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GPR88 G protein-coupled receptor 88 [ Homo sapiens (human) ]

Gene ID: 54112, updated on 27-Nov-2024

Summary

Official Symbol
GPR88provided by HGNC
Official Full Name
G protein-coupled receptor 88provided by HGNC
Primary source
HGNC:HGNC:4539
See related
Ensembl:ENSG00000181656 MIM:607468; AllianceGenome:HGNC:4539
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
STRG; COCPMR
Summary
The protein encoded by this gene is a G protein-coupled receptor found almost exclusively in the striatum, a brain structure that controls motor function and cognition. Defects in this gene have been associated with chorea, speech delay, and learning difficulties, as well as some neuropsychiatric disorders. [provided by RefSeq, Mar 2017]
Expression
Biased expression in spleen (RPKM 5.3), liver (RPKM 2.4) and 4 other tissues See more
Orthologs
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Genomic context

See GPR88 in Genome Data Viewer
Location:
1p21.2
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (100538139..100542021)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (100386520..100390416)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (101003695..101007577)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene cell division cycle 14A Neighboring gene uncharacterized LOC105379827 Neighboring gene BCAS2 pseudogene 2 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr1:100927704-100928325 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1383 Neighboring gene Sharpr-MPRA regulatory region 2368 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:101004119-101004968 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:101004969-101005817 Neighboring gene HNF4 motif-containing MPRA enhancer 127 Neighboring gene ribosomal protein L7a pseudogene 17 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:101088137-101088435 Neighboring gene long intergenic non-protein coding RNA 1349

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled photoreceptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables beta2-adrenergic receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables cytoskeletal motor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in G protein-coupled receptor signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in adrenergic receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to light stimulus IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in detection of visible light IEA
Inferred from Electronic Annotation
more info
 
involved_in locomotory behavior IEA
Inferred from Electronic Annotation
more info
 
involved_in motor learning ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in neuromuscular process controlling balance IEA
Inferred from Electronic Annotation
more info
 
involved_in neuronal action potential IEA
Inferred from Electronic Annotation
more info
 
involved_in phototransduction IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in ciliary membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in cilium IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
G protein-coupled receptor 88
Names
probable G-protein coupled receptor 88
striatum-specific G-protein coupled receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_053134.1 RefSeqGene

    Range
    4968..8850
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_022049.3NP_071332.2  G protein-coupled receptor 88

    See identical proteins and their annotated locations for NP_071332.2

    Status: REVIEWED

    Source sequence(s)
    AC099670, BC036775
    Consensus CDS
    CCDS772.1
    UniProtKB/Swiss-Prot
    Q29S24, Q6VN48, Q9GZN0
    Related
    ENSP00000314223.4, ENST00000315033.5
    Conserved Domains (1) summary
    cd15211
    Location:33347
    7tmA_GPR88-like; G protein-coupled receptor 88, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    100538139..100542021
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    100386520..100390416
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)