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PLAG1 PLAG1 zinc finger [ Bos taurus (domestic cattle) ]

Gene ID: 539210, updated on 5-Aug-2026
Official Symbol
PLAG1provided by VGNC
Official Full Name
PLAG1 zinc fingerprovided by VGNC
Primary source
VGNC:VGNC:32971
See related
BGD:BT22546; Ensembl:ENSBTAG00070022683
Gene type
protein coding
RefSeq status
MODEL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
all
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Try the new Transcripts and proteins table
See PLAG1 in Genome Data Viewer
Location:
chromosome: 14
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 14 NC_037341.1 (23323709..23375679, complement)

Chromosome 14 - NC_037341.1Genomic Context describing neighboring genes Neighboring gene U1 spliceosomal RNA Neighboring gene MOS proto-oncogene, serine/threonine kinase Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 7 Neighboring gene short chain dehydrogenase/reductase family 16C member 5

Genomic Sequence:
NC_037341.1 Chromosome 14 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. A SNP in PLAG1 is associated with body height trait in Chinese cattle. Hou J, et al. Anim Genet, 2020 Feb. PMID 31643102
  2. The PLAG1 mRNA expression analysis among genetic variants and relevance to growth traits in Chinese cattle. Li Z, et al. Anim Biotechnol, 2020 Dec. PMID 31253059
  3. Detection of 19-bp deletion within PLAG1 gene and its effect on growth traits in cattle. Xu W, et al. Gene, 2018 Oct 30. PMID 29913240
  4. A PLAG1 mutation contributed to stature recovery in modern cattle. Utsunomiya YT, et al. Sci Rep, 2017 Dec 7. PMID 29215042, Free PMC Article
  5. Genome-Wide Association Study Reveals the PLAG1 Gene for Knuckle, Biceps and Shank Weight in Simmental Beef Cattle. Song Y, et al. PLoS One, 2016. PMID 27997562, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The PLAG1 mRNA expression analysis among genetic variants and relevance to growth traits in Chinese cattle.
    Title: The PLAG1 mRNA expression analysis among genetic variants and relevance to growth traits in Chinese cattle.
  2. the SNP rs109815800 in PLAG1 strongly influences body height in Chinese cattle
    Title: A SNP in PLAG1 is associated with body height trait in Chinese cattle.
  3. found evidence that the bovine PLAG1 mutation (Q) with major effects on body size, weight and reproduction is a >1,000 years old derived allele that increased rapidly in frequency in Northwestern European B. taurus between the 16(th) and 18(th) centuries
    Title: A PLAG1 mutation contributed to stature recovery in modern cattle.
  4. The selection of PLAG1 gene could be used to ensure the breeding direction for growth traits of the beef cattle.
    Title: A novel SNP of PLAG1 gene and its association with growth traits in Chinese cattle.
  5. The Indel marker of PLAG1 gene can be used as candidate molecular markers for the breeding in cattle.
    Title: Detection of 19-bp deletion within PLAG1 gene and its effect on growth traits in cattle.
  6. Genome-Wide Association Study Reveals the PLAG1 Gene for Knuckle, Biceps and Shank Weight in Simmental Beef Cattle.
    Title: Genome-Wide Association Study Reveals the PLAG1 Gene for Knuckle, Biceps and Shank Weight in Simmental Beef Cattle.
  7. A region of reduced heterozygosity surrounds the C allele; this is small in B. taurus but 20 Mb long in Brahmans, indicating recent and strong selection for the mutant allele.
    Title: Evidence for pleiotropism and recent selection in the PLAG1 region in Australian Beef cattle.
  8. Its genetic variation influences body weight gain and body size of cattle.
    Title: Comparison of the effects explained by variations in the bovine PLAG1 and NCAPG genes on daily body weight gain, linear skeletal measurements and carcass traits in Japanese Black steers from a progeny testing program.
  9. This study demonstrates a strong association of early life body weight with pleiomorphic adenoma gene 1 (PLAG1) genotype in Holstein-Friesian dairy calves. Peripubertal body weight and growth rate were also significantly associated with PLAG1 genotype.
    Title: Genetic variation in PLAG1 associates with early life body weight and peripubertal weight and growth in Bos taurus.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
zinc finger protein PLAG1
Names
pleiomorphic adenoma gene 1

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037341.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    23323709..23375679 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005215434.4 → XP_005215491.1  zinc finger protein PLAG1 isoform X2

    See identical proteins and their annotated locations for XP_005215491.1

    Conserved Domains (4) summary
    COG5236
    Location:39 → 154
    COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    sd00017
    Location:70 → 90
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:10 → 32
    zf-C2H2; Zinc finger, C2H2 type
    cd20908
    Location:10 → 58
    SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins

  2. XM_005215432.4 → XP_005215489.1  zinc finger protein PLAG1 isoform X1

    See identical proteins and their annotated locations for XP_005215489.1

    UniProtKB/TrEMBL
    E1BEA5
    Related
    ENSBTAP00070030500.1, ENSBTAT00070051090.1
    Conserved Domains (4) summary
    COG5189
    Location:58 → 139
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    COG5236
    Location:121 → 236
    COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    sd00017
    Location:36 → 56
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:79 → 103
    zf-H2C2_2; Zinc-finger double domain
Nucleotide Protein Strain
Heading Accession and Version

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