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RAB24 RAB24, member RAS oncogene family [ Homo sapiens (human) ]

Gene ID: 53917, updated on 23-Nov-2021

Summary

Official Symbol
RAB24provided by HGNC
Official Full Name
RAB24, member RAS oncogene familyprovided by HGNC
Primary source
HGNC:HGNC:9765
See related
Ensembl:ENSG00000169228 MIM:612415
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
RAB24 is a small GTPase of the Rab subfamily of Ras-related proteins that regulate intracellular protein trafficking (Olkkonen et al., 1993 [PubMed 8126105]).[supplied by OMIM, Aug 2009]
Expression
Ubiquitous expression in spleen (RPKM 20.5), appendix (RPKM 14.7) and 25 other tissues See more
Orthologs
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Genomic context

See RAB24 in Genome Data Viewer
Location:
5q35.3
Exon count:
7
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (177301198..177303719, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (176728199..176730720, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene nuclear receptor binding SET domain protein 1 Neighboring gene ribosomal protein L21 pseudogene 60 Neighboring gene protein arginine methyltransferase 1 pseudogene 1 Neighboring gene Sharpr-MPRA regulatory region 13731 Neighboring gene PRELI domain containing 1 Neighboring gene MAX dimerization protein 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: MXD3

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in autophagy IEA
Inferred from Electronic Annotation
more info
 
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in autophagosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
is_active_in endocytic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in secretory granule membrane TAS
Traceable Author Statement
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001031677.4NP_001026847.1  ras-related protein Rab-24

    See identical proteins and their annotated locations for NP_001026847.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the functional protein. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AF087904, AI868941, AV698158, BC021263, DA898352
    Consensus CDS
    CCDS34300.1
    UniProtKB/Swiss-Prot
    Q969Q5
    Related
    ENSP00000304376.6, ENST00000303251.11
    Conserved Domains (1) summary
    cd04118
    Location:8201
    Rab24; Rab GTPase family 24 (Rab24)
  2. NM_130781.4NP_570137.2  ras-related protein Rab-24

    See identical proteins and their annotated locations for NP_570137.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AF087904, AI868941, AV698158, BC015534, DA898352
    Consensus CDS
    CCDS34300.1
    UniProtKB/Swiss-Prot
    Q969Q5
    Related
    ENSP00000377235.2, ENST00000393611.6
    Conserved Domains (1) summary
    cd04118
    Location:8201
    Rab24; Rab GTPase family 24 (Rab24)

RNA

  1. NR_109789.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks a segment in the 5' region, and includes an additional internal segment, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AF087904, AF258583, AI868941, AK308155, AV698158, DA898352
  2. NR_109790.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) includes an additional internal segment, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AF087904, AF258583, AI868941, AV698158, DA058886
    Related
    ENST00000478234.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    177301198..177303719 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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