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PPIL3 peptidylprolyl isomerase like 3 [ Homo sapiens (human) ]

Gene ID: 53938, updated on 20-Mar-2020

Summary

Official Symbol
PPIL3provided by HGNC
Official Full Name
peptidylprolyl isomerase like 3provided by HGNC
Primary source
HGNC:HGNC:9262
See related
Ensembl:ENSG00000240344 MIM:615811
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CYPJ
Summary
This gene encodes a member of the cyclophilin family. Cyclophilins catalyze the cis-trans isomerization of peptidylprolyl imide bonds in oligopeptides. They have been proposed to act either as catalysts or as molecular chaperones in protein-folding events. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2008]
Expression
Ubiquitous expression in lymph node (RPKM 8.6), ovary (RPKM 7.0) and 25 other tissues See more
Orthologs

Genomic context

See PPIL3 in Genome Data Viewer
Location:
2q33.1
Exon count:
11
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (200870907..200889333, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (201735630..201754048, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene RNA, 5S ribosomal pseudogene 115 Neighboring gene CDC like kinase 1 Neighboring gene RNA, U6 small nuclear 312, pseudogene Neighboring gene NGG1 interacting factor 3 like 1 Neighboring gene RNA, U6 small nuclear 762, pseudogene Neighboring gene origin recognition complex subunit 2 Neighboring gene uncharacterized LOC105373835

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
peptidyl-prolyl cis-trans isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
mRNA splicing, via spliceosome IC
Inferred by Curator
more info
PubMed 
protein folding IEA
Inferred from Electronic Annotation
more info
 
protein peptidyl-prolyl isomerization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
catalytic step 2 spliceosome IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
peptidyl-prolyl cis-trans isomerase-like 3
Names
PPIase
PPIase-like protein 3
cyclophilin J
cyclophilin-like protein 3
cyclophilin-like protein PPIL3
peptidylprolyl cis-trans isomerase-like protein 3
peptidylprolyl isomerase (cyclophilin)-like 3
rotamase PPIL3
NP_115861.1
NP_570981.1
XP_005246708.1
XP_005246709.1
XP_011509660.1
XP_016859841.1
XP_016859842.1
XP_016859843.1
XP_016859844.1
XP_016859845.1
XP_016859846.1
XP_016859847.1
XP_016859848.1
XP_016859849.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032472.4NP_115861.1  peptidyl-prolyl cis-trans isomerase-like 3 isoform PPIL3a

    See identical proteins and their annotated locations for NP_115861.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (PPIL3a) encodes the longer isoform (PPIL3a).
    Source sequence(s)
    AC005037, AF251049, AF271652
    Consensus CDS
    CCDS2332.1
    UniProtKB/Swiss-Prot
    Q9H2H8
    UniProtKB/TrEMBL
    A0A0S2Z5A8
    Related
    ENSP00000286175.8, ENST00000286175.12
    Conserved Domains (1) summary
    cl00197
    Location:1158
    cyclophilin; cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the ...
  2. NM_130906.3NP_570981.1  peptidyl-prolyl cis-trans isomerase-like 3 isoform PPIL3b

    See identical proteins and their annotated locations for NP_570981.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (PPIL3b) includes an alternate in-frame segment, compared to variant PPIL3a, resulting in a shorter protein (isoform PPIL3b), compared to isoform PPIL3a. Variants PPIL3b and PPIL3c encode the same protein.
    Source sequence(s)
    AC005037, AF271652, CB961908
    Consensus CDS
    CCDS2333.1
    UniProtKB/Swiss-Prot
    Q9H2H8
    UniProtKB/TrEMBL
    A0A024R3V4
    Related
    ENSP00000376107.4, ENST00000392283.9
    Conserved Domains (1) summary
    cd01928
    Location:1154
    Cyclophilin_PPIL3_like; Proteins similar to Human cyclophilin-like peptidylprolyl cis- trans isomerase (PPIL3). Members of this family lack a key residue important for cyclosporin binding: the tryptophan residue corresponding to W121 in human hCyP-18a; most members have a ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    200870907..200889333 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005246651.3XP_005246708.1  peptidyl-prolyl cis-trans isomerase-like 3 isoform X1

    See identical proteins and their annotated locations for XP_005246708.1

    UniProtKB/Swiss-Prot
    Q9H2H8
    UniProtKB/TrEMBL
    A0A0S2Z5A8
    Related
    ENSP00000387012.1, ENST00000409449.5
    Conserved Domains (1) summary
    cl00197
    Location:1158
    cyclophilin; cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the ...
  2. XM_017004358.1XP_016859847.1  peptidyl-prolyl cis-trans isomerase-like 3 isoform X3

