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Caprin1 cell cycle associated protein 1 [ Mus musculus (house mouse) ]

Gene ID: 53872, updated on 9-Mar-2023

Summary

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Official Symbol
Caprin1provided by MGI
Official Full Name
cell cycle associated protein 1provided by MGI
Primary source
MGI:MGI:1858234
See related
Ensembl:ENSMUSG00000027184 AllianceGenome:MGI:1858234
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
P137; Gpiap; Gpiap1; rng105; Caprin-1; Mmgpip137
Summary
Predicted to enable RNA binding activity. Involved in positive regulation of dendritic spine morphogenesis. Located in cytoplasmic stress granule and synapse. Is expressed in central nervous system; eye; and male reproductive system. Orthologous to human CAPRIN1 (cell cycle associated protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 53.6), whole brain E14.5 (RPKM 41.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Caprin1 in Genome Data Viewer
Location:
2; 2 E2
Exon count:
20
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (103593290..103628014, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (103762945..103797669, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene catalase Neighboring gene RIKEN cDNA 8030431J09 gene Neighboring gene ankyrin repeat and BTB (POZ) domain containing 2 Neighboring gene VISTA enhancer mm1312 Neighboring gene N-acetyltransferase 10 Neighboring gene RIKEN cDNA 4930547E08 gene Neighboring gene predicted gene 13880

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Targeted deletion of the RNA-binding protein Caprin1 leads to progressive hearing loss and impairs recovery from noise exposure in mice. Nolan LS, et al. Sci Rep, 2022 Feb 14. PMID 35165318, Free PMC Article
  2. RNG105/caprin1, an RNA granule protein for dendritic mRNA localization, is essential for long-term memory formation. Nakayama K, et al. Elife, 2017 Nov 21. PMID 29157358, Free PMC Article
  3. Comprehensive behavioral analysis of RNG105 (Caprin1) heterozygous mice: Reduced social interaction and attenuated response to novelty. Ohashi R, et al. Sci Rep, 2016 Feb 11. PMID 26865403, Free PMC Article
  4. RNA degradation eliminates developmental transcripts during murine embryonic stem cell differentiation via CAPRIN1-XRN2. Viegas JO, et al. Dev Cell, 2022 Dec 19. PMID 36495875, Free PMC Article
  5. Caprin-1 is a target of the deafness gene Pou4f3 and is recruited to stress granules in cochlear hair cells in response to ototoxic damage. Towers ER, et al. J Cell Sci, 2011 Apr 1. PMID 21402877, Free PMC Article

See all (54) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RNA degradation eliminates developmental transcripts during murine embryonic stem cell differentiation via CAPRIN1-XRN2.
    Title: RNA degradation eliminates developmental transcripts during murine embryonic stem cell differentiation via CAPRIN1-XRN2.
  2. Targeted deletion of the RNA-binding protein Caprin1 leads to progressive hearing loss and impairs recovery from noise exposure in mice.
    Title: Targeted deletion of the RNA-binding protein Caprin1 leads to progressive hearing loss and impairs recovery from noise exposure in mice.
  3. Thus, RNG105 has an essential role, as a key regulator of dendritic mRNA localization, in long-term memory formation.
    Title: RNG105/caprin1, an RNA granule protein for dendritic mRNA localization, is essential for long-term memory formation.
  4. Behavioral analysis of RNG105 heterozygous mice showed reduced social interaction and attenuated response to novelty.
    Title: Comprehensive behavioral analysis of RNG105 (Caprin1) heterozygous mice: Reduced social interaction and attenuated response to novelty.
  5. Fragile mental retardation protein interacts with the RNA-binding protein Caprin1 in neuronal RiboNucleoProtein complexes
    Title: Fragile X mental retardation protein interacts with the RNA-binding protein Caprin1 in neuronal RiboNucleoProtein complexes [corrected].
  6. Stress-granule-associated protein Caprin-1 is downregulated by Pou4f3.
    Title: Caprin-1 is a target of the deafness gene Pou4f3 and is recruited to stress granules in cochlear hair cells in response to ototoxic damage.
  7. The present study first demonstrates the in vivo role of RNG105 in the dendritic localization of mRNAs
    Title: RNG105 deficiency impairs the dendritic localization of mRNAs for Na+/K+ ATPase subunit isoforms and leads to the degeneration of neuronal networks.
  8. Overexpression of a fusion protein of enhanced green fluorescent protein and caprin-1 induces dose-dependent suppression of the proliferation of NIH-3T3 cells, consistent with the notion that caprin-1 plays a role in cellular activation or proliferation.
    Title: Activation/division of lymphocytes results in increased levels of cytoplasmic activation/proliferation-associated protein-1: prototype of a new family of proteins.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables RNA binding ISO
Inferred from Sequence Orthology
more info
  
enables mRNA binding ISO
Inferred from Sequence Orthology
more info
  
enables molecular condensate scaffold activity ISO
Inferred from Sequence Orthology
more info
  
enables signaling adaptor activity ISO
Inferred from Sequence Orthology
more info
  
enables translation regulator activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of translation ISO
Inferred from Sequence Orthology
more info
  
involved_in non-membrane-bounded organelle assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of dendrite morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of dendritic spine morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of deadenylation-dependent decapping of nuclear-transcribed mRNA ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in P-body ISO
Inferred from Sequence Orthology
more info
  
located_in cell leading edge ISO
Inferred from Sequence Orthology
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic stress granule IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasmic stress granule ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
is_active_in intracellular non-membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynapse ISO
Inferred from Sequence Orthology
more info
  
is_active_in synapse EXP
Inferred from Experiment
more info
 PubMed 
is_active_in synapse IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
caprin-1
Names
GPI-anchored membrane protein 1
GPI-anchored protein p137
GPI-p137
RNA granule protein 105
cytoplasmic activation- and proliferation-associated protein 1
cytoplasmic activation/proliferation-associated protein 1
membrane component chromosome 11 surface marker 1
p137GPI

