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PAN2 poly(A) specific ribonuclease subunit PAN2 [ Bos taurus (cattle) ]

Gene ID: 538820, updated on 6-Jun-2024

Summary

Official Symbol
PAN2provided by VGNC
Official Full Name
poly(A) specific ribonuclease subunit PAN2provided by VGNC
Primary source
VGNC:VGNC:58444
See related
BGD:BT17832; Ensembl:ENSBTAG00000004376
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
USP52
Orthologs
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Genomic context

See PAN2 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 5 NC_037332.1 (57014982..57028884)

Chromosome 5 - NC_037332.1Genomic Context describing neighboring genes Neighboring gene signal transducer and activator of transcription 2 Neighboring gene interleukin 23 subunit alpha Neighboring gene microRNA mir-2432 Neighboring gene transfer RNA glutamic acid (anticodon UUC) Neighboring gene microRNA mir-12054 Neighboring gene canopy FGF signaling regulator 2 Neighboring gene citrate synthase

Genomic regions, transcripts, and products

Genomic Sequence:
NC_037332.1 Chromosome 5 Reference ARS-UCD2.0 Primary Assembly

General gene information

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
PubMed 
enables poly(A)-specific ribonuclease activity IEA
Inferred from Electronic Annotation
more info
PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
PubMed 
Process Evidence Code Pubs
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
PubMed 
involved_in nuclear-transcribed mRNA poly(A) tail shortening IEA
Inferred from Electronic Annotation
more info
PubMed 
Component Evidence Code Pubs
located_in P-body IEA
Inferred from Electronic Annotation
more info
PubMed 
part_of PAN complex IEA
Inferred from Electronic Annotation
more info
PubMed 

General protein information

Preferred Names
PAN2-PAN3 deadenylation complex catalytic subunit PAN2
Names
PAN2 poly(A) specific ribonuclease subunit homolog
PAN2 polyA specific ribonuclease subunit homolog
ubiquitin specific peptidase 52
ubiquitin specific protease 52
NP_001073078.2
XP_005206705.1
XP_015326604.1
XP_024847764.1
XP_059742582.1
XP_059742583.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001079610.2NP_001073078.2  PAN2-PAN3 deadenylation complex catalytic subunit PAN2

    See identical proteins and their annotated locations for NP_001073078.2

    Status: VALIDATED

    Source sequence(s)
    NKLS02000005
    UniProtKB/TrEMBL
    E1BML0
    Related
    ENSBTAP00000053637.3, ENSBTAT00000061314.4
    Conserved Domains (3) summary
    cd06143
    Location:9711144
    PAN2_exo; DEDDh 3'-5' exonuclease domain of the eukaryotic exoribonuclease PAN2
    cd02672
    Location:502917
    Peptidase_C19P; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cl25539
    Location:204357
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037332.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    57014982..57028884
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015471118.3XP_015326604.1  PAN2-PAN3 deadenylation complex catalytic subunit PAN2 isoform X1

    UniProtKB/TrEMBL
    E1BML0
    Conserved Domains (4) summary
    cd06143
    Location:9741147
    PAN2_exo; DEDDh 3'-5' exonuclease domain of the eukaryotic exoribonuclease PAN2
    cd02672
    Location:502920
    Peptidase_C19P; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam13423
    Location:517897
    UCH_1; Ubiquitin carboxyl-terminal hydrolase
    cl02567
    Location:204357
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  2. XM_024991996.2XP_024847764.1  PAN2-PAN3 deadenylation complex catalytic subunit PAN2 isoform X2

    UniProtKB/TrEMBL
    E1BML0
    Conserved Domains (3) summary
    cd06143
    Location:9731146
    PAN2_exo; DEDDh 3'-5' exonuclease domain of the eukaryotic exoribonuclease PAN2
    cd02672
    Location:502919
    Peptidase_C19P; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cl25539
    Location:204357
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  3. XM_005206648.5XP_005206705.1  PAN2-PAN3 deadenylation complex catalytic subunit PAN2 isoform X3

    UniProtKB/TrEMBL
    E1BML0
    Conserved Domains (3) summary
    cd06143
    Location:9701143
    PAN2_exo; DEDDh 3'-5' exonuclease domain of the eukaryotic exoribonuclease PAN2
    cd02672
    Location:502916
    Peptidase_C19P; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cl25539
    Location:204357
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  4. XM_059886599.1XP_059742582.1  PAN2-PAN3 deadenylation complex catalytic subunit PAN2 isoform X4

    UniProtKB/TrEMBL
    A0AAA9SNV9
  5. XM_059886600.1XP_059742583.1  PAN2-PAN3 deadenylation complex catalytic subunit PAN2 isoform X5

    UniProtKB/TrEMBL
    E1BML0