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C21orf58 chromosome 21 open reading frame 58 [ Homo sapiens (human) ]

Gene ID: 54058, updated on 23-Nov-2021

Summary

Official Symbol
C21orf58provided by HGNC
Official Full Name
chromosome 21 open reading frame 58provided by HGNC
Primary source
HGNC:HGNC:1300
See related
Ensembl:ENSG00000160298
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Broad expression in bone marrow (RPKM 2.0), testis (RPKM 2.0) and 24 other tissues See more
Orthologs
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Genomic context

See C21orf58 in Genome Data Viewer
Location:
21q22.3
Exon count:
12
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 21 NC_000021.9 (46300426..46324046, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (47720344..47743784, complement)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 4411 Neighboring gene Sharpr-MPRA regulatory region 1466 Neighboring gene ybeY metalloendoribonuclease Neighboring gene pericentrin Neighboring gene ribosomal protein L18a pseudogene 2 Neighboring gene DIP2A intronic transcript 1 Neighboring gene disco interacting protein 2 homolog A

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

General protein information

Preferred Names
uncharacterized protein C21orf58

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286462.2NP_001273391.1  uncharacterized protein C21orf58 isoform 2

    See identical proteins and their annotated locations for NP_001273391.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' terminal exon, uses alternate acceptor splice sites at 2 internal exons and is alternatively spliced at the 3' end compared to variant 1. The differences at the 5' end result in translation initiation from an alternate start codon, and a shorter isoform (2) with a distinct N-terminus compared to isoform 1. Variants 2-5 encode the same isoform.
    Source sequence(s)
    AK056387, BC028934, CB305953
    Consensus CDS
    CCDS68229.1
    UniProtKB/Swiss-Prot
    P58505
    Related
    ENSP00000380799.1, ENST00000397683.5
    Conserved Domains (1) summary
    pfam15248
    Location:128185
    DUF4587; Domain of unknown function (DUF4587)
  2. NM_001286463.1NP_001273392.1  uncharacterized protein C21orf58 isoform 2

    See identical proteins and their annotated locations for NP_001273392.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses alternate acceptor splice sites at 2 internal exons that results in translation initiation from an alternate start codon compared to variant 1. The resulting shorter isoform (2) has a distinct N-terminus compared to isoform 1. Variants 2-5 encode the same isoform.
    Source sequence(s)
    AK056387, AK096641, AK098098, BM475055
    Consensus CDS
    CCDS68229.1
    UniProtKB/Swiss-Prot
    P58505
    Related
    ENSP00000380796.1, ENST00000397679.5
    Conserved Domains (1) summary
    pfam15248
    Location:128185
    DUF4587; Domain of unknown function (DUF4587)
  3. NM_001286476.2NP_001273405.1  uncharacterized protein C21orf58 isoform 2

    See identical proteins and their annotated locations for NP_001273405.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses alternate acceptor splice sites at 2 internal exons and is alternatively spliced at the 3' end compared to variant 1. The differences at the 5' end result in translation initiation from an alternate start codon, and a shorter isoform (2) with a distinct N-terminus compared to isoform 1. Variants 2-5 encode the same isoform.
    Source sequence(s)
    AP000471
    Consensus CDS
    CCDS68229.1
    UniProtKB/Swiss-Prot
    P58505
    Related
    ENSP00000380798.3, ENST00000397682.7
    Conserved Domains (1) summary
    pfam15248
    Location:128185
    DUF4587; Domain of unknown function (DUF4587)
  4. NM_001286477.2NP_001273406.1  uncharacterized protein C21orf58 isoform 2

