafish larval development.
Title: Developmental expression of cyclin H and Cdk7 in zebrafish: the essential role of cyclin H during early embryo development.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables cyclin-dependent protein serine/threonine kinase regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables cyclin-dependent protein serine/threonine kinase regulator activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in transcription initiation at RNA polymerase II promoter	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of transcription factor TFIIK complex	IBA Inferred from Biological aspect of Ancestor more info
part_of transcription factor TFIIK complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cyclin-H

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001013453.1 → NP_001013471.1 cyclin-H

See identical proteins and their annotated locations for NP_001013471.1

Status: PROVISIONAL

Source sequence(s)

BC091559

UniProtKB/TrEMBL

Q5BJA4

Related

ENSDARP00000004735.4, ENSDART00000007057.5

Conserved Domains (3) summary

TIGR00569
Location:2 → 302

ccl1; cyclin ccl1

smart00385
Location:62 → 152

CYCLIN; domain present in cyclins, TFIIB and Retinoblastoma

pfam16899
Location:162 → 262

Cyclin_C_2; Cyclin C-terminal domain

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

NC_133180.1 Reference GRCz12tu Primary Assembly

Range

52019818..52031318 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_073950320.1 → XP_073806421.1 cyclin-H isoform X2

UniProtKB/TrEMBL

A0A8M2BCT1, A2BGI0
XM_005165512.6 → XP_005165569.1 cyclin-H isoform X2

UniProtKB/TrEMBL

A0A8M2BCT1, A2BGI0

Conserved Domains (3) summary

TIGR00569
Location:2 → 302

ccl1; cyclin ccl1

smart00385
Location:62 → 152

CYCLIN; domain present in cyclins, TFIIB and Retinoblastoma

pfam16899
Location:162 → 262

Cyclin_C_2; Cyclin C-terminal domain
XM_073950319.1 → XP_073806420.1 cyclin-H isoform X1