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PNLIPRP2 pancreatic lipase related protein 2 (gene/pseudogene) [ Homo sapiens (human) ]

Gene ID: 5408, updated on 17-Jun-2024

Summary

Official Symbol
PNLIPRP2provided by HGNC
Official Full Name
pancreatic lipase related protein 2 (gene/pseudogene)provided by HGNC
Primary source
HGNC:HGNC:9157
See related
Ensembl:ENSG00000266200 MIM:604423; AllianceGenome:HGNC:9157
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PLRP2
Summary
This gene encodes a lipase that hydrolyzes galactolipids, the main components of plant membrane lipids. An allelic polymorphism in this gene results in both coding and non-coding variants; the reference genome represents the non-coding allele. [provided by RefSeq, Aug 2015]
Annotation information
Note: Genetic polymorphisms result in both protein coding and non-coding alleles of this gene.
Expression
Restricted expression toward pancreas (RPKM 1148.7) See more
Orthologs
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Genomic context

See PNLIPRP2 in Genome Data Viewer
Location:
10q25.3
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (116620953..116645143)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (117515050..117539456)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (118380465..118404654)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene ReSE screen-validated silencer GRCh37_chr10:118347975-118348179 Neighboring gene pancreatic lipase pseudogene 1 Neighboring gene uncharacterized LOC124902510 Neighboring gene pancreatic lipase related protein 1 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr10:118393650-118394849 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:118405699-118406228 Neighboring gene HSPA12A antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 10762 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:118441833-118442334 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:118442335-118442834 Neighboring gene sperm microtubule inner protein 5 Neighboring gene heat shock protein family A (Hsp70) member 12A Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:118450610-118451348 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:118453631-118454602 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:118501942-118502646 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:118502647-118503350 Neighboring gene ribosomal protein L5 pseudogene 27

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 1-18:1-2-16:0-monogalactosyldiacylglycerol lipase activity IEA
Inferred from Electronic Annotation
more info
 
enables acylglycerol lipase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables acylglycerol lipase activity TAS
Traceable Author Statement
more info
 
enables calcium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables galactolipase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables galactolipase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables phospholipase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables phospholipase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables triglyceride lipase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables triglyceride lipase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables triglyceride lipase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in galactolipid catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in lipid digestion TAS
Traceable Author Statement
more info
 
involved_in phosphatidylcholine catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in phospholipid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in phospholipid catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in triglyceride catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in triglyceride catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in triglyceride catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in triglyceride metabolic process TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in extracellular region TAS
Traceable Author Statement
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuron projection ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in zymogen granule membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
pancreatic lipase-related protein 2
Names
cytotoxic T lymphocyte lipase
galactolipase
triacylglycerol lipase
NP_005387.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005396.5NP_005387.3  pancreatic lipase-related protein 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1, coding) differs at a polymorphic nucleotide compared to the reference genome sequence and represents the protein coding allele.
    Source sequence(s)
    BC005989, BP325072, BQ786898, BU078199
    UniProtKB/Swiss-Prot
    A0A075B781, A8K627, P54317, Q6IB55
    Conserved Domains (2) summary
    cd01759
    Location:357469
    PLAT_PL; PLAT/LH2 domain of pancreatic triglyceride lipase. Lipases hydrolyze phospholipids and triglycerides to generate fatty acids for energy production or for storage and to release inositol phosphates that act as second messengers. The central role of ...
    pfam00151
    Location:18354
    Lipase

RNA

  1. NR_103727.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1, non-coding) contains a polymorphic nt that creates an early termination codon compared to variant 1, coding. The resulting transcript is considered to be non-protein coding since it is a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA367174, AK291492, BQ786898, M93284
    Related
    ENST00000579578.6

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    116620953..116645143
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_025791790.1 Reference GRCh38.p14 PATCHES

    Range
    31949..56139
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    117515050..117539456
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)