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Ddx20 DEAD box helicase 20 [ Mus musculus (house mouse) ]

Gene ID: 53975, updated on 11-Jun-2024

Summary

Official Symbol
Ddx20provided by MGI
Official Full Name
DEAD box helicase 20provided by MGI
Primary source
MGI:MGI:1858415
See related
Ensembl:ENSMUSG00000027905 AllianceGenome:MGI:1858415
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
dp103; GEMIN3
Summary
Enables histone deacetylase binding activity and protein-macromolecule adaptor activity. Involved in positive regulation of apoptotic process. Acts upstream of or within negative regulation of transcription by RNA polymerase II; oogenesis; and regulation of steroid biosynthetic process. Part of RNA polymerase II transcription repressor complex. Is expressed in several structures, including branchial arch; genitourinary system; liver; lung; and spleen. Orthologous to human DDX20 (DEAD-box helicase 20). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 40.1), ovary adult (RPKM 10.1) and 23 other tissues See more
Orthologs
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Genomic context

See Ddx20 in Genome Data Viewer
Location:
3 F2.2; 3 46.43 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (105585586..105595104, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (105678270..105687788, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 34837 Neighboring gene STARR-seq mESC enhancer starr_08632 Neighboring gene STARR-seq mESC enhancer starr_08634 Neighboring gene potassium voltage-gated channel, Shal-related family, member 3, opposite strand Neighboring gene potassium voltage-gated channel, Shal-related family, member 3 Neighboring gene STARR-positive B cell enhancer ABC_E6095 Neighboring gene STARR-positive B cell enhancer ABC_E8804 Neighboring gene STARR-positive B cell enhancer ABC_E2091 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:105507469-105507578 Neighboring gene inka box actin regulator 2 Neighboring gene RAS-related protein 1a Neighboring gene STARR-positive B cell enhancer ABC_E10203 Neighboring gene STARR-positive B cell enhancer ABC_E11208

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (4)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Clone Names

  • MGC159174

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables helicase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone deacetylase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
enables protein-macromolecule adaptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ribonucleoside triphosphate phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of RNA polymerase II transcription repressor complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of SMN complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of SMN complex ISO
Inferred from Sequence Orthology
more info
 
part_of SMN-Sm protein complex ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
part_of transcription repressor complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
probable ATP-dependent RNA helicase DDX20
Names
DEAD (Asp-Glu-Ala-Asp) box polypeptide 20
DEAD box protein 20
DEAD box protein DP 103
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 20
ROSF-1
component of gems 3
gemin-3
regulator of steroidogenic factor 1
NP_059093.3
XP_006501764.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017397.3NP_059093.3  probable ATP-dependent RNA helicase DDX20

    See identical proteins and their annotated locations for NP_059093.3

    Status: PROVISIONAL

    Source sequence(s)
    BC125471
    Consensus CDS
    CCDS38581.1
    UniProtKB/Swiss-Prot
    Q059Z6, Q9JIK4, Q9JJY4
    UniProtKB/TrEMBL
    Q8R4Z6
    Related
    ENSMUSP00000088176.7, ENSMUST00000090680.11
    Conserved Domains (2) summary
    PRK01297
    Location:18413
    PRK01297; ATP-dependent RNA helicase RhlB; Provisional
    cd17943
    Location:74266
    DEADc_DDX20; DEAD-box helicase domain of DEAD box protein 20

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    105585586..105595104 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006501701.4XP_006501764.1  probable ATP-dependent RNA helicase DDX20 isoform X1

    See identical proteins and their annotated locations for XP_006501764.1

    UniProtKB/Swiss-Prot
    Q059Z6, Q9JIK4, Q9JJY4
    UniProtKB/TrEMBL
    Q8R4Z6
    Conserved Domains (2) summary
    PRK01297
    Location:18413
    PRK01297; ATP-dependent RNA helicase RhlB; Provisional
    cd17943
    Location:74266
    DEADc_DDX20; DEAD-box helicase domain of DEAD box protein 20