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001111289.2 → NP_001104759.1  caprin-1 isoform a

    See identical proteins and their annotated locations for NP_001104759.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    BX537331
    Consensus CDS
    CCDS16481.1
    UniProtKB/Swiss-Prot
    Q60865, Q7TT26
    Related
    ENSMUSP00000106777.2, ENSMUST00000111147.8
    Conserved Domains (1) summary
    pfam12287
    Location:365 → 677
    Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term

  2. NM_001111290.2 → NP_001104760.1  caprin-1 isoform b

    See identical proteins and their annotated locations for NP_001104760.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate in-frame splice site in the mid-coding region, compared to variant 1. The resulting isoform (b) is shorter than isoform a.
    Source sequence(s)
    BX537331
    UniProtKB/Swiss-Prot
    Q60865
    Conserved Domains (2) summary
    pfam12287
    Location:357 → 670
    Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term
    pfam18293
    Location:130 → 245
    Caprin-1_dimer; Caprin-1 dimerization domain

  3. NM_001111291.2 → NP_001104761.1  caprin-1 isoform c

    See identical proteins and their annotated locations for NP_001104761.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 3' UTR and 3' coding region, compared to variant 1. The resulting isoform (c) has a distinct C-terminus and is shorter than isoform a. Both variants 4 and 5 encode the same isoform.
    Source sequence(s)
    BX537331
    UniProtKB/Swiss-Prot
    Q60865
    Conserved Domains (2) summary
    pfam12287
    Location:357 → 683
    Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term
    pfam18293
    Location:130 → 245
    Caprin-1_dimer; Caprin-1 dimerization domain

  4. NM_001111292.2 → NP_001104762.1  caprin-1 isoform c

    See identical proteins and their annotated locations for NP_001104762.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, 3' UTR and 3' coding region, compared to variant 1. The resulting isoform (c) has a distinct C-terminus and is shorter than isoform a. Both variants 4 and 5 encode the same isoform.
    Source sequence(s)
    BX537331
    UniProtKB/Swiss-Prot
    Q60865
    Conserved Domains (2) summary
    pfam12287
    Location:357 → 683
    Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term
    pfam18293
    Location:130 → 245
    Caprin-1_dimer; Caprin-1 dimerization domain

  5. NM_001412568.1 → NP_001399497.1  caprin-1 isoform d

    Status: VALIDATED

    Source sequence(s)
    BX537331

  6. NM_001412569.1 → NP_001399498.1  caprin-1 isoform d

    Status: VALIDATED

    Source sequence(s)
    BX537331

  7. NM_001412570.1 → NP_001399499.1  caprin-1 isoform e

    Status: VALIDATED

    Source sequence(s)
    BX537331

  8. NM_001412571.1 → NP_001399500.1  caprin-1 isoform e

    Status: VALIDATED

    Source sequence(s)
    BX537331

  9. NM_001412572.1 → NP_001399501.1  caprin-1 isoform b

    Status: VALIDATED

    Source sequence(s)
    BX537331

  10. NM_001412574.1 → NP_001399503.1  caprin-1 isoform f

    Status: VALIDATED

    Source sequence(s)
    BX537331

  11. NM_001412575.1 → NP_001399504.1  caprin-1 isoform g

    Status: VALIDATED

    Source sequence(s)
    BX537331

  12. NM_001412576.1 → NP_001399505.1  caprin-1 isoform h

    Status: VALIDATED

    Source sequence(s)
    BX537331

  13. NM_001412577.1 → NP_001399506.1  caprin-1 isoform i

    Status: VALIDATED

    Source sequence(s)
    BX537331

  14. NM_001412578.1 → NP_001399507.1  caprin-1 isoform i

    Status: VALIDATED

    Source sequence(s)
    BX537331

  15. NM_016739.4 → NP_058019.2  caprin-1 isoform a

    See identical proteins and their annotated locations for NP_058019.2

    Status: VALIDATED

    Source sequence(s)
    BX537331
    Consensus CDS
    CCDS16481.1
    UniProtKB/Swiss-Prot
    Q60865, Q7TT26
    Related
    ENSMUSP00000028607.7, ENSMUST00000028607.13
    Conserved Domains (1) summary
    pfam12287
    Location:365 → 677
    Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    103593290..103628014 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030251880.1 → XP_030107740.1  caprin-1 isoform X1

    Conserved Domains (2) summary
    pfam12287
    Location:278 → 600
    Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term
    pfam18293
    Location:51 → 166
    Caprin-1_dimer; Caprin-1 dimerization domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q60865.2 GenPept UniProtKB/Swiss-Prot:Q60865

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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