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Slc5a3 solute carrier family 5 (inositol transporters), member 3 [ Mus musculus (house mouse) ]

Gene ID: 53881, updated on 8-Feb-2024

Summary

Official Symbol
Slc5a3provided by MGI
Official Full Name
solute carrier family 5 (inositol transporters), member 3provided by MGI
Primary source
MGI:MGI:1858226
See related
Ensembl:ENSMUSG00000089774 AllianceGenome:MGI:1858226
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Smit1
Summary
Predicted to enable glucose:sodium symporter activity; potassium channel regulator activity; and transmembrane transporter binding activity. Involved in regulation of transporter activity. Acts upstream of or within several processes, including inositol metabolic process; myo-inositol transport; and positive regulation of reactive oxygen species biosynthetic process. Part of voltage-gated potassium channel complex. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human SLC5A3 (solute carrier family 5 member 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in kidney adult (RPKM 7.8), genital fat pad adult (RPKM 7.5) and 24 other tissues See more
Orthologs
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Genomic context

See Slc5a3 in Genome Data Viewer
Location:
16 C4; 16 53.44 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (91855210..91884361)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (92058322..92087473)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_41494 Neighboring gene predicted gene, 18020 Neighboring gene predicted gene, 23210 Neighboring gene mitochondrial ribosomal protein S6 Neighboring gene STARR-seq mESC enhancer starr_41496 Neighboring gene predicted gene, 41496 Neighboring gene STARR-seq mESC enhancer starr_41498 Neighboring gene STARR-seq mESC enhancer starr_41500 Neighboring gene predicted gene, 41495 Neighboring gene STARR-seq mESC enhancer starr_41501 Neighboring gene STARR-seq mESC enhancer starr_41503 Neighboring gene STARR-seq mESC enhancer starr_41504 Neighboring gene predicted gene, 29880

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables glucose:sodium symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables glucose:sodium symporter activity IEA
Inferred from Electronic Annotation
more info
 
enables myo-inositol:sodium symporter activity ISO
Inferred from Sequence Orthology
more info
 
enables potassium channel regulator activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables symporter activity IEA
Inferred from Electronic Annotation
more info
 
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
enables transmembrane transporter binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in basolateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of voltage-gated potassium channel complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
sodium/myo-inositol cotransporter
Names
Na(+)/myo-inositol cotransporter
sodium myo-inositol transporter 1
solute carrier family 5, member 3
solute carrier family 5, member alpha 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017391.3NP_059087.2  sodium/myo-inositol cotransporter

    See identical proteins and their annotated locations for NP_059087.2

    Status: VALIDATED

    Source sequence(s)
    AC144408, AK144718, BF318171
    Consensus CDS
    CCDS37403.1
    UniProtKB/Swiss-Prot
    B2RU60, Q9JKZ2
    Related
    ENSMUSP00000109608.3, ENSMUST00000113975.3
    Conserved Domains (1) summary
    cd11491
    Location:9718
    SLC5sbd_SMIT; Na(+)/myo-inositol cotransporter SMIT and related proteins; solute-binding domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    91855210..91884361
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)