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CHRAC1 chromatin accessibility complex subunit 1 [ Homo sapiens (human) ]

Gene ID: 54108, updated on 7-Jun-2020

Summary

Official Symbol
CHRAC1provided by HGNC
Official Full Name
chromatin accessibility complex subunit 1provided by HGNC
Primary source
HGNC:HGNC:13544
See related
Ensembl:ENSG00000104472 MIM:607268
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
YCL1; CHARC1; CHARC15; CHRAC-1; CHRAC15; CHRAC-15
Summary
CHRAC1 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers combine within larger enzymatic complexes for DNA transcription, replication, and packaging.[supplied by OMIM, Apr 2004]
Expression
Ubiquitous expression in thyroid (RPKM 10.5), lymph node (RPKM 9.8) and 25 other tissues See more
Orthologs

Genomic context

See CHRAC1 in Genome Data Viewer
Location:
8q24.3
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (140511322..140517154)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (141521397..141527252)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene trafficking protein particle complex 9 Neighboring gene Sharpr-MPRA regulatory region 993 Neighboring gene uncharacterized LOC105375782 Neighboring gene MAGE-like protein 2 Neighboring gene argonaute RISC catalytic component 2 Neighboring gene protein tyrosine kinase 2 Neighboring gene microRNA 151a

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding NAS
Non-traceable Author Statement
more info
PubMed 
DNA-directed DNA polymerase activity NAS
Non-traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
DNA biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
chromatin remodeling NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
CHRAC IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
CHRAC NAS
Non-traceable Author Statement
more info
PubMed 
epsilon DNA polymerase complex NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
chromatin accessibility complex protein 1
Names
DNA polymerase epsilon subunit p15
chromatin accessibility complex 1
chromatin accessibility complex 15 kDa protein
histone-fold protein CHRAC15

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017444.6NP_059140.1  chromatin accessibility complex protein 1

    See identical proteins and their annotated locations for NP_059140.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the functional protein.
    Source sequence(s)
    AC107375, AK023537
    Consensus CDS
    CCDS6379.1
    UniProtKB/Swiss-Prot
    Q9NRG0
    Related
    ENSP00000220913.5, ENST00000220913.10
    Conserved Domains (1) summary
    cl28542
    Location:1597
    BUR6; Class 2 transcription repressor NC2, alpha subunit (DRAP1 homolog) [Transcription]

RNA

  1. NR_023360.3 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) omits a coding exon resulting in a frameshift and truncation of the open reading frame. The predicted protein would be only 56 amino acids in length. It is not known if a protein is actually encoded from this transcript.
    Source sequence(s)
    AC107375, AK308709, DA647606
  2. NR_040712.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate 5' exon, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
    Source sequence(s)
    AC107375, BU160855

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    140511322..140517154
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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