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PRKAA1 protein kinase AMP-activated catalytic subunit alpha 1 [ Bos taurus (domestic cattle) ]

Gene ID: 540404, updated on 1-Jan-2025

Summary

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Official Symbol
PRKAA1provided by VGNC
Official Full Name
protein kinase AMP-activated catalytic subunit alpha 1provided by VGNC
Primary source
VGNC:VGNC:50248
See related
Ensembl:ENSBTAG00000000013
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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See PRKAA1 in Genome Data Viewer
Location:
chromosome: 20
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 20 NC_037347.1 (33674655..33703224)

Chromosome 20 - NC_037347.1Genomic Context describing neighboring genes Neighboring gene caspase recruitment domain family member 6 Neighboring gene small nucleolar RNA SNORD72 Neighboring gene ribosomal protein L37 Neighboring gene tetratricopeptide repeat domain 33 Neighboring gene prostaglandin E receptor 4

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037347.1 Chromosome 20 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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Related articles in PubMed

  1. Glucose Availability and AMP-Activated Protein Kinase Link Energy Metabolism and Innate Immunity in the Bovine Endometrium. Turner ML, et al. PLoS One, 2016. PMID 26974839, Free PMC Article
  2. Energy depletion of bovine mammary epithelial cells activates AMPK and suppresses protein synthesis through inhibition of mTORC1 signaling. Burgos SA, et al. Horm Metab Res, 2013 Mar. PMID 22972179
  3. Ischemia-induced stimulation of Na-K-Cl cotransport in cerebral microvascular endothelial cells involves AMP kinase. Wallace BK, et al. Am J Physiol Cell Physiol, 2011 Aug. PMID 21562306, Free PMC Article
  4. Redox regulation of the AMP-activated protein kinase. Han Y, et al. PLoS One, 2010 Nov 5. PMID 21079763, Free PMC Article
  5. Effects of adenosine monophosphate-activated kinase activators on bovine oocyte nuclear maturation in vitro. Bilodeau-Goeseels S, et al. Mol Reprod Dev, 2007 Aug. PMID 17290417

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Endometrial inflammatory responses to lipopolysaccharide were also reduced by small molecules that activate or inhibit the intracellular sensor of energy, AMP-activated protein kinase (AMPK).
    Title: Glucose Availability and AMP-Activated Protein Kinase Link Energy Metabolism and Innate Immunity in the Bovine Endometrium.
  2. The results suggest that activation of AMPK represses global protein synthesis in mammary epithelial cells through inhibition of mTORC1 signaling.
    Title: Energy depletion of bovine mammary epithelial cells activates AMPK and suppresses protein synthesis through inhibition of mTORC1 signaling.
  3. Findings suggest that ischemic factor stimulation of the blood brain barrier Na-K-Cl cotransporter involves activation of AMPK.
    Title: Ischemia-induced stimulation of Na-K-Cl cotransport in cerebral microvascular endothelial cells involves AMP kinase.
  4. Results suggest that mitochondria-derived superoxide anions and peroxynitrite are required for Berberine-induced AMPK activation in endothelial cells.
    Title: Redox regulation of the AMP-activated protein kinase.
  5. the expression, but not the kinase activity, of AMPK and CaMKKbeta is necessary for ADP signaling to eNOS
    Title: ADP signaling in vascular endothelial cells: ADP-dependent activation of the endothelial isoform of nitric-oxide synthase requires the expression but not the kinase activity of AMP-activated protein kinase.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC165837

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables AMP-activated protein kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
5'-AMP-activated protein kinase catalytic subunit alpha-1
Names
protein kinase, AMP-activated, alpha 1 catalytic subunit
NP_001103272.1
XP_005221614.1
XP_024837129.1
XP_024837130.1
XP_059734756.1
XP_059734757.1
XP_059734758.1
XP_059734759.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109802.2 → NP_001103272.1  5'-AMP-activated protein kinase catalytic subunit alpha-1

    See identical proteins and their annotated locations for NP_001103272.1

    Status: PROVISIONAL

    Source sequence(s)
    BC153842
    UniProtKB/TrEMBL
    A8E649
    Related
    ENSBTAP00000000016.4, ENSBTAT00000000016.5
    Conserved Domains (3) summary
    cd12199
    Location:303 → 456
    AMPKA1_C; C-terminal regulatory domain of 5'-AMP-activated protein kinase (AMPK) alpha 1 catalytic subunit
    cd14403
    Location:195 → 259
    UBA_AID_AAPK1; UBA-like autoinhibitory domain (AID) found in vertebrate 5'-AMP-activated protein kinase catalytic subunit alpha-1 (AMPKalpha-1)
    cl21453
    Location:1 → 178
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037347.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    33674655..33703224
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005221557.4 → XP_005221614.1  5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X2

    See identical proteins and their annotated locations for XP_005221614.1

    Conserved Domains (3) summary
    cd12199
    Location:404 → 557
    AMPKA1_C; C-terminal regulatory domain of 5'-AMP-activated protein kinase (AMPK) alpha 1 catalytic subunit
    cd14403
    Location:296 → 360
    UBA_AID_AAPK1; UBA-like autoinhibitory domain (AID) found in vertebrate 5'-AMP-activated protein kinase catalytic subunit alpha-1 (AMPKalpha-1)
    cd14079
    Location:24 → 279
    STKc_AMPK_alpha; Catalytic domain of the Alpha subunit of the Serine/Threonine Kinase, AMP-activated protein kinase

  2. XM_024981361.2 → XP_024837129.1  5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1

    UniProtKB/TrEMBL
    A0AAA9T3X0
    Related
    ENSBTAP00000091349.1, ENSBTAT00000090743.1
    Conserved Domains (3) summary
    cd12199
    Location:419 → 572
    AMPKA1_C; C-terminal regulatory domain of 5'-AMP-activated protein kinase (AMPK) alpha 1 catalytic subunit
    cd14403
    Location:311 → 375
    UBA_AID_AAPK1; UBA-like autoinhibitory domain (AID) found in vertebrate 5'-AMP-activated protein kinase catalytic subunit alpha-1 (AMPKalpha-1)
    cd14079
    Location:24 → 294
    STKc_AMPK_alpha; Catalytic domain of the Alpha subunit of the Serine/Threonine Kinase, AMP-activated protein kinase

  3. XM_059878775.1 → XP_059734758.1  5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X3

  4. XM_059878773.1 → XP_059734756.1  5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X3

  5. XM_024981362.2 → XP_024837130.1  5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X4

    Conserved Domains (3) summary
    cd12199
    Location:260 → 413
    AMPKA1_C; C-terminal regulatory domain of 5'-AMP-activated protein kinase (AMPK) alpha 1 catalytic subunit
    cd14403
    Location:152 → 216
    UBA_AID_AAPK1; UBA-like autoinhibitory domain (AID) found in vertebrate 5'-AMP-activated protein kinase catalytic subunit alpha-1 (AMPKalpha-1)
    cl21453
    Location:1 → 135
    PKc_like; Protein Kinases, catalytic domain

  6. XM_059878774.1 → XP_059734757.1  5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X3

  7. XM_059878776.1 → XP_059734759.1  5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X3

Nucleotide Protein Strain
Heading Accession and Version

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