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Caprin1 cell cycle associated protein 1 [ Mus musculus (house mouse) ]

Gene ID: 53872, updated on 5-Mar-2024

Summary

Official Symbol
Caprin1provided by MGI
Official Full Name
cell cycle associated protein 1provided by MGI
Primary source
MGI:MGI:1858234
See related
Ensembl:ENSMUSG00000027184 AllianceGenome:MGI:1858234
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
P137; Gpiap; Gpiap1; rng105; Caprin-1; Mmgpip137
Summary
Predicted to enable RNA binding activity. Involved in positive regulation of dendritic spine morphogenesis. Located in cytoplasmic stress granule and synapse. Is expressed in central nervous system; eye; and male reproductive system. Orthologous to human CAPRIN1 (cell cycle associated protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 53.6), whole brain E14.5 (RPKM 41.3) and 28 other tissues See more
Orthologs
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Genomic context

See Caprin1 in Genome Data Viewer
Location:
2 E2; 2 54.43 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (103593292..103627946, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (103762945..103797669, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_05270 Neighboring gene STARR-positive B cell enhancer ABC_E811 Neighboring gene catalase Neighboring gene RIKEN cDNA 8030431J09 gene Neighboring gene STARR-positive B cell enhancer ABC_E7843 Neighboring gene STARR-positive B cell enhancer ABC_E812 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:103408122-103408323 Neighboring gene ankyrin repeat and BTB domain containing 2 Neighboring gene VISTA enhancer mm1312 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:103502331-103502560 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:103522571-103522790 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:103543647-103543756 Neighboring gene STARR-positive B cell enhancer ABC_E11149 Neighboring gene N-acetyltransferase 10 Neighboring gene STARR-positive B cell enhancer ABC_E4483 Neighboring gene STARR-positive B cell enhancer mm9_chr2:103625945-103626245 Neighboring gene STARR-seq mESC enhancer starr_05272 Neighboring gene STARR-seq mESC enhancer starr_05273 Neighboring gene RIKEN cDNA 4930547E08 gene Neighboring gene predicted gene 13880

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA binding ISO
Inferred from Sequence Orthology
more info
 
enables mRNA binding ISO
Inferred from Sequence Orthology
more info
 
enables molecular condensate scaffold activity ISO
Inferred from Sequence Orthology
more info
 
enables molecular function activator activity ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables signaling adaptor activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in P-body ISO
Inferred from Sequence Orthology
more info
 
located_in cell leading edge ISO
Inferred from Sequence Orthology
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic stress granule IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasmic stress granule ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in dendrite IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
is_active_in intracellular non-membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynapse ISO
Inferred from Sequence Orthology
more info
 
is_active_in synapse EXP
Inferred from Experiment
more info
PubMed 
is_active_in synapse IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
caprin-1
Names
GPI-anchored membrane protein 1
GPI-anchored protein p137
GPI-p137
RNA granule protein 105
cytoplasmic activation- and proliferation-associated protein 1
cytoplasmic activation/proliferation-associated protein 1
membrane component chromosome 11 surface marker 1
p137GPI

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001111289.2NP_001104759.1  caprin-1 isoform a

    See identical proteins and their annotated locations for NP_001104759.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    BX537331
    Consensus CDS
    CCDS16481.1
    UniProtKB/Swiss-Prot
    Q60758, Q60865, Q61620, Q6IMN3, Q7TT26
    Related
    ENSMUSP00000106777.2, ENSMUST00000111147.8
    Conserved Domains (1) summary
    pfam12287
    Location:365677
    Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term
  2. NM_001111290.2NP_001104760.1  caprin-1 isoform b

    See identical proteins and their annotated locations for NP_001104760.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate in-frame splice site in the mid-coding region, compared to variant 1. The resulting isoform (b) is shorter than isoform a.
    Source sequence(s)
    BX537331
    UniProtKB/Swiss-Prot
    Q60865
    Conserved Domains (2) summary
    pfam12287
    Location:357670
    Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term
    pfam18293
    Location:130245
    Caprin-1_dimer; Caprin-1 dimerization domain
  3. NM_001111291.2NP_001104761.1  caprin-1 isoform c

    See identical proteins and their annotated locations for NP_001104761.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 3' UTR and 3' coding region, compared to variant 1. The resulting isoform (c) has a distinct C-terminus and is shorter than isoform a. Both variants 4 and 5 encode the same isoform.
    Source sequence(s)
    BX537331
    UniProtKB/Swiss-Prot
    Q60865
    Conserved Domains (2) summary
    pfam12287
    Location:357683
    Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term
    pfam18293
    Location:130245
    Caprin-1_dimer; Caprin-1 dimerization domain
  4. NM_001111292.2NP_001104762.1  caprin-1 isoform c

    See identical proteins and their annotated locations for NP_001104762.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, 3' UTR and 3' coding region, compared to variant 1. The resulting isoform (c) has a distinct C-terminus and is shorter than isoform a. Both variants 4 and 5 encode the same isoform.
    Source sequence(s)
    BX537331
    UniProtKB/Swiss-Prot
    Q60865
    Conserved Domains (2) summary
    pfam12287
    Location:357683
    Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term
    pfam18293
    Location:130245
    Caprin-1_dimer; Caprin-1 dimerization domain
  5. NM_001412568.1NP_001399497.1  caprin-1 isoform d

    Status: VALIDATED

    Source sequence(s)
    BX537331
  6. NM_001412569.1NP_001399498.1  caprin-1 isoform d

    Status: VALIDATED

    Source sequence(s)
    BX537331
  7. NM_001412570.1NP_001399499.1  caprin-1 isoform e

    Status: VALIDATED

    Source sequence(s)
    BX537331
  8. NM_001412571.1NP_001399500.1  caprin-1 isoform e

    Status: VALIDATED

    Source sequence(s)
    BX537331
  9. NM_001412572.1NP_001399501.1  caprin-1 isoform b

    Status: VALIDATED

    Source sequence(s)
    BX537331
  10. NM_001412574.1NP_001399503.1  caprin-1 isoform f

    Status: VALIDATED

    Source sequence(s)
    BX537331
  11. NM_001412575.1NP_001399504.1  caprin-1 isoform g

    Status: VALIDATED

    Source sequence(s)
    BX537331
  12. NM_001412576.1NP_001399505.1  caprin-1 isoform h

    Status: VALIDATED

    Source sequence(s)
    BX537331
  13. NM_001412577.1NP_001399506.1  caprin-1 isoform i

    Status: VALIDATED

    Source sequence(s)
    BX537331
  14. NM_001412578.1NP_001399507.1  caprin-1 isoform i

    Status: VALIDATED

    Source sequence(s)
    BX537331
  15. NM_016739.4NP_058019.2  caprin-1 isoform a

    See identical proteins and their annotated locations for NP_058019.2

    Status: VALIDATED

    Source sequence(s)
    BX537331
    Consensus CDS
    CCDS16481.1
    UniProtKB/Swiss-Prot
    Q60758, Q60865, Q61620, Q6IMN3, Q7TT26
    Related
    ENSMUSP00000028607.7, ENSMUST00000028607.13
    Conserved Domains (1) summary
    pfam12287
    Location:365677
    Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    103593292..103627946 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)