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EXOSC10 exosome component 10 [ Homo sapiens (human) ]

Gene ID: 5394, updated on 8-Jan-2023

Summary

Official Symbol
EXOSC10provided by HGNC
Official Full Name
exosome component 10provided by HGNC
Primary source
HGNC:HGNC:9138
See related
Ensembl:ENSG00000171824 MIM:605960; AllianceGenome:HGNC:9138
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
p2; p3; p4; RRP6; PMSCL; Rrp6p; PM-Scl; PMSCL2; PM/Scl-100
Summary
Enables 3'-5'-exoribonuclease activity. Involved in several processes, including RNA catabolic process; maturation of 5.8S rRNA; and negative regulation of telomere maintenance via telomerase. Located in cytosol; nuclear lumen; and transcriptionally active chromatin. Part of nuclear exosome (RNase complex). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in skin (RPKM 18.4), testis (RPKM 18.0) and 25 other tissues See more
Orthologs
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Genomic context

See EXOSC10 in Genome Data Viewer
Location:
1p36.22
Exon count:
26
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (11066618..11099869, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (10608183..10641440, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (11126675..11159926, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene TAR DNA binding protein Neighboring gene MBL associated serine protease 2 Neighboring gene spermidine synthase Neighboring gene EXOSC10 antisense RNA 1 Neighboring gene mechanistic target of rapamycin kinase Neighboring gene MTOR antisense RNA 1 Neighboring gene RNA, U6 small nuclear 537, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of exosome component 10 (EXOSC10) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag Interaction of HIV-1 Gag with exosome component 10 (EXOSC10) is identified in a series of six affinity purification/mass spectrometry screens PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 3'-5'-RNA exonuclease activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables 3'-5'-RNA exonuclease activity TAS
Traceable Author Statement
more info
 
enables RNA binding HDA PubMed 
enables exoribonuclease activity IDA
Inferred from Direct Assay
more info
PubMed 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables single-stranded RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables telomerase RNA binding IC
Inferred by Curator
more info
PubMed 
Process Evidence Code Pubs
involved_in CUT catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in RNA catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in RNA processing IDA
Inferred from Direct Assay
more info
PubMed 
involved_in dosage compensation by inactivation of X chromosome IEA
Inferred from Electronic Annotation
more info
 
involved_in exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in histone mRNA catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in histone mRNA catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in maturation of 5.8S rRNA IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of telomere maintenance via telomerase IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in nuclear mRNA surveillance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in nuclear polyadenylation-dependent CUT catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in nuclear polyadenylation-dependent antisense transcript catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in nuclear polyadenylation-dependent rRNA catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in nuclear polyadenylation-dependent rRNA catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in nuclear polyadenylation-dependent snRNA catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in nuclear polyadenylation-dependent snoRNA catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in nuclear polyadenylation-dependent tRNA catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in nuclear-transcribed mRNA catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IEA
Inferred from Electronic Annotation
more info
 
involved_in polyadenylation-dependent snoRNA 3'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in rRNA processing TAS
Traceable Author Statement
more info
 
involved_in regulation of telomerase RNA localization to Cajal body IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
part_of cytoplasmic exosome (RNase complex) NAS
Non-traceable Author Statement
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in euchromatin IMP
Inferred from Mutant Phenotype
more info
PubMed 
part_of exosome (RNase complex) IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane HDA PubMed 
part_of nuclear exosome (RNase complex) IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of nuclear exosome (RNase complex) IDA
Inferred from Direct Assay
more info
PubMed 
part_of nuclear exosome (RNase complex) NAS
Non-traceable Author Statement
more info
PubMed 
part_of nucleolar exosome (RNase complex) NAS
Non-traceable Author Statement
more info
PubMed 
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
exosome component 10
Names
P100 polymyositis-scleroderma overlap syndrome-associated autoantigen
autoantigen PM-SCL
polymyositis/scleroderma autoantigen 100 kDa
polymyositis/scleroderma autoantigen 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001001998.3NP_001001998.1  exosome component 10 isoform 1

    See identical proteins and their annotated locations for NP_001001998.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BC028687, BC073788, CA307576
    Consensus CDS
    CCDS30584.1
    UniProtKB/Swiss-Prot
    Q01780, Q15158
    Related
    ENSP00000366135.4, ENST00000376936.9
    Conserved Domains (3) summary
    cd06147
    Location:284474
    Rrp6p_like_exo; DEDDy 3'-5' exonuclease domain of yeast Rrp6p, human polymyositis/scleroderma autoantigen 100kDa, and similar proteins
    smart00341
    Location:503583
    HRDC; Helicase and RNase D C-terminal
    pfam08066
    Location:47133
    PMC2NT; PMC2NT (NUC016) domain
  2. NM_002685.4NP_002676.1  exosome component 10 isoform 2

    See identical proteins and their annotated locations for NP_002676.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    BC028687, BC073788, CA307576, L01457
    Consensus CDS
    CCDS126.1
    UniProtKB/Swiss-Prot
    Q01780
    Related
    ENSP00000307307.7, ENST00000304457.11
    Conserved Domains (3) summary
    cd06147
    Location:284474
    Rrp6p_like_exo; DEDDy 3'-5' exonuclease domain of yeast Rrp6p, human polymyositis/scleroderma autoantigen 100kDa, and similar proteins
    smart00341
    Location:503583
    HRDC; Helicase and RNase D C-terminal
    pfam08066
    Location:46132
    PMC2NT; PMC2NT (NUC016) domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    11066618..11099869 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005263475.3XP_005263532.2  exosome component 10 isoform X1

    Conserved Domains (3) summary
    cd06147
    Location:284474
    Rrp6p_like_exo; DEDDy 3'-5' exonuclease domain of yeast Rrp6p, human polymyositis/scleroderma autoantigen 100kDa, and similar proteins
    smart00341
    Location:503583
    HRDC; Helicase and RNase D C-terminal
    pfam08066
    Location:46132
    PMC2NT; PMC2NT (NUC016) domain
  2. XM_047422661.1XP_047278617.1  exosome component 10 isoform X2

  3. XM_047422663.1XP_047278619.1  exosome component 10 isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    10608183..10641440 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)