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PELO pelota mRNA surveillance and ribosome rescue factor [ Homo sapiens (human) ]

Gene ID: 53918, updated on 1-Jun-2020

Summary

Official Symbol
PELOprovided by HGNC
Official Full Name
pelota mRNA surveillance and ribosome rescue factorprovided by HGNC
Primary source
HGNC:HGNC:8829
See related
Ensembl:ENSG00000152684 MIM:605757
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CGI-17; PRO1770
Summary
This gene encodes a protein which contains a conserved nuclear localization signal. The encoded protein may have a role in spermatogenesis, cell cycle control, and in meiotic cell division. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in adrenal (RPKM 14.2), spleen (RPKM 12.3) and 25 other tissues See more
Orthologs

Genomic context

See PELO in Genome Data Viewer
Location:
5q11.2
Exon count:
3
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (52787916..52804044)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (52083774..52098451)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378963 Neighboring gene uncharacterized LOC105378964 Neighboring gene integrin subunit alpha 1 Neighboring gene B3GNTL1 pseudogene 1 Neighboring gene ribosomal protein L17 pseudogene 21

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
NHGRI GWA Catalog
Genome-wide association study of antiphospholipid antibodies.
NHGRI GWA Catalog
Polymorphic markers associated with severe oxaliplatin-induced, chronic peripheral neuropathy in colon cancer patients.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Pol gag-pol HIV-1 Pol is identified to have a physical interaction with pelota homolog (PELO) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
endonuclease activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ribosome binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
RNA surveillance IEA
Inferred from Electronic Annotation
more info
 
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
chromosome organization IEA
Inferred from Electronic Annotation
more info
 
endoderm development IEA
Inferred from Electronic Annotation
more info
 
inner cell mass cell proliferation IEA
Inferred from Electronic Annotation
more info
 
mesenchymal to epithelial transition IEA
Inferred from Electronic Annotation
more info
 
nonfunctional rRNA decay IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear-transcribed mRNA catabolic process, no-go decay IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear-transcribed mRNA catabolic process, non-stop decay IEA
Inferred from Electronic Annotation
more info
 
nucleic acid phosphodiester bond hydrolysis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of BMP signaling pathway IEA
Inferred from Electronic Annotation
more info
 
ribosome disassembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
stem cell population maintenance IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
protein pelota homolog
Names
pelota homolog

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015946.5NP_057030.3  protein pelota homolog

    See identical proteins and their annotated locations for NP_057030.3

    Status: REVIEWED

    Source sequence(s)
    AC026230
    Consensus CDS
    CCDS3956.1
    UniProtKB/Swiss-Prot
    Q9BRX2
    Related
    ENSP00000274311.2, ENST00000274311.3
    Conserved Domains (4) summary
    COG1537
    Location:1371
    PelA; Stalled ribosome rescue protein Dom34, pelota family [Translation, ribosomal structure and biogenesis]
    pfam03463
    Location:1128
    eRF1_1; eRF1 domain 1
    pfam03464
    Location:136268
    eRF1_2; eRF1 domain 2
    pfam03465
    Location:271370
    eRF1_3; eRF1 domain 3

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    52787916..52804044
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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