Format

Send to:

Choose Destination

PNLIPRP2 pancreatic lipase related protein 2 (gene/pseudogene) [ Homo sapiens (human) ]

Gene ID: 5408, updated on 21-Dec-2019

Summary

Official Symbol
PNLIPRP2provided by HGNC
Official Full Name
pancreatic lipase related protein 2 (gene/pseudogene)provided by HGNC
Primary source
HGNC:HGNC:9157
See related
Ensembl:ENSG00000266200 MIM:604423
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PLRP2
Summary
This gene encodes a lipase that hydrolyzes galactolipids, the main components of plant membrane lipids. An allelic polymorphism in this gene results in both coding and non-coding variants; the reference genome represents the non-coding allele. [provided by RefSeq, Aug 2015]
Expression
Restricted expression toward pancreas (RPKM 1148.7) See more
Orthologs

Genomic context

See PNLIPRP2 in Genome Data Viewer
Location:
10q25.3
Exon count:
13
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (116620953..116645143)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (118380465..118404654)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene pancreatic lipase pseudogene 1 Neighboring gene pancreatic lipase related protein 1 Neighboring gene uncharacterized LOC105378499 Neighboring gene Sharpr-MPRA regulatory region 10762 Neighboring gene chromosome 10 open reading frame 82 Neighboring gene heat shock protein family A (Hsp70) member 12A

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
1-18:1-2-16:0-monogalactosyldiacylglycerol lipase activity IEA
Inferred from Electronic Annotation
more info
 
acylglycerol lipase activity IDA
Inferred from Direct Assay
more info
PubMed 
calcium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
galactolipase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
galactolipase activity IDA
Inferred from Direct Assay
more info
PubMed 
lipase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phospholipase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phospholipase activity IDA
Inferred from Direct Assay
more info
PubMed 
triglyceride lipase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
triglyceride lipase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
cellular defense response IEA
Inferred from Electronic Annotation
more info
 
galactolipid catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
intestinal lipid catabolic process IEA
Inferred from Electronic Annotation
more info
 
lipid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lipid digestion TAS
Traceable Author Statement
more info
 
phospholipid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phospholipid catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
response to bacterium IEA
Inferred from Electronic Annotation
more info
 
triglyceride metabolic process TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
pancreatic lipase-related protein 2
Names
PL-RP2
galactolipase

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005396.5NP_005387.3  pancreatic lipase-related protein 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1, coding) differs at a polymorphic nucleotide compared to the reference genome sequence and represents the protein coding allele.
    Source sequence(s)
    BC005989, BP325072, BQ786898, BU078199

RNA

  1. NR_103727.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1, non-coding) contains a polymorphic nt that creates an early termination codon compared to variant 1, coding. The resulting transcript is considered to be non-protein coding since it is a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA367174, AK291492, BQ786898, M93284
    Related
    ENST00000579578.6

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    116620953..116645143
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center