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Rcan2 regulator of calcineurin 2 [ Mus musculus (house mouse) ]

Gene ID: 53901, updated on 5-Mar-2024

Summary

Official Symbol
Rcan2provided by MGI
Official Full Name
regulator of calcineurin 2provided by MGI
Primary source
MGI:MGI:1858219
See related
Ensembl:ENSMUSG00000039601 AllianceGenome:MGI:1858219
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Csp2; MCIP2; ZAKI-4; Dscr1l1
Summary
Predicted to enable calcium-dependent protein serine/threonine phosphatase regulator activity. Acts upstream of or within several processes, including calcineurin-NFAT signaling cascade; locomotion involved in locomotory behavior; and short-term memory. Predicted to be active in cytoplasm and nucleus. Is expressed in central nervous system; heart; and retina. Orthologous to human RCAN2 (regulator of calcineurin 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in heart adult (RPKM 48.9), cerebellum adult (RPKM 27.1) and 8 other tissues See more
Orthologs
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Genomic context

See Rcan2 in Genome Data Viewer
Location:
17 B3; 17 19.77 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (44112243..44350407)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (43801352..44039516)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene cytochrome P450, family 39, subfamily a, polypeptide 1 Neighboring gene predicted gene, 41581 Neighboring gene predicted gene, 34773 Neighboring gene STARR-seq mESC enhancer starr_42606 Neighboring gene STARR-seq mESC enhancer starr_42607 Neighboring gene predicted gene, 34857 Neighboring gene ectonucleotide pyrophosphatase/phosphodiesterase 5

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (5) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium-dependent protein serine/threonine phosphatase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
calcipressin-2
Names
Down syndrome critical region gene 1-like 1
calcineurin inhibitory protein ZAKI-4
down syndrome candidate region 1-like protein 1
myocyte-enriched calcineurin interactin protein 2
myocyte-enriched calcineurin-interacting protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286653.1NP_001273582.1  calcipressin-2 isoform 1

    See identical proteins and their annotated locations for NP_001273582.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has an alternate 5' UTR exon, compared to variant 1. Variants 1, 3 and 5 encode the same isoform (1).
    Source sequence(s)
    AC154204, CT025668
    Consensus CDS
    CCDS28800.1
    UniProtKB/TrEMBL
    A0A2R8W6E8, Q8VIP4
    Related
    ENSMUSP00000039473.6, ENSMUST00000044895.13
    Conserved Domains (1) summary
    pfam04847
    Location:80236
    Calcipressin; Calcipressin
  2. NM_001286654.1NP_001273583.1  calcipressin-2 isoform 2

    See identical proteins and their annotated locations for NP_001273583.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and 5' coding region, compared to variant 1. The resultign isoform (2) has a shorter and distinct N-terminus, compared to isoform 1. Variants 2 and 4 encode the same isoform 2.
    Source sequence(s)
    CT025668
    Consensus CDS
    CCDS28801.1
    UniProtKB/Swiss-Prot
    Q8VIP5, Q9JHG2
    UniProtKB/TrEMBL
    Q543P2
    Related
    ENSMUSP00000137211.2, ENSMUST00000177857.9
    Conserved Domains (1) summary
    pfam04847
    Location:22190
    Calcipressin
  3. NM_001357742.1NP_001344671.1  calcipressin-2 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1, 3 and 5 encode the same isoform (1).
    Source sequence(s)
    AC154204, BC049096, CT025668
    Consensus CDS
    CCDS28800.1
    UniProtKB/TrEMBL
    A0A2R8W6E8, Q8VIP4
    Related
    ENSMUSP00000154835.2, ENSMUST00000228972.2
    Conserved Domains (1) summary
    pfam04847
    Location:80236
    Calcipressin; Calcipressin
  4. NM_030598.2NP_085101.1  calcipressin-2 isoform 2

    See identical proteins and their annotated locations for NP_085101.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus, compared to isoform 1. Variants 2 and 4 encode the same isoform 2.
    Source sequence(s)
    BC049096
    Consensus CDS
    CCDS28801.1
    UniProtKB/Swiss-Prot
    Q8VIP5, Q9JHG2
    UniProtKB/TrEMBL
    Q543P2
    Related
    ENSMUSP00000048013.5, ENSMUST00000044792.6
    Conserved Domains (1) summary
    pfam04847
    Location:22190
    Calcipressin
  5. NM_207649.1NP_997532.1  calcipressin-2 isoform 1

    See identical proteins and their annotated locations for NP_997532.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1). Variants 1, 3 and 5 encode the same isoform (1).
    Source sequence(s)
    BB635249, BC049096, BY740155
    Consensus CDS
    CCDS28800.1
    UniProtKB/TrEMBL
    A0A2R8W6E8, Q8VIP4
    Related
    ENSMUSP00000155082.2, ENSMUST00000229744.2
    Conserved Domains (1) summary
    pfam04847
    Location:80236
    Calcipressin; Calcipressin

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    44112243..44350407
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)