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Nell2 NEL-like 2 [ Mus musculus (house mouse) ]

Gene ID: 54003, updated on 5-Jan-2022

Summary

Official Symbol
Nell2provided by MGI
Official Full Name
NEL-like 2provided by MGI
Primary source
MGI:MGI:1858510
See related
Ensembl:ENSMUSG00000022454
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mel91; R75516; A330108N19Rik
Summary
Predicted to enable heparin binding activity; identical protein binding activity; and protein kinase C binding activity. Predicted to be involved in several processes, including development of secondary female sexual characteristics; neuron cellular homeostasis; and positive regulation of hormone secretion. Predicted to be located in several cellular components, including dendrite; extracellular space; and perikaryon. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; axial skeleton; central nervous system; limb mesenchyme; and sensory organ. Orthologous to human NELL2 (neural EGFL like 2). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in cortex adult (RPKM 60.0), frontal lobe adult (RPKM 49.2) and 7 other tissues See more
Orthologs
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Genomic context

See Nell2 in Genome Data Viewer
Location:
15; 15 E3
Exon count:
23
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (95117321..95426677, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (95219440..95528796, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (95049881..95359137, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100043315 Neighboring gene predicted gene, 31075 Neighboring gene predicted gene, 31370 Neighboring gene predicted gene, 31551 Neighboring gene predicted gene, 24668

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables heparin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables heparin binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase C binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein kinase C binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in development of secondary female sexual characteristics ISO
Inferred from Sequence Orthology
more info
 
involved_in fertilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuron cellular homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of hormone secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of growth ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in perikaryon ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
protein kinase C-binding protein NELL2
Names
NEL-like protein 2
nel-like 2 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289653.1NP_001276582.1  protein kinase C-binding protein NELL2 precursor

    See identical proteins and their annotated locations for NP_001276582.1

    Status: VALIDATED

    Source sequence(s)
    AC109198, AC163991, AC164402
    Consensus CDS
    CCDS27775.1
    UniProtKB/Swiss-Prot
    Q61220
    Related
    ENSMUSP00000074751.3, ENSMUST00000075275.3
    Conserved Domains (5) summary
    smart00179
    Location:558592
    EGF_CA; Calcium-binding EGF-like domain
    smart00210
    Location:32217
    TSPN; Thrombospondin N-terminal -like domains
    pfam07645
    Location:605636
    EGF_CA; Calcium-binding EGF domain
    cl17735
    Location:277333
    VWC; von Willebrand factor type C domain
    pfam12947
    Location:489524
    EGF_3; EGF domain
  2. NM_001356950.1NP_001343879.1  protein kinase C-binding protein NELL2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC109198, AC163991, AC164402
    Consensus CDS
    CCDS27775.1
    Related
    ENSMUSP00000131665.2, ENSMUST00000166170.9
    Conserved Domains (5) summary
    smart00179
    Location:558592
    EGF_CA; Calcium-binding EGF-like domain
    smart00210
    Location:32217
    TSPN; Thrombospondin N-terminal -like domains
    pfam07645
    Location:605636
    EGF_CA; Calcium-binding EGF domain
    cl17735
    Location:277333
    VWC; von Willebrand factor type C domain
    pfam12947
    Location:489524
    EGF_3; EGF domain
  3. NM_001356951.1NP_001343880.1  protein kinase C-binding protein NELL2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC109198, AC163991, AC164402
    Consensus CDS
    CCDS27775.1
    Related
    ENSMUSP00000155490.2, ENSMUST00000229981.2
    Conserved Domains (5) summary
    smart00179
    Location:558592
    EGF_CA; Calcium-binding EGF-like domain
    smart00210
    Location:32217
    TSPN; Thrombospondin N-terminal -like domains
    pfam07645
    Location:605636
    EGF_CA; Calcium-binding EGF domain
    cl17735
    Location:277333
    VWC; von Willebrand factor type C domain
    pfam12947
    Location:489524
    EGF_3; EGF domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    95117321..95426677 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006521163.3XP_006521226.1  protein kinase C-binding protein NELL2 isoform X1

    See identical proteins and their annotated locations for XP_006521226.1

    UniProtKB/Swiss-Prot
    Q61220
    Conserved Domains (5) summary
    smart00179
    Location:558592
    EGF_CA; Calcium-binding EGF-like domain
    smart00210
    Location:32217
    TSPN; Thrombospondin N-terminal -like domains
    pfam07645
    Location:605636
    EGF_CA; Calcium-binding EGF domain
    cl17735
    Location:277333
    VWC; von Willebrand factor type C domain
    pfam12947
    Location:489524
    EGF_3; EGF domain
  2. XM_036159519.1XP_036015412.1  protein kinase C-binding protein NELL2 isoform X2

    Conserved Domains (6) summary
    smart00179
    Location:558592
    EGF_CA; Calcium-binding EGF-like domain
    smart00210
    Location:32217
    TSPN; Thrombospondin N-terminal -like domains
    pfam00093
    Location:277333
    VWC; von Willebrand factor type C domain
    pfam07645
    Location:605636
    EGF_CA; Calcium-binding EGF domain
    cl17735
    Location:708758
    VWC; von Willebrand factor type C domain
    pfam12947
    Location:489524
    EGF_3; EGF domain
  3. XM_006521164.5XP_006521227.1  protein kinase C-binding protein NELL2 isoform X2

    Related
    ENSMUSP00000155436.2, ENSMUST00000229933.2
    Conserved Domains (6) summary
    smart00179
    Location:558592
    EGF_CA; Calcium-binding EGF-like domain
    smart00210
    Location:32217
    TSPN; Thrombospondin N-terminal -like domains
    pfam00093
    Location:277333
    VWC; von Willebrand factor type C domain
    pfam07645
    Location:605636
    EGF_CA; Calcium-binding EGF domain
    cl17735
    Location:708758
    VWC; von Willebrand factor type C domain
    pfam12947
    Location:489524
    EGF_3; EGF domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_016743.2: Suppressed sequence

    Description
    NM_016743.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
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