  3. XM_017004352.1XP_016859841.1  peptidyl-prolyl cis-trans isomerase-like 3 isoform X1

    UniProtKB/Swiss-Prot
    Q9H2H8
    UniProtKB/TrEMBL
    A0A0S2Z5A8
    Related
    ENSP00000386235.1, ENST00000409361.5
    Conserved Domains (1) summary
    cl00197
    Location:1158
    cyclophilin; cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the ...
  4. XM_011511358.2XP_011509660.1  peptidyl-prolyl cis-trans isomerase-like 3 isoform X2

    See identical proteins and their annotated locations for XP_011509660.1

    UniProtKB/Swiss-Prot
    Q9H2H8
    UniProtKB/TrEMBL
    A0A024R3V4
    Related
    ENST00000465823.5
    Conserved Domains (1) summary
    cd01928
    Location:1154
    Cyclophilin_PPIL3_like; Proteins similar to Human cyclophilin-like peptidylprolyl cis- trans isomerase (PPIL3). Members of this family lack a key residue important for cyclosporin binding: the tryptophan residue corresponding to W121 in human hCyP-18a; most members have a ...
  5. XM_017004357.1XP_016859846.1  peptidyl-prolyl cis-trans isomerase-like 3 isoform X3

  6. XM_017004359.1XP_016859848.1  peptidyl-prolyl cis-trans isomerase-like 3 isoform X3

  7. XM_017004360.1XP_016859849.1  peptidyl-prolyl cis-trans isomerase-like 3 isoform X3

  8. XM_017004355.2XP_016859844.1  peptidyl-prolyl cis-trans isomerase-like 3 isoform X2

    UniProtKB/Swiss-Prot
    Q9H2H8
    UniProtKB/TrEMBL
    A0A024R3V4
    Conserved Domains (1) summary
    cd01928
    Location:1154
    Cyclophilin_PPIL3_like; Proteins similar to Human cyclophilin-like peptidylprolyl cis- trans isomerase (PPIL3). Members of this family lack a key residue important for cyclosporin binding: the tryptophan residue corresponding to W121 in human hCyP-18a; most members have a ...
  9. XM_017004356.2XP_016859845.1  peptidyl-prolyl cis-trans isomerase-like 3 isoform X2

    UniProtKB/Swiss-Prot
    Q9H2H8
    UniProtKB/TrEMBL
    A0A024R3V4
    Conserved Domains (1) summary
    cd01928
    Location:1154
    Cyclophilin_PPIL3_like; Proteins similar to Human cyclophilin-like peptidylprolyl cis- trans isomerase (PPIL3). Members of this family lack a key residue important for cyclosporin binding: the tryptophan residue corresponding to W121 in human hCyP-18a; most members have a ...
  10. XM_017004354.2XP_016859843.1  peptidyl-prolyl cis-trans isomerase-like 3 isoform X1

    UniProtKB/Swiss-Prot
    Q9H2H8
    UniProtKB/TrEMBL
    A0A0S2Z5A8
    Conserved Domains (1) summary
    cl00197
    Location:1158
    cyclophilin; cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the ...
  11. XM_017004353.1XP_016859842.1  peptidyl-prolyl cis-trans isomerase-like 3 isoform X1

    UniProtKB/Swiss-Prot
    Q9H2H8
    UniProtKB/TrEMBL
    A0A0S2Z5A8
    Conserved Domains (1) summary
    cl00197
    Location:1158
    cyclophilin; cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the ...
  12. XM_005246652.5XP_005246709.1  peptidyl-prolyl cis-trans isomerase-like 3 isoform X2

    See identical proteins and their annotated locations for XP_005246709.1

    UniProtKB/Swiss-Prot
    Q9H2H8
    UniProtKB/TrEMBL
    A0A024R3V4
    Conserved Domains (1) summary
    cd01928
    Location:1154
    Cyclophilin_PPIL3_like; Proteins similar to Human cyclophilin-like peptidylprolyl cis- trans isomerase (PPIL3). Members of this family lack a key residue important for cyclosporin binding: the tryptophan residue corresponding to W121 in human hCyP-18a; most members have a ...

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_131916.1: Suppressed sequence

    Description
    NM_131916.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript, which aligns with non-consensus splice sites in the 5' UTR.
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