Map3k14 mitogen-activated protein kinase kinase kinase 14 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Map3k14provided by MGI
Official Full Name: mitogen-activated protein kinase kinase kinase 14provided by MGI
Primary source: MGI:MGI:1858204
See related: Ensembl:ENSMUSG00000020941 AllianceGenome:MGI:1858204
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Nik; aly
Summary: Enables NF-kappaB-inducing kinase activity. Involved in I-kappaB kinase/NF-kappaB signaling and immune response. Predicted to be located in cytosol; fibrillar center; and nucleoplasm. Is expressed in several structures, including alimentary system; cardiovascular system; nervous system; sensory organ; and skeleton. Used to study Sjogren's syndrome and primary biliary cholangitis. Orthologous to human MAP3K14 (mitogen-activated protein kinase kinase kinase 14). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in spleen adult (RPKM 11.8), thymus adult (RPKM 8.3) and 23 other tissues See more
Orthologs: human all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 11 E1; 11 66.8 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (103110590..103158227, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (103219764..103267401, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NIK/MAP3K14 in hepatocytes orchestrates NASH to hepatocellular carcinoma progression via JAK2/STAT5 inhibition.
Title: NIK/MAP3K14 in hepatocytes orchestrates NASH to hepatocellular carcinoma progression via JAK2/STAT5 inhibition.
Hepatic neddylation deficiency triggers fatal liver injury via inducing NF-kappaB-inducing kinase in mice.
Title: Hepatic neddylation deficiency triggers fatal liver injury via inducing NF-κB-inducing kinase in mice.
Biliary NIK promotes ductular reaction and liver injury and fibrosis in mice.
Title: Biliary NIK promotes ductular reaction and liver injury and fibrosis in mice.
Protection against autoimmunity is driven by thymic epithelial cell-mediated regulation of Treg development.
Title: Protection against autoimmunity is driven by thymic epithelial cell-mediated regulation of T(reg) development.
Constitutive activation of NF-kappaB inducing kinase (NIK) in the mesenchymal lineage using Osterix (Sp7)- or Fibroblast-specific protein 1 (S100a4)-Cre drives spontaneous soft tissue sarcoma.
Title: Constitutive activation of NF-κB inducing kinase (NIK) in the mesenchymal lineage using Osterix (Sp7)- or Fibroblast-specific protein 1 (S100a4)-Cre drives spontaneous soft tissue sarcoma.
NF-kappaB-inducing kinase maintains T cell metabolic fitness in antitumor immunity.
Title: NF-κB-inducing kinase maintains T cell metabolic fitness in antitumor immunity.
NIK links inflammation to hepatic steatosis by suppressing PPARalpha in alcoholic liver disease.
Title: NIK links inflammation to hepatic steatosis by suppressing PPARα in alcoholic liver disease.
Expression of Nik-related kinase in smooth muscle cells attenuates vascular inflammation and intimal hyperplasia.
Title: Expression of Nik-related kinase in smooth muscle cells attenuates vascular inflammation and intimal hyperplasia.
NF-kappaB-inducing kinase contributes to normal development of cortical thymic epithelial cells: its possible role in shaping a proper T-cell repertoire.
Title: NF-κB-inducing kinase contributes to normal development of cortical thymic epithelial cells: its possible role in shaping a proper T-cell repertoire.
SMAC mimetics promote NIK-dependent inhibition of CD4(+) TH17 cell differentiation.
Title: SMAC mimetics promote NIK-dependent inhibition of CD4(+) T(H)17 cell differentiation.

Submit: New GeneRIF Correction See all GeneRIFs (67)

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Spontaneous (1) 1 citation
Targeted (7) 1 citation
Chemically induced (ENU) (1)
Endonuclease-mediated (3)

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

Map3k14 (e-PCR), detects polymorphism
- UniSTS:507046

RH124391 (e-PCR)
- UniSTS:161213

NoName (e-PCR)
- UniSTS:489205

Homology

Homologs of the Map3k14 gene: The Map3k14 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 349 organisms have orthologs with human gene Map3k14
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables MAP kinase kinase kinase activity	IEA Inferred from Electronic Annotation more info
enables NF-kappaB-inducing kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	ISO Inferred from Sequence Orthology more info	PubMed
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in I-kappaB kinase/NF-kappaB signaling	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in I-kappaB kinase/NF-kappaB signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in defense response to virus	ISO Inferred from Sequence Orthology more info
involved_in immune response	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of I-kappaB kinase/NF-kappaB signaling	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in fibrillar center	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

Go to the top of the page Help

Preferred Names: mitogen-activated protein kinase kinase kinase 14

Names: NF kappa B-inducing kinase; NF-kappa-beta-inducing kinase; Nfkb inducing kinase; alymphoplasia; serine/threonine-protein kinase NIK

NP_058592.1

EC 2.7.11.25

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_016896.3 → NP_058592.1 mitogen-activated protein kinase kinase kinase 14

See identical proteins and their annotated locations for NP_058592.1

Status: VALIDATED

Source sequence(s)

AK036200

Consensus CDS

CCDS25516.1

UniProtKB/Swiss-Prot

Q9WUL6

UniProtKB/TrEMBL

Q544K4

Related

ENSMUSP00000021324.3, ENSMUST00000021324.3

Conserved Domains (2) summary

smart00220
Location:408 → 667

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd13991
Location:395 → 662

STKc_NIK; Catalytic domain of the Serine/Threonine kinase, NF-kappaB Inducing Kinase (NIK)