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GLS2 glutaminase 2 [ Bos taurus (domestic cattle) ]

Gene ID: 539561, updated on 11-Jun-2025
Official Symbol
GLS2provided by VGNC
Official Full Name
glutaminase 2provided by VGNC
Primary source
VGNC:VGNC:29420
See related
BGD:BT26712; EnsemblRapid:ENSBTAG00070012040
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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See GLS2 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 5 NC_037332.1 (56910750..56923311)

Chromosome 5 - NC_037332.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112446708 Neighboring gene bromodomain adjacent to zinc finger domain 2A Neighboring gene RNA binding motif single stranded interacting protein 2 Neighboring gene SPRY domain containing 4 Neighboring gene major intrinsic protein of lens fiber Neighboring gene timeless circadian regulator

Genomic Sequence:
NC_037332.1 Chromosome 5 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Related articles in PubMed

  1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables glutaminase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in L-glutamine catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in glutamate biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
glutaminase liver isoform, mitochondrial
Names
glutaminase 2 (liver, mitochondrial)
NP_001179203.1
XP_005206712.1
XP_005206713.1
XP_005206714.1
XP_005206715.1
XP_010803507.1
XP_059742600.1
XP_059742601.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001192274.1 → NP_001179203.1  glutaminase liver isoform, mitochondrial

    Status: PROVISIONAL

    Source sequence(s)
    NKLS02000005
    UniProtKB/TrEMBL
    E1BHZ6
    Conserved Domains (4) summary
    cd00204
    Location:462 → 547
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam04960
    Location:149 → 435
    Glutaminase; Glutaminase
    pfam13637
    Location:492 → 544
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:462 → 488
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037332.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    56910750..56923311
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005206656.5 → XP_005206713.1  glutaminase liver isoform, mitochondrial isoform X2

    UniProtKB/TrEMBL
    A0AAA9SWD8
    Conserved Domains (4) summary
    cd00204
    Location:467 → 552
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam04960
    Location:154 → 440
    Glutaminase; Glutaminase
    pfam13637
    Location:497 → 549
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:467 → 493
    ANK; ANK repeat [structural motif]

  2. XM_005206655.5 → XP_005206712.1  glutaminase liver isoform, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_005206712.1

    UniProtKB/TrEMBL
    E1BHZ6
    Related
    ENSBTAP00070016254.1, ENSBTAT00070027233.1
    Conserved Domains (4) summary
    cd00204
    Location:490 → 575
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam04960
    Location:177 → 463
    Glutaminase; Glutaminase
    pfam13637
    Location:520 → 572
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:490 → 516
    ANK; ANK repeat [structural motif]

  3. XM_005206657.5 → XP_005206714.1  glutaminase liver isoform, mitochondrial isoform X4

    UniProtKB/TrEMBL
    A0AAA9U0H4
    Related
    ENSBTAP00070016243.1, ENSBTAT00070027221.1
    Conserved Domains (4) summary
    cd00204
    Location:431 → 516
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam04960
    Location:177 → 404
    Glutaminase; Glutaminase
    pfam13637
    Location:461 → 513
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:431 → 457
    ANK; ANK repeat [structural motif]

  4. XM_010805205.4 → XP_010803507.1  glutaminase liver isoform, mitochondrial isoform X7

    UniProtKB/TrEMBL
    E1BHZ6
    Conserved Domains (4) summary
    cd00204
    Location:416 → 501
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam04960
    Location:103 → 389
    Glutaminase; Glutaminase
    pfam13637
    Location:446 → 498
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:416 → 442
    ANK; ANK repeat [structural motif]

  5. XM_005206658.5 → XP_005206715.1  glutaminase liver isoform, mitochondrial isoform X6

    See identical proteins and their annotated locations for XP_005206715.1

    UniProtKB/TrEMBL
    E1BHZ6
    Conserved Domains (4) summary
    cd00204
    Location:421 → 506
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam04960
    Location:108 → 394
    Glutaminase; Glutaminase
    pfam13637
    Location:451 → 503
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:421 → 447
    ANK; ANK repeat [structural motif]

  6. XM_059886617.1 → XP_059742600.1  glutaminase liver isoform, mitochondrial isoform X3

    UniProtKB/TrEMBL
    A0AAA9TK95

  7. XM_059886618.1 → XP_059742601.1  glutaminase liver isoform, mitochondrial isoform X5

    UniProtKB/TrEMBL
    E1BHZ6
Nucleotide Protein Strain
Heading Accession and Version

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