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IRS1 insulin receptor substrate 1 [ Bos taurus (domestic cattle) ]

Gene ID: 538598, updated on 30-Jan-2025
Official Symbol
IRS1provided by VGNC
Official Full Name
insulin receptor substrate 1provided by VGNC
Primary source
VGNC:VGNC:30283
See related
BGD:BT12298; EnsemblRapid:ENSBTAG00070001564
Gene type
protein coding
RefSeq status
MODEL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
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See IRS1 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 2 NC_037329.1 (114928433..114992724, complement)

Chromosome 2 - NC_037329.1Genomic Context describing neighboring genes Neighboring gene large ribosomal subunit protein uL16-like Neighboring gene uncharacterized LOC101902260 Neighboring gene microRNA mir-12053 Neighboring gene large ribosomal subunit protein eL21-like Neighboring gene rhomboid domain containing 1 Neighboring gene collagen type IV alpha 4 chain

Genomic Sequence:
NC_037329.1 Chromosome 2 Reference ARS-UCD2.0 Primary Assembly
  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Markers

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables insulin receptor binding IEA
Inferred from Electronic Annotation
more info
PubMed 
enables phosphatidylinositol 3-kinase binding IEA
Inferred from Electronic Annotation
more info
PubMed 
Process Evidence Code Pubs
involved_in insulin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
PubMed 
Preferred Names
insulin receptor substrate 1

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RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037329.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    114928433..114992724 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_003585773.6XP_003585821.1  insulin receptor substrate 1

    See identical proteins and their annotated locations for XP_003585821.1

    UniProtKB/TrEMBL
    F1MYE0
    Related
    ENSBTAP00070002069.1, ENSBTAT00070003626.1
    Conserved Domains (3) summary
    cd01204
    Location:160263
    PTB_IRS; Insulin receptor substrate phosphotyrosine-binding domain (PTBi)
    cd01257
    Location:11118
    PH_IRS; Insulin receptor substrate (IRS) pleckstrin homology (PH) domain
    pfam00169
    Location:17110
    PH; PH domain