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Map3k14 mitogen-activated protein kinase kinase kinase 14 [ Mus musculus (house mouse) ]

Gene ID: 53859, updated on 7-Apr-2025

Summary

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Official Symbol
Map3k14provided by MGI
Official Full Name
mitogen-activated protein kinase kinase kinase 14provided by MGI
Primary source
MGI:MGI:1858204
See related
Ensembl:ENSMUSG00000020941 AllianceGenome:MGI:1858204
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nik; aly
Summary
Enables protein serine/threonine kinase activity. Involved in immune response and non-canonical NF-kappaB signal transduction. Predicted to be located in cytosol; fibrillar center; and nucleoplasm. Is expressed in several structures, including alimentary system; cardiovascular system; nervous system; sensory organ; and skeleton. Used to study Sjogren's syndrome and primary biliary cholangitis. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human MAP3K14 (mitogen-activated protein kinase kinase kinase 14). [provided by Alliance of Genome Resources, Apr 2025]
Expression
Broad expression in spleen adult (RPKM 11.8), thymus adult (RPKM 8.3) and 23 other tissues See more
Orthologs
human all
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Genomic context

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See Map3k14 in Genome Data Viewer
Location:
11 E1; 11 66.8 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (103110590..103158227, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (103219764..103267401, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene EF-hand calcium binding domain 15 Neighboring gene spermatogenesis associated 32 Neighboring gene predicted gene, 51920 Neighboring gene predicted gene, 34823 Neighboring gene STARR-positive B cell enhancer ABC_E10718 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:103128947-103129269 Neighboring gene STARR-seq mESC enhancer starr_30841 Neighboring gene STARR-seq mESC enhancer starr_30842 Neighboring gene STARR-positive B cell enhancer ABC_E3026 Neighboring gene Rho GTPase activating protein 27 Neighboring gene Rho GTPase activating protein 27, opposite strand 3 Neighboring gene STARR-positive B cell enhancer ABC_E8459 Neighboring gene pleckstrin homology domain containing, family M (with RUN domain) member 1 Neighboring gene STARR-seq mESC enhancer starr_30848 Neighboring gene STARR-positive B cell enhancer ABC_E9376

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. NF-κB-inducing kinase is essential for B-cell maintenance in mice. Hahn M, et al. Eur J Immunol, 2016 Mar. PMID 26593098
  2. Regional variations in the distribution of small intestinal intraepithelial lymphocytes in alymphoplasia (aly/aly) mice and heterozygous (aly/+) mice. Suzuki H, et al. Immunol Invest, 2001 Nov. PMID 11777282
  3. A cell-intrinsic requirement for NF-κB-inducing kinase in CD4 and CD8 T cell memory. Rowe AM, et al. J Immunol, 2013 Oct 1. PMID 24006459, Free PMC Article
  4. Significant involvement of nuclear factor-κB-inducing kinase in proper differentiation of αβ and γδ T cells. Eshima K, et al. Immunology, 2014 Feb. PMID 24117043, Free PMC Article
  5. Uncoupling of glomerular IgA deposition and disease progression in alymphoplasia mice with IgA nephropathy. Aizawa M, et al. PLoS One, 2014. PMID 24743510, Free PMC Article

See all (212) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. NF-kappaB Inducing Kinase Attenuates Colorectal Cancer by Regulating Noncanonical NF-kappaB Mediated Colonic Epithelial Cell Regeneration.
    Title: NF-κB Inducing Kinase Attenuates Colorectal Cancer by Regulating Noncanonical NF-κB Mediated Colonic Epithelial Cell Regeneration.
  2. Inhibiting NF-kappaB inducing kinase improved the motor performance of ALS animal model.
    Title: Inhibiting NF-κB inducing kinase improved the motor performance of ALS animal model.
  3. High expression of NF-kappaB inducing kinase in the bulge region of hair follicle induces tumor.
    Title: High expression of NF-κB inducing kinase in the bulge region of hair follicle induces tumor.
  4. EDA2R-NIK signalling promotes muscle atrophy linked to cancer cachexia.
    Title: EDA2R-NIK signalling promotes muscle atrophy linked to cancer cachexia.
  5. NF-kappaB-inducing kinase maintains mitochondrial efficiency and systemic metabolic homeostasis.
    Title: NF-κB-inducing kinase maintains mitochondrial efficiency and systemic metabolic homeostasis.
  6. NIK/MAP3K14 in hepatocytes orchestrates NASH to hepatocellular carcinoma progression via JAK2/STAT5 inhibition.
    Title: NIK/MAP3K14 in hepatocytes orchestrates NASH to hepatocellular carcinoma progression via JAK2/STAT5 inhibition.
  7. Hepatic neddylation deficiency triggers fatal liver injury via inducing NF-kappaB-inducing kinase in mice.
    Title: Hepatic neddylation deficiency triggers fatal liver injury via inducing NF-κB-inducing kinase in mice.
  8. Biliary NIK promotes ductular reaction and liver injury and fibrosis in mice.
    Title: Biliary NIK promotes ductular reaction and liver injury and fibrosis in mice.
  9. Protection against autoimmunity is driven by thymic epithelial cell-mediated regulation of Treg development.
    Title: Protection against autoimmunity is driven by thymic epithelial cell-mediated regulation of T(reg) development.
  10. Constitutive activation of NF-kappaB inducing kinase (NIK) in the mesenchymal lineage using Osterix (Sp7)- or Fibroblast-specific protein 1 (S100a4)-Cre drives spontaneous soft tissue sarcoma.
    Title: Constitutive activation of NF-κB inducing kinase (NIK) in the mesenchymal lineage using Osterix (Sp7)- or Fibroblast-specific protein 1 (S100a4)-Cre drives spontaneous soft tissue sarcoma.
Submit: New GeneRIF Correction See all GeneRIFs (72)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (3) 
  • Spontaneous (1)  1 citation
  • Targeted (7)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables JUN kinase kinase kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in MAPK cascade IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to mechanical stimulus IEA
Inferred from Electronic Annotation
more info
  
involved_in defense response to virus IEA
Inferred from Electronic Annotation
more info
  
involved_in defense response to virus ISO
Inferred from Sequence Orthology
more info
  
involved_in immune response IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in non-canonical NF-kappaB signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in non-canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in fibrillar center IEA
Inferred from Electronic Annotation
more info
  
located_in fibrillar center ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
mitogen-activated protein kinase kinase kinase 14
Names
NF kappa B-inducing kinase
NF-kappa-beta-inducing kinase
Nfkb inducing kinase
alymphoplasia
serine/threonine-protein kinase NIK
NP_058592.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016896.3 → NP_058592.1  mitogen-activated protein kinase kinase kinase 14

    See identical proteins and their annotated locations for NP_058592.1

    Status: VALIDATED

    Source sequence(s)
    AK036200
    Consensus CDS
    CCDS25516.1
    UniProtKB/Swiss-Prot
    Q9WUL6
    UniProtKB/TrEMBL
    Q544K4
    Related
    ENSMUSP00000021324.3, ENSMUST00000021324.3
    Conserved Domains (2) summary
    smart00220
    Location:408 → 667
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd13991
    Location:395 → 662
    STKc_NIK; Catalytic domain of the Serine/Threonine kinase, NF-kappaB Inducing Kinase (NIK)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    103110590..103158227 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9WUL6.1 GenPept UniProtKB/Swiss-Prot:Q9WUL6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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