    See identical proteins and their annotated locations for NP_001273406.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses alternate splice sites at the 5' terminal exon and an internal exon that results in translation initiation from an alternate start codon compared to variant 1. The resulting shorter isoform (2) has a distinct N-terminus compared to isoform 1. Variants 2-5 encode the same isoform.
    Source sequence(s)
    AP000471
    Consensus CDS
    CCDS68229.1
    UniProtKB/Swiss-Prot
    P58505
    Related
    ENSP00000380797.1, ENST00000397680.5
    Conserved Domains (1) summary
    pfam15248
    Location:128185
    DUF4587; Domain of unknown function (DUF4587)
  5. NM_058180.5NP_478060.2  uncharacterized protein C21orf58 isoform 1

    See identical proteins and their annotated locations for NP_478060.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AP000471
    Consensus CDS
    CCDS13735.1
    UniProtKB/Swiss-Prot
    P58505
    Related
    ENSP00000291691.8, ENST00000291691.12
    Conserved Domains (1) summary
    pfam15248
    Location:234291
    DUF4587; Domain of unknown function (DUF4587)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p13 Primary Assembly

    Range
    46300426..46324046 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006724018.4XP_006724081.1  uncharacterized protein C21orf58 isoform X3

    UniProtKB/Swiss-Prot
    P58505
    Related
    ENSP00000431312.1, ENST00000491666.5
    Conserved Domains (1) summary
    pfam15248
    Location:234268
    DUF4587; Domain of unknown function (DUF4587)
  2. XM_011529620.3XP_011527922.1  uncharacterized protein C21orf58 isoform X1

    See identical proteins and their annotated locations for XP_011527922.1

    UniProtKB/Swiss-Prot
    P58505
    Conserved Domains (1) summary
    pfam15248
    Location:234291
    DUF4587; Domain of unknown function (DUF4587)
  3. XM_011529619.3XP_011527921.1  uncharacterized protein C21orf58 isoform X1

    See identical proteins and their annotated locations for XP_011527921.1

    UniProtKB/Swiss-Prot
    P58505
    Conserved Domains (1) summary
    pfam15248
    Location:234291
    DUF4587; Domain of unknown function (DUF4587)
  4. XM_005261148.5XP_005261205.1  uncharacterized protein C21orf58 isoform X1

    See identical proteins and their annotated locations for XP_005261205.1

    UniProtKB/Swiss-Prot
    P58505
    Conserved Domains (1) summary
    pfam15248
    Location:234291
    DUF4587; Domain of unknown function (DUF4587)
  5. XM_011529623.3XP_011527925.1  uncharacterized protein C21orf58 isoform X2

    Conserved Domains (1) summary
    pfam15248
    Location:207264
    DUF4587; Domain of unknown function (DUF4587)
  6. XM_017028392.1XP_016883881.1  uncharacterized protein C21orf58 isoform X6

    UniProtKB/Swiss-Prot
    P58505
    Conserved Domains (1) summary
    pfam15248
    Location:128185
    DUF4587; Domain of unknown function (DUF4587)
  7. XM_011529625.2XP_011527927.1  uncharacterized protein C21orf58 isoform X5

    See identical proteins and their annotated locations for XP_011527927.1

    UniProtKB/Swiss-Prot
    P58505
    Related
    ENSP00000402356.1, ENST00000417060.5
    Conserved Domains (1) summary
    pfam15248
    Location:151208
    DUF4587; Domain of unknown function (DUF4587)
  8. XM_017028393.1XP_016883882.1  uncharacterized protein C21orf58 isoform X6

    UniProtKB/Swiss-Prot
    P58505
    Conserved Domains (1) summary
    pfam15248
    Location:128185
    DUF4587; Domain of unknown function (DUF4587)
  9. XM_011529624.2XP_011527926.1  uncharacterized protein C21orf58 isoform X4

    Conserved Domains (1) summary
    pfam15248
    Location:169226
    DUF4587; Domain of unknown function (DUF4587)
  10. XM_011529628.2XP_011527930.1  uncharacterized protein C21orf58 isoform X7

RNA

  1. XR_002958618.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_199071.2: Suppressed sequence

    Description
    NM_199071.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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