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IL20RB interleukin 20 receptor subunit beta [ Homo sapiens (human) ]

Gene ID: 53833, updated on 12-Oct-2019

Summary

Official Symbol
IL20RBprovided by HGNC
Official Full Name
interleukin 20 receptor subunit betaprovided by HGNC
Primary source
HGNC:HGNC:6004
See related
Ensembl:ENSG00000174564 MIM:605621
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DIRS1; FNDC6; IL-20R2
Summary
IL20RB and IL20RA (MIM 605620) form a heterodimeric receptor for interleukin-20 (IL20; MIM 605619) (Blumberg et al., 2001 [PubMed 11163236]).[supplied by OMIM, Feb 2009]
Expression
Biased expression in skin (RPKM 54.3) and esophagus (RPKM 20.8) See more
Orthologs

Genomic context

See IL20RB in Genome Data Viewer
Location:
3q22.3
Exon count:
9
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (136957983..137011085)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (136676707..136729927)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene solute carrier family 35 member G2 Neighboring gene NCK1 divergent transcript Neighboring gene RAD51AP1 pseudogene 1 Neighboring gene NCK adaptor protein 1 Neighboring gene IL20RB antisense RNA 1 Neighboring gene VISTA enhancer hs208 Neighboring gene VISTA enhancer hs209

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genetics of rheumatoid arthritis contributes to biology and drug discovery.
NHGRI GWA Catalog
Genome-wide association study of co-occurring anxiety in major depression.
NHGRI GWA Catalog
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
NHGRI GWA Catalog

Pathways from BioSystems

  • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
    Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
  • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Interleukin-19, 20, 22, 24, organism-specific biosystem (from REACTOME)
    Interleukin-19, 20, 22, 24, organism-specific biosystemThe interleukin-20 (IL20) subfamily comprises IL19, IL-20, IL-22, IL-24 and IL-26. They are members of the larger IL-10 family, but have been grouped together based on their usage of common receptor ...
  • Jak-STAT signaling pathway, organism-specific biosystem (from KEGG)
    Jak-STAT signaling pathway, organism-specific biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
  • Jak-STAT signaling pathway, conserved biosystem (from KEGG)
    Jak-STAT signaling pathway, conserved biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
  • Signaling by Interleukins, organism-specific biosystem (from REACTOME)
    Signaling by Interleukins, organism-specific biosystemInterleukins are low molecular weight proteins that bind to cell surface receptors and act in an autocrine and/or paracrine fashion. They were first identified as factors produced by leukocytes but a...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC34923

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cytokine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
interleukin-20 binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cytokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytokine-mediated signaling pathway TAS
Traceable Author Statement
more info
 
homeostasis of number of cells within a tissue IEA
Inferred from Electronic Annotation
more info
 
immune response-inhibiting signal transduction IEA
Inferred from Electronic Annotation
more info
 
inflammatory response to antigenic stimulus IEA
Inferred from Electronic Annotation
more info
 
negative regulation of T cell proliferation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of interferon-gamma production IEA
Inferred from Electronic Annotation
more info
 
negative regulation of interleukin-2 production IEA
Inferred from Electronic Annotation
more info
 
negative regulation of type IV hypersensitivity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of interleukin-10 production IEA
Inferred from Electronic Annotation
more info
 
positive regulation of interleukin-4 production IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
interleukin-20 receptor subunit beta
Names
IL-20 receptor subunit beta
IL-20R-beta
IL-20RB
fibronectin type III domain containing 6
interleukin 20 receptor beta subunit
interleukin-20 receptor II

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_144717.4NP_653318.2  interleukin-20 receptor subunit beta precursor

    See identical proteins and their annotated locations for NP_653318.2

    Status: VALIDATED

    Source sequence(s)
    AY358305, BC063696
    Consensus CDS
    CCDS3093.1
    UniProtKB/Swiss-Prot
    Q6UXL0
    Related
    ENSP00000328133.4, ENST00000329582.9
    Conserved Domains (2) summary
    pfam01108
    Location:30124
    Tissue_fac; Tissue factor
    cl21522
    Location:136225
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    136957983..137011085
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011512910.3XP_011511212.1  interleukin-20 receptor subunit beta isoform X1

    Conserved Domains (2) summary
    pfam01108
    Location:35129
    Tissue_fac; Tissue factor
    cl21522
    Location:141230
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  2. XM_011512911.2XP_011511213.1  interleukin-20 receptor subunit beta isoform X2

    See identical proteins and their annotated locations for XP_011511213.1

    Conserved Domains (2) summary
    pfam01108
    Location:177
    Tissue_fac; Tissue factor
    cl21522
    Location:89178
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  3. XM_017006632.1XP_016862121.1  interleukin-20 receptor subunit beta isoform X2

    Conserved Domains (2) summary
    pfam01108
    Location:177
    Tissue_fac; Tissue factor
    cl21522
    Location:89178
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  4. XM_006713665.4XP_006713728.1  interleukin-20 receptor subunit beta isoform X2

    See identical proteins and their annotated locations for XP_006713728.1

    Conserved Domains (2) summary
    pfam01108
    Location:177
    Tissue_fac; Tissue factor
    cl21522
    Location:89178
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
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