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Irf7 interferon regulatory factor 7 [ Mus musculus (house mouse) ]

Gene ID: 54123, updated on 17-Jul-2024

Summary

Official Symbol
Irf7provided by MGI
Official Full Name
interferon regulatory factor 7provided by MGI
Primary source
MGI:MGI:1859212
See related
Ensembl:ENSMUSG00000025498 AllianceGenome:MGI:1859212
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables DNA-binding transcription factor activity, RNA polymerase II-specific and cis-regulatory region sequence-specific DNA binding activity. Involved in defense response to other organism; positive regulation of transcription, DNA-templated; and regulation of toll-like receptor signaling pathway. Acts upstream of or within immunoglobulin mediated immune response; positive regulation of type I interferon production; and positive regulation of type I interferon-mediated signaling pathway. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleus. Is expressed in apical ectodermal ridge; embryo; liver; and ureter. Human ortholog(s) of this gene implicated in immunodeficiency 39. Orthologous to human IRF7 (interferon regulatory factor 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in duodenum adult (RPKM 108.3), small intestine adult (RPKM 93.2) and 18 other tissues See more
Orthologs
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Genomic context

See Irf7 in Genome Data Viewer
Location:
7 F5; 7 86.57 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (140843096..140846412, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (141263183..141266499, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2854 Neighboring gene microRNA 210 Neighboring gene STARR-positive B cell enhancer ABC_E11376 Neighboring gene predicted gene, 51460 Neighboring gene PHD and ring finger domains 1 Neighboring gene cadherin-related family member 5 Neighboring gene secretin

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (2) 
  • Endonuclease-mediated (2) 
  • Targeted (2)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in cytoplasmic pattern recognition receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in defense response to virus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in defense response to virus ISO
Inferred from Sequence Orthology
more info
 
involved_in immune system process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within immunoglobulin mediated immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interferon-alpha production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interferon-alpha production TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of interferon-beta production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interferon-beta production TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of type I interferon production IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of type I interferon production IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of type I interferon production ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of type I interferon-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of MyD88-dependent toll-like receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of MyD88-independent toll-like receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of adaptive immune response ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of gene expression IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of innate immune response TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within type I interferon production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in type I interferon-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of chromatin ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
interferon regulatory factor 7
Names
IRF-7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252600.1NP_001239529.1  interferon regulatory factor 7 isoform 2

    See identical proteins and their annotated locations for NP_001239529.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 3' coding region, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1.
    Source sequence(s)
    AK152403, BQ033099, BY155234
    Consensus CDS
    CCDS57595.1
    UniProtKB/TrEMBL
    Q3TW14
    Related
    ENSMUSP00000095565.3, ENSMUST00000097952.9
    Conserved Domains (2) summary
    pfam00605
    Location:11124
    IRF; Interferon regulatory factor transcription factor
    pfam10401
    Location:212389
    IRF-3; Interferon-regulatory factor 3
  2. NM_001252601.1NP_001239530.1  interferon regulatory factor 7 isoform 3

    See identical proteins and their annotated locations for NP_001239530.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses a different splice site in the coding region, compared to variant 1. The resulting protein (isoform 3) is shorter when it is compared to isoform 1.
    Source sequence(s)
    AK002830, AK151470, BQ033099, BY155234, DT923384
    Consensus CDS
    CCDS57594.1
    UniProtKB/TrEMBL
    D3Z4U9
    Related
    ENSMUSP00000101644.2, ENSMUST00000106023.8
    Conserved Domains (2) summary
    pfam00605
    Location:11124
    IRF; Interferon regulatory factor transcription factor
    pfam10401
    Location:211388
    IRF-3; Interferon-regulatory factor 3
  3. NM_016850.3NP_058546.1  interferon regulatory factor 7 isoform 1

    See identical proteins and their annotated locations for NP_058546.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and it encodes the longest protein (isoform 1).
    Source sequence(s)
    AK079685, BQ033099, BY155234
    Consensus CDS
    CCDS22005.1
    UniProtKB/Swiss-Prot
    P70434
    UniProtKB/TrEMBL
    Q542T3
    Related
    ENSMUSP00000026571.5, ENSMUST00000026571.11
    Conserved Domains (2) summary
    pfam00605
    Location:11124
    IRF; Interferon regulatory factor transcription factor
    pfam10401
    Location:243420
    IRF-3; Interferon-regulatory factor 3

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    140843096..140846412 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006536214.1XP_006536277.1  interferon regulatory factor 7 isoform X1

    Conserved Domains (2) summary
    pfam00605
    Location:12124
    IRF; Interferon regulatory factor transcription factor
    pfam10401
    Location:180357
    IRF-3; Interferon-regulatory factor 3