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BMP7 bone morphogenetic protein 7 [ Bos taurus (domestic cattle) ]

Gene ID: 540595, updated on 30-Jan-2025
Official Symbol
BMP7provided by VGNC
Official Full Name
bone morphogenetic protein 7provided by VGNC
Primary source
VGNC:VGNC:26522
See related
BGD:BT11710; EnsemblRapid:ENSBTAG00070032259
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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See BMP7 in Genome Data Viewer
Location:
chromosome: 13
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 13 NC_037340.1 (58889622..58975046)

Chromosome 13 - NC_037340.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC132346941 Neighboring gene SPO11 initiator of meiotic double stranded breaks Neighboring gene microRNA mir-2307 Neighboring gene uncharacterized LOC132346942 Neighboring gene transfer RNA glycine (anticodon UCC)

Genomic Sequence:
NC_037340.1 Chromosome 13 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Related articles in PubMed

  1. The differential pathways of bone morphogenetic protein (BMP)-4 and -7 in the suppression of the bovine granulosa cell apoptosis. Kayamori T, et al. Mol Cell Biochem, 2009 Mar. PMID 19083154
  2. Induction of chondrogenesis and expression of superficial zone protein in synovial explants with TGF-β1 and BMP-7. Iwakura T, et al. Tissue Eng Part A, 2013 Dec. PMID 23848497, Free PMC Article
  3. Identification and genetic effect of haplotype in the bovine BMP7 gene. Huang YZ, et al. Gene, 2013 Dec 15. PMID 23500594
  4. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. the combined treatment with TGF-beta1 and BMP-7 or treatment first with TGF-beta1 followed by BMP-7 was more effective than other treatment groups in both chondrogenic differentiation and SZP secretion.
    Title: Induction of chondrogenesis and expression of superficial zone protein in synovial explants with TGF-β1 and BMP-7.
  2. Some single nucleotide polymorphisms and haplotypes in BMP7 are associated with cattle growth traits.
    Title: Identification and genetic effect of haplotype in the bovine BMP7 gene.
  3. Data report that BMP-7 suppresses granulosa cell apoptosis by inhibiting the release of caspase-activated DNase (CAD) via a mechanism which does not appear to be associated with the mitochondrial pathway, whereas BMP-4 inhibits the release of CAD.
    Title: The differential pathways of bone morphogenetic protein (BMP)-4 and -7 in the suppression of the bovine granulosa cell apoptosis.
Submit: New GeneRIF Correction

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables cytokine activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in BMP signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
bone morphogenetic protein 7
Names
bone morphogenetic protein 7 (osteogenic protein 1)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001206015.1 → NP_001192944.1  bone morphogenetic protein 7 precursor

    See identical proteins and their annotated locations for NP_001192944.1

    Status: PROVISIONAL

    Source sequence(s)
    NKLS02000013
    UniProtKB/TrEMBL
    A0AAA9SW88, F1MLT0
    Related
    ENSBTAP00070044440.1, ENSBTAT00070072974.1
    Conserved Domains (2) summary
    cd19397
    Location:325 → 431
    TGF_beta_BMP7; transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 7 (BMP-7) and similar proteins
    pfam00688
    Location:35 → 280
    TGFb_propeptide; TGF-beta propeptide

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037340.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    58889622..58975046
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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