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CDHR5 cadherin related family member 5 [ Homo sapiens (human) ]

Gene ID: 53841, updated on 1-Jun-2020

Summary

Official Symbol
CDHR5provided by HGNC
Official Full Name
cadherin related family member 5provided by HGNC
Primary source
HGNC:HGNC:7521
See related
Ensembl:ENSG00000099834 MIM:606839
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MLPCDH; MUCDHL; MUPCDH; MU-PCDH
Summary
This gene is a novel mucin-like gene that is a member of the cadherin superfamily. While encoding nonpolymorphic tandem repeats rich in proline, serine and threonine similar to mucin proteins, the gene also contains sequence encoding calcium-binding motifs found in all cadherins. The role of the hybrid extracellular region and the specific function of this protein have not yet been determined. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jan 2010]
Expression
Biased expression in small intestine (RPKM 219.8), duodenum (RPKM 209.0) and 3 other tissues See more
Orthologs

Genomic context

See CDHR5 in Genome Data Viewer
Location:
11p15.5
Exon count:
16
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (616565..624967, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (616565..625067, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene PHD and ring finger domains 1 Neighboring gene interferon regulatory factor 7 Neighboring gene secretin Neighboring gene dopamine receptor D4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20219

Gene Ontology Provided by GOA

Function Evidence Code Pubs
beta-catenin binding IPI
Inferred from Physical Interaction
more info
PubMed 
calcium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 
cell adhesion molecule binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell adhesion ISS
Inferred from Sequence or Structural Similarity
more info
 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
homophilic cell adhesion via plasma membrane adhesion molecules IEA
Inferred from Electronic Annotation
more info
 
intermicrovillar adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of microvillus length IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
brush border membrane IDA
Inferred from Direct Assay
more info
PubMed 
clathrin-coated pit IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome HDA PubMed 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microvillus membrane IDA
Inferred from Direct Assay
more info
PubMed 
spanning component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
cadherin-related family member 5
Names
differentiation-associated catenin regulator
mu-protocadherin
mucin and cadherin-like protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001171968.2NP_001165439.2  cadherin-related family member 5 isoform 4 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 4), compared to isoform 1.
    Source sequence(s)
    AP006284
    Related
    ENSP00000351118.4, ENST00000358353.8
  2. NM_021924.5NP_068743.3  cadherin-related family member 5 isoform 1 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1, also known as MUCDHLFL).
    Source sequence(s)
    AA975851, AF301909, AK300991, AP006284, AY358368, DA373160
    Consensus CDS
    CCDS7707.1
    Related
    ENSP00000380676.2, ENST00000397542.7
  3. NM_031264.4NP_112554.3  cadherin-related family member 5 isoform 3 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.
    Source sequence(s)
    AP006284
    Consensus CDS
    CCDS7708.1
    Related
    ENSP00000345726.7, ENST00000349570.11

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    616565..624967 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011520190.2XP_011518492.1  cadherin-related family member 5 isoform X5

    Conserved Domains (1) summary
    cd11304
    Location:274343
    Cadherin_repeat; Cadherin tandem repeat domain
  2. XM_011520189.2XP_011518491.1  cadherin-related family member 5 isoform X3

    Conserved Domains (1) summary
    cd11304
    Location:274343
    Cadherin_repeat; Cadherin tandem repeat domain
  3. XM_011520188.2XP_011518490.1  cadherin-related family member 5 isoform X2

    Conserved Domains (2) summary
    cd11304
    Location:274343
    Cadherin_repeat; Cadherin tandem repeat domain
    pfam07001
    Location:452550
    BAT2_N; BAT2 N-terminus
  4. XM_006718253.3XP_006718316.1  cadherin-related family member 5 isoform X1

    Conserved Domains (2) summary
    cd11304
    Location:274343
    Cadherin_repeat; Cadherin tandem repeat domain
    pfam07001
    Location:452534
    BAT2_N; BAT2 N-terminus
  5. XM_011520191.2XP_011518493.1  cadherin-related family member 5 isoform X6

    Conserved Domains (1) summary
    cd11304
    Location:274343
    Cadherin_repeat; Cadherin tandem repeat domain
  6. XM_024448584.1XP_024304352.1  cadherin-related family member 5 isoform X4

    Conserved Domains (2) summary
    cd11304
    Location:274343
    Cadherin_repeat; Cadherin tandem repeat domain
    cl26464
    Location:452665
    Atrophin-1; Atrophin-1 family

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NT_187586.1 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    146464..154854 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_017717.3: Suppressed sequence

    Description
    NM_017717.3: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.
  2. NM_031265.1: Suppressed sequence

    Description
    NM_031265.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate, and there is an insufficient support for the transcript.
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