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EXOSC10 exosome component 10 [ Homo sapiens (human) ]

Gene ID: 5394, updated on 9-Dec-2018

Summary

Official Symbol
EXOSC10provided by HGNC
Official Full Name
exosome component 10provided by HGNC
Primary source
HGNC:HGNC:9138
See related
Ensembl:ENSG00000171824 MIM:605960
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
p2; p3; p4; RRP6; PMSCL; Rrp6p; PM-Scl; PMSCL2; PM/Scl-100
Expression
Ubiquitous expression in skin (RPKM 18.4), testis (RPKM 18.0) and 25 other tissues See more
Orthologs

Genomic context

See EXOSC10 in Genome Data Viewer
Location:
1p36.22
Exon count:
25
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (11066613..11099910, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (11126675..11159961, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene TAR DNA binding protein Neighboring gene mannan binding lectin serine peptidase 2 Neighboring gene spermidine synthase Neighboring gene EXOSC10 antisense RNA 1 Neighboring gene mechanistic target of rapamycin kinase Neighboring gene MTOR antisense RNA 1 Neighboring gene RNA, U6 small nuclear 537, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of exosome component 10 (EXOSC10) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag Interaction of HIV-1 Gag with exosome component 10 (EXOSC10) is identified in a series of six affinity purification/mass spectrometry screens PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Major pathway of rRNA processing in the nucleolus and cytosol, organism-specific biosystem (from REACTOME)
    Major pathway of rRNA processing in the nucleolus and cytosol, organism-specific biosystemIn humans, a 47S precursor rRNA (pre-rRNA) is transcribed by RNA polymerase I from rRNA-encoding genes (rDNA) at the boundary of the fibrillar center and the dense fibrillar components of the nucleol...
  • RNA degradation, organism-specific biosystem (from KEGG)
    RNA degradation, organism-specific biosystemThe correct processing, quality control and turnover of cellular RNA molecules are critical to many aspects in the expression of genetic information. In eukaryotes, two major pathways of mRNA decay e...
  • RNA degradation, conserved biosystem (from KEGG)
    RNA degradation, conserved biosystemThe correct processing, quality control and turnover of cellular RNA molecules are critical to many aspects in the expression of genetic information. In eukaryotes, two major pathways of mRNA decay e...
  • rRNA processing, organism-specific biosystem (from REACTOME)
    rRNA processing, organism-specific biosystemEach eukaryotic cytosolic ribosome contains 4 molecules of RNA: 28S rRNA (25S rRNA in yeast), 5.8S rRNA, and 5S rRNA in the 60S subunit and 18S rRNA in the 40S subunit. The 18S rRNA, 5.8S rRNA, and 2...
  • rRNA processing in the nucleus and cytosol, organism-specific biosystem (from REACTOME)
    rRNA processing in the nucleus and cytosol, organism-specific biosystemEach eukaryotic cytosolic ribosome contains 4 molecules of RNA: 28S rRNA (25S rRNA in yeast), 5.8S rRNA, and 5S rRNA in the 60S subunit and 18S rRNA in the 40S subunit. The 18S rRNA, 5.8S rRNA, and 2...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
3'-5'-exoribonuclease activity EXP
Inferred from Experiment
more info
PubMed 
3'-5'-exoribonuclease activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
RNA binding HDA PubMed 
exoribonuclease activity IDA
Inferred from Direct Assay
more info
PubMed 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
telomerase RNA binding IC
Inferred by Curator
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
exosome (RNase complex) IDA
Inferred from Direct Assay
more info
PubMed 
membrane HDA PubMed 
nuclear exosome (RNase complex) IDA
Inferred from Direct Assay
more info
PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
transcriptionally active chromatin IMP
Inferred from Mutant Phenotype
more info
PubMed 

General protein information

Preferred Names
exosome component 10
Names
P100 polymyositis-scleroderma overlap syndrome-associated autoantigen
autoantigen PM-SCL
polymyositis/scleroderma autoantigen 100 kDa
polymyositis/scleroderma autoantigen 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001001998.3NP_001001998.1  exosome component 10 isoform 1

    See identical proteins and their annotated locations for NP_001001998.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BC028687, BC073788, CA307576
    Consensus CDS
    CCDS30584.1
    UniProtKB/Swiss-Prot
    Q01780
    Related
    ENSP00000366135.4, ENST00000376936.8
    Conserved Domains (3) summary
    cd06147
    Location:284474
    Rrp6p_like_exo; DEDDy 3'-5' exonuclease domain of yeast Rrp6p, human polymyositis/scleroderma autoantigen 100kDa, and similar proteins
    smart00341
    Location:503583
    HRDC; Helicase and RNase D C-terminal
    pfam08066
    Location:46132
    PMC2NT; PMC2NT (NUC016) domain
  2. NM_002685.3NP_002676.1  exosome component 10 isoform 2

    See identical proteins and their annotated locations for NP_002676.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    BC028687, BC073788, CA307576, DA505395, L01457
    Consensus CDS
    CCDS126.1
    UniProtKB/Swiss-Prot
    Q01780
    Related
    ENSP00000307307.7, ENST00000304457.11
    Conserved Domains (3) summary
    cd06147
    Location:284474
    Rrp6p_like_exo; DEDDy 3'-5' exonuclease domain of yeast Rrp6p, human polymyositis/scleroderma autoantigen 100kDa, and similar proteins
    smart00341
    Location:503583
    HRDC; Helicase and RNase D C-terminal
    pfam08066
    Location:46132
    PMC2NT; PMC2NT (NUC016) domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    11066613..11099910 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005263475.2XP_005263532.2  exosome component 10 isoform X1

    Conserved Domains (3) summary
    cd06147
    Location:284474
    Rrp6p_like_exo; DEDDy 3'-5' exonuclease domain of yeast Rrp6p, human polymyositis/scleroderma autoantigen 100kDa, and similar proteins
    smart00341
    Location:503583
    HRDC; Helicase and RNase D C-terminal
    pfam08066
    Location:46132
    PMC2NT; PMC2NT (NUC016) domain
  2. XM_017001497.2XP_016856986.1  exosome component 10 isoform X3

  3. XM_017001495.2XP_016856984.1  exosome component 10 isoform X2

RNA

  1. XR_002956819.1 RNA Sequence

  2. XR_002956818.1 RNA Sequence

  3. XR_002956822.1 RNA Sequence

  4. XR_002956821.1 RNA Sequence

  5. XR_002956820.1 RNA Sequence

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